A5045920468- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Transplantation: Methods and Outcomes
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Polyomavirus and related diseases
- Antibiotic Use and Resistance
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Infectious Diseases and Mycology
- Infective Endocarditis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Viral Infections and Immunology Research
- Actinomycetales infections and treatment
- Bacterial Infections and Vaccines
- Toxoplasma gondii Research Studies
- Nosocomial Infections in ICU
- Respiratory and Cough-Related Research
- Tuberculosis Research and Epidemiology
- Influenza Virus Research Studies
- Fungal Infections and Studies
- Infections and bacterial resistance
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2016-2025
University of Turin
2009-2025
Piedmont Reference Center for Epidemiology and Cancer Prevention
2024
Fondazione Ricerca Molinette
2021-2024
Azienda Ospedaliero Universitaria San Giovanni Battista
2010-2013
The restrictive measures adopted worldwide against SARS-CoV-2 produced a drastic reduction in respiratory pathogens, including RSV, but dramatic rebound was thereafter reported. In this multicenter retrospective observational study 15 Pediatric Emergency Departments, all children <3 years old with RSV infection admitted between 1 September and 31 December 2021 were included compared to those the same period of 2020 2019. primary aim evaluate epidemiology during after COVID-19 pandemic...
Here we report on seven intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) who developed positive rectal swabs and invasive infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp). Notwithstanding the infection prevention measures introduced during COVID-19 pandemic changes in hospitalised population, attention CP-Kp must remain high, especially critically ill setting.
Abstract Objectives The measurement of VOCs release in the headspace a bacterial culture represents new approach to rapidly assess antimicrobial susceptibility. Herein, we evaluated diagnostic performance VITEK® REVEAL™ system directly from collection Gram-negative positive blood cultures. Materials and methods One hundred twenty-eight cultures were included analysis (Enterobacterales, n = 95; Pseudomonas aeruginosa, 21; Acinetobacter baumannii complex, 12). Samples processed using according...
Carbapenem-Resistant Gram-Negative Bacteria, including Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA), are common causes of infections in intensive care units (ICUs) Italy. This prospective observational study evaluated the epidemiology, management, microbiological characterization, outcomes hospital-acquired CRE or CRPA treated selected ICUs The included patients with due to 20 from June 2021 February 2023. primary endpoint was 1-year incidence CRE/CRPA infections. Secondary...
Background and Objectives: Stenotrophomonas maltophilia is a ubiquitous, aerobic, Gram-negative bacillus causing increasing concern in patients affected by haematological malignancies. Materials Methods: We report case series from two centres Northern Italy to describe the characteristics, outcome microbiological response of S. infections with malignancies and/or allogenic hematopoietic stem cell transplantation (aHSCT). Results: Ten were included. The median age was 67 years, seven (70%)...
Background: Bacterial superinfections are common complications during viral infections, but the impact of multidrug-resistant (MDR) pathogens in critically ill patients affected by coronavirus disease 2019 (COVID-19) is still debated. Methods: This an observational, monocentric, and prospective study designed to investigate incidence, risk factors, outcomes MDR bacterial COVID-19 admitted intensive care unit (ICU). Results: A high incidence (66%, 159/241) was observed: ventilator-associated...
Background: Lung transplantation is a life-saving option for patients with end-stage respiratory diseases, but risk of infections remains critical ensuring long-term organ function. This study aimed to assess immune recovery in lung transplant recipients by measuring IFN-γ levels using the QuantiFERON Monitor Test (QFM). Results were correlated episodes infection and rejection explore assay’s predictive potential. Methods: A retrospective was conducted on 15 at Transplant Centre Turin (Città...
Respiratory infections, particularly of the upper airways, play an important role in human pathologies, with them being most common cause disease both children and adults, a relevant impact on healthcare systems. Pathogen identification is critical patients, molecular assays used methods. Herein, epidemiology respiratory viruses Northwestern Italy was studied by using tract syndromic panel over period eight years, from January 2016 to December 2023, order evaluate COVID-19 pandemic this...
Nontuberculous mycobacteria (NTM) identification is essential for establishing the relevance of isolate and appropriate antimicrobial therapy. Traditionally, NTM performed by using Line Probe Assays (LPA), a costly time-consuming technique requiring trained personnel. MALDI-TOF MS promising tool identification, its use rapidly growing. We evaluated newly introduced MBT Mycobacteria kit (MBT) MycoEx preparation protocol (Bruker Daltonics, Germany) LPA results as reference. Fifty grown on 7H11...
Recently Candida auris has emerged as a multi-resistant fungal pathogen, with significant clinical impact, and become critical issue in WHO priority list, due to its unique ability persist for long time on human skin hospital environments. It is therefore fundamental reinforce surveillance protocols limit nosocomial outbreaks. The study purpose was the Fourier-Transform Infrared Spectroscopy (FT-IR) application investigate phylogenetic relationships between isolated strains within C....
Considering the growing prevalence of carbapenem-resistant Gram-negative bacteria (CR-GNB) bloodstream infection (BSI) in intensive care units (ICUs), identification specific risk factors and development a predictive model allowing for early patients at CR-Klebsiella pneumoniae, Acinetobacter baumannii or Pseudomonas aeruginosa are essential. In this retrospective case-control study including all consecutive showing an episode BSI ICUs university hospital Italy period January-December 2016,...
Abstract Background The COVID-19 pandemic has increased the incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, a comparison VAP in and non-COVID-19 cohorts, particularly context with high prevalence multidrug-resistant (MDR) organisms, is lacking. Material Methods We conducted single-center, mixed prospective retrospective cohort study comparing patients admitted to intensive care unit (ICU) “Città della Salute e Scienza” University Hospital Turin,...
Acinetobacter baumannii (A. baumannii) nosocomial infections represent a serious hazard to public health, given high mortality rates and rapid spread of multidrug-resistance. The primary outcome this study was evaluate predictors 14- 30-d in bloodstream (BSIs) due both carbapenem-resistant carbapenem-sensitive Acinetobacter. Secondary end points were identify risk factors for BSIs A. (CRAB) develop predictive model CRAB-related BSIs.
Recently, a large number of nosocomial infections have been caused by an emerging pathogen that is rising as worldwide issue in human health:
Abstract Blot and colleagues have proposed putative invasive pulmonary aspergillosis (PIPA) definitions for troublesome diagnosis in suspected patients outside the classical criteria of immunosuppression. We retrospectively included study all admitted with an Aspergillus spp. positive culture within lower airway samples. Overall, positivity respiratory samples was 0.97 every 1000 hospital admissions (HA): 4.94 0.28/1000/HA, respectively, intensive care units (ICUs) medical wards (MW). 66.6%...