A5090902756- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Immunotherapy and Immune Responses
- Bacterial Identification and Susceptibility Testing
- Immune Cell Function and Interaction
- Fungal Infections and Studies
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Nail Diseases and Treatments
- Reproductive tract infections research
- Immune responses and vaccinations
- Antifungal resistance and susceptibility
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- COVID-19 and healthcare impacts
- Disaster Response and Management
- Complementary and Alternative Medicine Studies
- Mosquito-borne diseases and control
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- HIV/AIDS drug development and treatment
- Cystic Fibrosis Research Advances
Ministero della Salute
2020-2024
Istituto Superiore di Sanità
2011-2024
University of Pisa
2022-2023
European Centre for Disease Prevention and Control
2016-2019
Istituto Zooprofilattico Sperimentale delle Venezie
2018
Sapienza University of Rome
2000
University of Padua
1983
We report a study on vector competence of an Italian population Aedes albopictus for Zika virus (ZIKV). Ae. was susceptible to ZIKV infection (infection rate: 10%), and the could disseminate secreted in mosquito's saliva (dissemination 29%; transmission 29%) after extrinsic incubation period 11 days. The observed lower than that aegypti colony tested parallel.
Antimicrobial resistance (AMR) poses serious challenges to the healthcare systems worldwide. Multiple factors and activities contribute development spread of antimicrobial-resistant microorganisms. Monitoring progress in combating AMR is fundamental at both global national levels drive multisectoral actions, identify priorities, coordinate strategies. Since 2017, World Health Organization (WHO) has collected data through Tracking Country Self-Assessment Survey (TrACSS). TrACSS are published...
Early detection, standardized therapy, adequate infrastructure and strategies for quality improvement should constitute essential components of every hospital's sepsis plan. To investigate the extent to which recommendations from guidelines are implemented availability care patients with in acute hospitals. A multidisciplinary cross-sectional questionnaire was used This included use definitions, implementation guideline recommendations, diagnostic therapeutic infrastructure, antibiotic...
Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, national surveillance bloodstream (BSI) CPE (Klebsiella pneumoniae and Escherichia coli) was instituted 2013. All CPE-BSI cases reported years 2014-17 were analysed order investigate incidence rate (IR), trend, main individual characteristics enzymes involved resistance. Throughout this period, 7,632 (IR: 3.14/100,000 inhabitants) from all 21 regions autonomous provinces with an...
The COVID-19 pandemic has affected national healthcare systems worldwide, with around 282 million cumulative confirmed cases reported in over 220 countries and territories as of the end 2021. Italian National Health System was heavily affected, detrimental impacts on preventive service delivery. Routine vaccination services were disrupted across country during first months pandemic, both access to demand for vaccines have decreased pandemic. In many cases, parents preferred postpone...
Candida auris is an emerging fungus that represents a serious health threat globally. In Italy, the first case was detected in July 2019. Then, one reported to Ministry of Health (MoH) on January 2020. Nine months later, huge number cases were northern Italy. Overall, 361 17 healthcare facilities between 2019 and December 2022 Liguria, Piedmont, Emilia-Romagna, Veneto regions, including 146 (40.4%) deaths. The majority (91.8%) considered as colonised. Only had history travel abroad....
We investigated the susceptibility of an Italian population Culex pipiens mosquitoes to Zika virus (ZIKV) infection, tested in parallel with Aedes aegypti, as a positive control. analysed at 0, 3, 7, 10, 14, 20 and 24 days after infectious blood meal. Viral RNA was detected body Cx. up three post-infection, but not later time points. Our results indicate that is susceptible ZIKV infection.
Blood culture (BC) is still the standard for diagnosing bloodstream infections (BSIs), especially those caused by bacteria and fungi. Infection-complicating sepsis or septic shock often occurs at BSI onset, making necessary to improve diagnostic yield of positive BCs. Among BC systems currently available, BACT/ALERT® VIRTUO® (VIRTUO) system has been developed shorten time detection (TTD) In this study, we assessed TTD 330 clinically relevant species including 14 Gram-positive, Gram-negative,...
