A5064698415- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Use and Resistance
- Fungal Infections and Studies
- Tuberculosis Research and Epidemiology
- Pharmaceutical and Antibiotic Environmental Impacts
- Cervical Cancer and HPV Research
- Gallbladder and Bile Duct Disorders
- Enterobacteriaceae and Cronobacter Research
- Antibiotics Pharmacokinetics and Efficacy
- Fermentation and Sensory Analysis
- Pancreatic and Hepatic Oncology Research
- Infective Endocarditis Diagnosis and Management
- Horticultural and Viticultural Research
- Legionella and Acanthamoeba research
- Urinary Tract Infections Management
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Eosinophilic Esophagitis
- Infectious Diseases and Mycology
University of Palermo
2016-2025
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2018-2023
Children's Hospital of Eastern Ontario
2023
University of Ottawa
2023
Central Research Institute of Epidemiology
2022
University of Naples Federico II
2020
University of Palermo
2020
University of Campania "Luigi Vanvitelli"
2020
University of Alberta
2020
Helicobacter pylori and Epstein-Barr virus (EBV) infection have recently been shown to be associated with gastric diseases. Polymorphisms in genes encoding cytokines such as interleukin 10 (IL-10) 1 Receptor (IL-1RN) influence cytokine secretion levels appear contribute the risk of developing gastroduodenal To our knowledge, this is first preliminary study address association coinfection H. EBV their correlation genetic predisposition development diseases.Gastric biopsy samples 96 patients...
Multidrug resistance among bacterial pathogens is an ongoing global problem and renders antimicrobial agents ineffective at treating infections. In the health care setting, infections caused by multidrug-resistant (MDR) Gram-negative bacteria can cause increased mortality, longer hospital stays, higher treatments costs. The aim of Tigecycline Evaluation Surveillance Trial (TEST) to assess in vitro activities tigecycline other contemporary against clinically relevant pathogens. This paper...
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Background In Italy, Klebsiella pneumoniae carbapenemase producing K. (KPC-Kp) strains are highly endemic and KPC CC258 is reported as the widely predominating clone. Palermo, previous reports have confirmed this pattern. However, recent preliminary findings suggest that an epidemiological change likely ongoing towards a polyclonal KPC-Kp spread. Here we present results of molecular typing 94 carbapenem non susceptible isolates detected during 2014 in three different hospitals Italy. Methods...
Endemic presence of Klebsiella pneumoniae resistant to carbapenem in Italy has been due principally the clonal expansion CC258 isolates; however, recent studies suggest an ongoing epidemiological change this geographical area.50 K. strains, 25 carbapenem-resistant (CR-Kp) and susceptible (CS-Kp), collected from march 2014 2016 at Laboratory Bacteriology Paolo Giaccone Polyclinic University hospital Palermo, Italy, were characterized for antibiotic susceptibility fully sequenced by next...
The ESCPM group (Enterobacter species including Klebsiella aerogenes - formerly Enterobacter aerogenes, Serratia species, Citrobacter freundii complex, Providencia and Morganella morganii) has not yet been incorporated into systematic surveillance programs. We conducted a multicentre retrospective observational study analysing all strains isolated from blood cultures in 27 European hospitals over 3-year period (2020-2022). Diagnostic approach, epidemiology, antimicrobial susceptibility were...
Background:Candida auris has emerged globally as a multi-drug resistant yeast and is commonly associated with nosocomial outbreaks in ICUs. Methods: We conducted retrospective observational multicentre study to determine the epidemiology of C. infections, its management strategies, patient outcomes, infection prevention control practices across 10 centres from five countries. Results: Significant risk factors for include age group 61-70 years (39%), recent history ICU admission (63%),...
Surgical site infections (SSIs) after cardiac surgery increase morbidity and mortality rates. This multicenter study aimed to identify risk factors associated with SSIs heart surgery. Conducted from January March 2023, this prospective included 167 patients aged >16 years post-heart SSIs. The primary focus was the 30-day mortality. Univariate analysis multivariate logistic regression utilizing backward elimination method were used establish final model. Several significantly correlated These...
Carbapenem-Resistant Gram-Negative Bacteria, including Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA), are common causes of infections in intensive care units (ICUs) Italy. This prospective observational study evaluated the epidemiology, management, microbiological characterization, outcomes hospital-acquired CRE or CRPA treated selected ICUs The included patients with due to 20 from June 2021 February 2023. primary endpoint was 1-year incidence CRE/CRPA infections. Secondary...
Background/Objectives: HPV is the most common sexually transmitted infectious agent worldwide and adolescents are at high risk of contracting HPV. The aim our study was to find out how much know about virus its effects, obtain information on attitudes behaviors regarding vaccination close these gaps. Methods: As part ESPRIT project, 598 lower secondary (11–14 years) upper (14–19 school students from three Italian regions were surveyed between December 2023 March 2024 using a seven-question...
Background: Bilio-pancreatic tumors are a severe form of cancer with high rate associated mortality. These patients showed the presence bacteria such as Escherichia coli and Pseudomonas spp. in bile-pancreatic tract. Therefore, efficient antibiotic therapy is essential to reduce bacterial resistance adverse events patients. Recent studies on seasonality infectious diseases may aid developing effective preventive measures. This study examines seasonal impact bile microbiota composition its...
Abstract Background Pseudomonas aeruginosa bloodstream infections (Pa-BSIs) are still a major cause of mortality in ICUs, posing many treatment uncertainties. Methods This multicentre, retrospective study analysed data from 14 Italian hospitals, including all consecutive adults developing Pa-BSI ICU during 2021–22 and treated with antibiotics for at least 48 h. The primary aim was to identify predictors 30 day using Cox regression. Results were adjusted inverse probability weighting (IPTW)...
Listeria monocytogenes is an important foodborne pathogen, markedly persistent even in harsh environments and responsible for high hospitalization mortality rates. The aim of the present study was to detect strains circulating Sicily over a five-year period characterize their antimicrobial resistance profiles. key element this sharing data among various entities involved food control clinical surveillance listeriosis order develop integrated approach pathogen. A total 128 isolates were...
The resistance of Helicobacter pylori strains to clarithromycin is increasing in several developed countries and their association with a genetic pattern circulation has been variously explained as related different geographical areas. In this study we have reported: the prevalence H. pylori, isolated Sicily, clarithromycin; principal point mutation associated resistance; more frequent between cagA, EPIYA motif, vacA oipA genes. Resistance was detected 25% cases, main involved being A2143G....
While bivalent and quadrivalent HPV vaccines have been used for about 10 years, a nonavalent vaccine against types 6/11/16/18/31/33/45/52 58 has recently approved by FDA EMA is now commercially available. The objective of our study was to evaluate the potential impact on infection related low- high-grade squamous intraepithelial lesions (LSIL, HSIL), compared vaccine, in female population living Sicily (Italy). Low estimates were calculated as prevalence genotypes, alone or association, but...
Background Among multidrug-resistant (MDR) bacteria able to threaten human health, carbapenem-resistant Enterobacterales (CRE) have become a major public health threat globally. National and international guidelines point out the importance of active routine surveillance policies prevent CRE transmission. Therefore, defining lines intervention strategies capable containing controlling spread is considered determinant. screening one main actions curb transmission control outbreaks, outlining...
Background: The gut microbiota play an essential role in protecting the host against pathogenic microorganisms by modulating immunity and regulating metabolic processes.In response to environmental factors, microbes can hugely alter their metabolism.These factors substantially impact have potential pathologic implications.Particularly colonizing pancreas biliary tract tissues may be involved chronic inflammation cancer evolution.Purpose: To evaluate effect of bile on survival patients with...