A5043131027- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Health, Environment, Cognitive Aging
- BRCA gene mutations in cancer
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Antibiotic Use and Resistance
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Antibiotic Resistance in Bacteria
- Biomedical Ethics and Regulation
- COVID-19 Clinical Research Studies
- Bacterial biofilms and quorum sensing
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Peptides and Activities
- Monoclonal and Polyclonal Antibodies Research
- Pharmaceutical Economics and Policy
- Tuberculosis Research and Epidemiology
- Ethics in Clinical Research
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Bioinformatics and Genomic Networks
- HIV/AIDS Research and Interventions
- Virology and Viral Diseases
Istituto Superiore di Sanità
2004-2022
Ministero della Salute
2017
Istituti Fisioterapici Ospitalieri
2010
San Gallicano Hospital
2010
Although HAART suppresses HIV replication, it is often unable to restore immune homeostasis. Consequently, non-AIDS-defining diseases are increasingly seen in treated individuals. This attributed persistent virus expression reservoirs and cell activation. Of note, CD4+ T cells monocyte-macrophages of virologically-suppressed individuals, there continued multi-spliced transcripts encoding regulatory proteins. Among them, Tat essential for gene either primary infection or reactivation during...
The human immunodeficiency virus (HIV) type 1 Tat protein plays a key role in the life cycle of and pathogenesis is highly conserved among HIV subtypes. On basis this safety, immunogenicity, efficacy findings monkeys, being tested as vaccine phase trials. Here, we evaluated incidence risk progression to advanced disease by anti-Tat serostatus cohort 252 HIV-1 seroconverters. was lower anti-Tat-positive subjects than anti-Tat-negative subjects. Progression faster persistently transiently...
We determined immune cross-recognition and the degree of Tat conservation in patients infected by local human immunodeficiency virus (HIV) type 1 strains. The data indicated a similar prevalence total epitope-specific anti-Tat IgG 578 serum samples from HIV-infected Italian (n=302), Ugandan (n=139), South African (n=137) subjects, using same B clade protein that is being used vaccine trials. In particular, antibodies were detected 13.2%, 10.8%, 13.9% HIV-1-infected individuals Italy, Uganda,...
The continuing rise in global antimicrobial resistance is seen by many governments and international organizations as a major threat to worldwide health. This means that publications have already described the problems concerning overuse of currently available antibiotics potential solutions this crisis, including development new alternatives antibiotics. However, manuscript, authors approach subject increasing from two perspectives not normally covered previous publications, namely ethical...
Little information is available on circulating human immunodeficiency virus (HIV) subtypes and resistance to antiretroviral drugs in Albania. To fill this gap, we studied 72 plasma samples from HIV-infected individuals throughout the country. Subtype classification genotypic analysis were performed HIV pol gene region. The was successfully 66 (91.6%) showed that 43 (65.2%) strains non-B (mostly subtype A, as determined by of sequences). No major mutations protease found, whereas reverse...
Campylobacter is one of the major foodborne pathogens concern in its growing trend antimicrobial resistance. C. jejuni and coli are causative agents, with contributing to most cases approximately 90% world. Infection transmitted humans due consumption contaminated food water. Campylobacteriosis caused by commonly presented severe diarrhoea, abdominal pain, fever, headache, nausea, vomiting some extreme resulting Guillain–Barré syndrome (GBS) acute flaccid paralysis....