Abstract Background Identifying healthcare workers (HCW) who have less awareness and knowledge on antibiotic use resistance represents a challenge for public health, since it might help the development of novel educational training initiatives tailored specific subgroups professionals. This work aims to compare knowledge, attitudes behaviors across different groups Italian HCW. Methods We used data from multi-country multi-professional survey launched by European Centre Disease Prevention...
Trichophyton indotineae is an emerging dermatophyte species that plays a relevant role in human healthcare. It has been associated with severe chronic skin infections and high level of terbinafine resistance. T. endemic to India, Iran, Iraq but several cases have reported Europe, recently. In this manuscript, the authors report first clinical description tinea corporis onychomycosis due indotineae. The patient was 42-year-old female from India lived Umbria (Central Italy) for last two years....
The phenomenon of antimicrobial resistance (AMR) is a critical global health challenge, with prospects indicating its potential to become the leading cause death worldwide in coming years. Individuals pre-existing conditions, such as neoplastic disease undergoing chemotherapy, those on immunosuppressive therapy, and individuals rare diseases like cystic fibrosis (CF), face heightened challenges due AMR. CF caused by deficiency synthesis Cystic Fibrosis Transmembrane Conductance Regulator...
Purpose. From May 2015 to March 2016, an outbreak due Listeria monocytogenes serotype 1/2a and clinical pulsotype never previously isolated in Europe occurred central Italy, involving 24 confirmed cases. The article provides a description of the investigation carried out by multidisciplinary network. Methodology. Epidemiological microbiological surveillance was conducted confirm detect food vehicle infection. origin destination implicated its ingredients were investigated tracing-back...
An infodemic represents a concern for public health, influencing the general population's perceptions of key health issues. Misinformation is rapidly spread by social media, particularly among young generations. We used data from WHO "Social Media and COVID-19" study, which was conducted in 24 countries worldwide on over 23,000 subjects aged 18-40 years, to explore Generation Z Millennials' models health-information-seeking behaviors media. summarized most sources information, content...
Background Among multidrug-resistant (MDR) bacteria able to threaten human health, carbapenem-resistant Enterobacterales (CRE) have become a major public health threat globally. National and international guidelines point out the importance of active routine surveillance policies prevent CRE transmission. Therefore, defining lines intervention strategies capable containing controlling spread is considered determinant. screening one main actions curb transmission control outbreaks, outlining...
Macrophages are key targets of HIV-1 infection. We have previously described that the expression CC chemokine ligand 2 (CCL2) increases during monocyte differentiation to macrophages and it is further up-modulated by exposure. Moreover, CCL2 acts as an autocrine factor promotes viral replication in infected macrophages. In this study, we dissected molecular mechanisms which neutralization inhibits monocyte-derived (MDM), potential involvement innate restriction factors protein sterile alpha...
We determined immune cross-recognition and the degree of Tat conservation in patients infected by local human immunodeficiency virus (HIV) type 1 strains. The data indicated a similar prevalence total epitope-specific anti-Tat IgG 578 serum samples from HIV-infected Italian (n=302), Ugandan (n=139), South African (n=137) subjects, using same B clade protein that is being used vaccine trials. In particular, antibodies were detected 13.2%, 10.8%, 13.9% HIV-1-infected individuals Italy, Uganda,...
HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated indinavir followed for clinical evolution, drug pharmacokinetics biomarkers. A favorable course was associated high plasma levels, reduced production of basic fibroblast growth factor, lower numbers circulating endothelial cells, a decrease in antibody titers against...
Maintaining high vaccine coverage (VC) for pediatric vaccinations is crucial to ensure herd immunity, reducing the risk of vaccine-preventable diseases (VPD). The Italian vaccination Law (n. 119/2017) reinforced mandates polio, diphtheria, tetanus, and hepatitis B, extending mandate pertussis, Haemophilus influenzae type b, chickenpox, measles, mumps, rubella, children up 16 years age. We analyzed national temporal trends childhood immunization rates from 2014 2019 evaluate impact mandatory...
From 2013 onwards, a large outbreak of Mycobacterium chimaera (MC) invasive infection, which was correlated with the use contaminated heater-cooler units (HCUs) during open chest surgery, reported from all over world. Here, we report results epidemiological and molecular investigations conducted in Italy after alarm raised about this epidemic event.MC strains isolated patients or HCU devices were characterized by genomic sequencing analysis.Through retrospective analysis between January 2010...