A5054794894- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Blood Pressure and Hypertension Studies
- CNS Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Respiratory Support and Mechanisms
- Pharmacology and Obesity Treatment
- Eosinophilic Esophagitis
- Diabetes and associated disorders
- Hematopoietic Stem Cell Transplantation
- Calcium Carbonate Crystallization and Inhibition
- Infectious Diseases and Tuberculosis
- Potassium and Related Disorders
- Metabolism and Genetic Disorders
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Renal and related cancers
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Viral-associated cancers and disorders
Santobono Children's Hospital
2013-2024
University of Naples Federico II
2013-2020
University of Salerno
2017
Boston Children's Hospital
2014
Hôpital Sainte-Marguerite
1989-1990
Inserm
1989
Laboratoire de Chimie
1989
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the of a poor outcome. DKD is associated very high cardiovascular risk, which requires simultaneous treatment these by implementing an intensified multifactorial approach. However, efficacy intervention on major fatal/non-fatal events (MACEs) has been poorly investigated.
Five-year event-free survival in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) currently exceeds 80–85%. However, 15–20% of patients still experience a relapsed/refractory disease. From 1 January 2015 to 31 December 2020, thirty-nine patients, 0–21 years old with r/r BCP-ALL were treated blinatumomab the aim inducing remission (n = 13) or reducing MRD levels 26) frame different multiagent chemotherapy schedules, seven AIEOP centers. Patients compassionate and/or off-label...
Women with type 2 diabetes experience higher cardiovascular and mortality risk than men possibly because of a sub-optimal cardio-protective treatment. We evaluated whether an intensive multifactorial therapy (MT) produces similar protective effect on development adverse outcomes in women men. Nephropathy Diabetes study is open-label cluster randomized trial comparing the Usual Care (UC) or MT main factors (blood pressure < 130/80 mmHg, HbA1c 7%, LDL 100 mg/dL, total cholesterol 175 mg/dL)...
Acute leukemia is the most common pediatric cancer. In cases, this disease results from malignant transformation of either B-cell (B-ALL) or, less frequently, T-cell progenitors (T-ALL). Recently, a marked overexpression KCTD15, member emerging class potassium (K) channel tetramerization domain-containing proteins (KCTDs) has been detected in both patients and continuous cell lines as vitro model systems. Because there growing evidence key, yet diversified, roles played by KCTDs cancers, we...
Although children and young adults with Hodgkin's lymphoma usually have a favorable prognosis, patients primary refractory disease some subsets of relapsed still dismal outcome. Brentuximab vedotin (BV) in combination bendamustine may represent suitable salvage therapy; data on 32 aged less than 25 years were retrospectively analyzed. Patients received up to six cycles treatment BV 1.8 mg/kg day 1 90-120 mg/m2 days 2 3. At the end treatment, overall response rate was 81%. The 3-year...
Long non-coding RNAs are longer than 200 bps that do not encode any proteins and able to alter gene expression by acting on different steps of regulation, including DNA methylation chromatin structure. They represent a class biomarkers crescent interest in the hematologic oncologic fields. Recent studies showed levels specific lncRNAs correlate with prognosis paediatric patients Acute Lymphoblastic Leukaemia.We used NGS approaches analyse transcriptome 9 childhood B-ALL 6 T-ALL patients,...
The toxicity and efficacy of intrathecal liposomal cytarabine (LC) were evaluated in children with central nervous system (CNS) relapsed/refractory acute leukemia/lymphoma. Thirty patients (male:female ratio 21:9; median age 9.4 years) CNS relapsed/resistant disease treated LC at dosages adjusted for age. Twenty-seven (90%) simultaneously received systemic chemotherapy, including concurrent high-dose or methotrexate 21 (70%) cases. Of 28 evaluable response, 25 (89%) achieved complete...
We reported two cases of acute recurrent pancreatitis lasting for 8 and 10 years, respectively, characterized by abdominal pain associated with an increased serum level pancreatic enzymes in one case transient enlargement the pancreas on sonography CT scan. Exocrine endocrine function remained normal. Pain attacks were headache or typical migraine, myalgia, pruritus, diarrhea. In only, IgE was increased. both cases, symptoms reproduced 2 h following consumption some particular food cured...
Background Paediatric acute B-cell lymphoblastic leukaemia is the most common cancer of paediatric age. Although advancement scientific and technological knowledge has ensured a huge step forward in management this disease, there are 15%–20% cases recurrence leading to serious complications for patient sometimes even death. It therefore necessary identify new increasingly personalised biomarkers capable predicting degree risk B-ALL order allow correct patients. Methods Starting from our...
Letter to the EditorCoronavirus disease COVID-19 has deeply modified national health services with a profound impact on hospital and in particular emergency intensive care units (ICU) activities. As recently reported Italy pediatric accesses substantially decreased likely due instructions prevent overcrowding rooms spread of SARS-CoV-2 infection fear infection.1 At Santobono-Pausilipon Hospital (Neaples), March 2020 were only one fifth those registered 2019 same period. Likewhise marked...
Reduced bone mineral density (BMD) is a well-known complication in childhood acute lymphoblastic leukemia (ALL) survivors; the optimal method to assess BMD still debated. We studied by quantitative ultrasound (QUS) 72 ALL survivors, and evaluated any correlation with cumulative doses of steroids cytotoxic agents. Mean age at diagnosis was 61±45 months, while mean QUS 318.3±129.6 months; period follow-up 41.2±37.8 months. amplitude-dependent speed sound z-score -1.22±1.19. Ten survivors...