A5054450175- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Complement system in diseases
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Protein Tyrosine Phosphatases
- Galectins and Cancer Biology
- Neutropenia and Cancer Infections
- Virus-based gene therapy research
- Blood disorders and treatments
- Cytomegalovirus and herpesvirus research
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Polyomavirus and related diseases
- Tracheal and airway disorders
- Blood groups and transfusion
Azienda USL di Pescara
2024
ASL Roma
2023
CTO Hospital
2021-2022
Ospedale Regina Margherita
1994-2021
Piedmont Reference Center for Epidemiology and Cancer Prevention
2019
University of Turin
1998-2014
Boston Children's Hospital
2013
Ospedale Policlinico San Martino
1992
Medizinische Hochschule Hannover
1992
The restrictive measures adopted worldwide against SARS-CoV-2 produced a drastic reduction in respiratory pathogens, including RSV, but dramatic rebound was thereafter reported. In this multicenter retrospective observational study 15 Pediatric Emergency Departments, all children <3 years old with RSV infection admitted between 1 September and 31 December 2021 were included compared to those the same period of 2020 2019. primary aim evaluate epidemiology during after COVID-19 pandemic...
The SARS-CoV2 Pandemic affected the global epidemiology of respiratory infections, including Respiratory Syncytial Virus (RSV), thanks to state governments’ implementation mitigation strategies, like promotion face masks and lockdowns. However, after Pandemic, dramatic resurge these diseases was reported worldwide. Our retrospective study, involving three Spoke Pediatric Departments, includes all infants under one year age hospitalized for RSV bronchiolitis in a period before (2017-2020),...
Genetic screening for severe congenital immuno-hematological diseases offers potential early intervention, particularly through preemptive allogeneic stem cell transplantation (HSCT). However, the clinical value of such depends on precise prognostic predictions based genotype-phenotype correlations and/or functional confirmation. We investigated familial hemophagocytic lymphohistiocytosis type 2 (FHL2), caused by PRF1 variants. Specifically we evaluated significance frequent A91V variant, if...
Abstract Neuroblastoma (NB) and Ewing’s sarcoma (ES) represent the most common extracranial solid tumors of childhood. Heat shock proteins (HSP) are elevated in cancer cells their over‐expression was correlated to drug‐resistance. In this work we identified HSP by a sensitive proteomic analysis NB ES cell lines, then, studied response doxorubicin. Some were constitutively more expressed than cells. Doxorubicin‐stimulated only Quercetin found inhibit expression depleting heat factor 1 (HSF1)...
Sepsis related coagulopathy ranges from mild laboratory alterations up to severe disseminated intravascular coagulation (DIC). There is evidence that DIC involved in the pathogenesis of microvascular dysfunction contributing organ failure. Additionally, systemic activation coagulation, by consuming platelets and factors, may cause bleeding. Thrombin generation via tissue factor/factor VIIa route, contemporary depression antithrombin protein C anticoagulant system, as well impaired fibrin...
A multicentre study evaluating the presence of glycosil phosphatidyl-inositol (GPI)-negative populations was performed in 85 children with acquired aplastic anemia (AA). GPI-negative population observed 41% patients at diagnosis, 48% during immune-suppressive therapy (IST), and 45% off-therapy. No association found between a diagnosis response to IST. In addition, rate IST did not differ who were GPI-positive later developed 11 remained GPI-positive. Two >10%, laboratory signs hemolysis...
The diagnosis of Riga-Fede disease was eventually made in a 15-month-old child presenting with persisting deep ulcer on the tip his tongue.
Bronchiolitis is an acute viral infection of the lower respiratory tract that affects infants and young children. Respiratory syncytial virus (RSV) most common causative agent; however, other viruses can be involved in this disease. We retrospectively reviewed clinical features aged less than 12 months hospitalized for bronchiolitis our Pediatric Units Chivasso, Cirié, Ivrea Piedmont, Northern Italy, over two consecutive seasons (September 2021–March 2022 September 2022–March 2023)....
Diamond-Blackfan anaemia (DBA) is a congenital disease characterized by defective erythroid progenitor maturation: 30% of patients have malformations. The link between these malformations and erythropoiesis unclear: defect in molecule acting both on embryo development haemopoiesis has been proposed. Inheritance autosomal dominant most familial cases, but recessive families also reported. Many cases are sporadic. A DBA locus mapped chromosome 19q13.2 (Gustavsson et al, 1997), several unlinked...
Neuroblastoma (NB) is a common malignant solid tumor in children and accounts for 15% of childhood cancer mortality. Amplification the N-Myc oncogene well-established poor prognostic marker NB patients strongly correlates with higher aggression resistance to treatment. New therapies N-Myc-amplified need be developed. After treating cells BSAO/SPM, detection apoptosis was determined after annexin V-FITC labeling DNA staining propidium iodide. The mitochondrial membrane potential activity...
Self-renewal, proliferation, differentiation, homing, and mobilization of hematopoietic progenitor cells (HPCs) are regulated by a complex mechanism that involves the bone marrow (BM) microenvironment. Cell adhesion molecules (CAMs) expressed on HPCs endothelial stromal play pivotal role in this process. In study, we have used three-color cytofluorometric analysis to compare CAM expression subsets cord blood (CB) BM examined effect short exposure various cytokines L-selectin expression. The...
A high number of stem cells migrate in fetal blood and, at birth, the progenitors cord equals or exceeds that adult bone marrow. Recently hemopoiesis has been successfully reconstituted with infusion cells. It is important to clearly define quantity and quality totipotent multilineage evaluate possibility their utilization transplants. Our first aim was study growth characteristics progenitors. We have evaluated cycling thymidine suicide technique production, by phytohemagglutinin (PHA)...
Noonan syndrome (NS) is among the most common nonchromosomal disorders affecting development and growth. NS genetically heterogeneous, being caused by germline mutations various genes implicated in RAS signaling network. This network transduces extracellular signals into intracellular biochemical transcriptional responses controlling cell proliferation, differentiation, metabolism, senescence. To explore consequences of NS-causing mutations, we performed global mRNA expression profiling on...