A5025446538- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Vibrio bacteria research studies
- Infections and bacterial resistance
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Biochemical and Structural Characterization
- Enterobacteriaceae and Cronobacter Research
- COVID-19 Clinical Research Studies
- Aquaculture disease management and microbiota
- Genomics and Phylogenetic Studies
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Pharmaceutical and Antibiotic Environmental Impacts
- Escherichia coli research studies
- Microbial infections and disease research
- Cystic Fibrosis Research Advances
- COVID-19 diagnosis using AI
- Infectious Diseases and Mycology
University of Khartoum
2018-2023
MRC Clinical Trials Unit at UCL
2023
University College London
2023
Carbapenem resistant
Abstract Background Antimicrobial resistance (AMR) poses a complex threat to global health security and universal coverage. Recently, nosocomial infections with carbapenemase-producing Gram-negative bacilli (GNB) is increasing worldwide. We report the molecular characterization detection of genes associated carbapenemase producing Gram negative bacteria isolated from hospitalized patients at Soba University Hospital (SUH) in Khartoum State, Sudan. Results Between October 2016 February 2017,...
Hypervirulent K. pneumoniae (hvKP) strains possess distinct characteristics such as hypermucoviscosity, unique serotypes, and virulence factors associated with high pathogenicity. To better understand the genomic profile of isolated hvKP strain, data were compared to genomes hypervirulent typical strains. The strain was from a patient recurrent urinary tract infection, then string test used for detection hypermucoviscosity phenotype. Whole-genome sequencing conducted using Illumina,...
The presence of antimicrobial-resistance genes (ARGs) in mobile genetic elements (MGEs) facilitates the rapid development and dissemination multidrug-resistant bacteria, which represents a serious problem for human health. This is One Health study aims to investigate co-occurrence antimicrobial resistance determinants among clinical environmental isolates K. pneumoniae E. coli. Various bioinformatics tools were used elucidate bacterial strains’ ID, resistome, virulome, MGEs, phylogeny 42...
Though serodiagnosis of actinomycetoma is established, that eumycetoma due to Madurella mycetomatis limited because lack pure antigen. Reliable rapid tests are needed make an accurate timely diagnosis. The purpose this study detect antigen parts M. mycetomatis, which act specifically with antibodies.Cytoplasmic was prepared from molecularly identified cultures by sonication, ultracentrifugation, dried, weighed and appropriately reconstituted. cytoplasmic were separated using 12% sodium...
Introduction The emergence of bacterial pathogens in environmental hosts represents a major risk to public health. This study aimed at characterizing seven novel strains K. quasipneumoniae using genomic approach which was misidentified by phenotypic methods previous batch 27 species thought be pneumoniae . Methods Whole-genome sequencing performed the Illumina platform, and generated raw reads were de novo assembled. Comparative genomic, resistome, virulome, mobilome, phylogeny then...
<ns3:p><ns3:bold>Background: </ns3:bold>Antimicrobial resistance (AMR) among gram-negative bacilli is a global health problem. Surveillance of AMR required to advise on empirical antimicrobial therapy. This study aimed at evaluating the frequency and patterns isolates from patients treated in eight hospitals Khartoum State, Sudan.</ns3:p><ns3:p> <ns3:bold>Methods: </ns3:bold>A cross-sectional laboratory-based was conducted over 6 months period Microbiology Department, Soba University...
Staphylococcus epidermidis is part of the normal human flora that has recently become an important opportunistic pathogen causing nosocomial infections and tends to be multidrug-resistant. In this investigation, we aimed study genomic characteristics methicillin-resistant S. isolated from clinical specimens. Three isolates were identified using biochemical tests evaluated for drug susceptibility. Genomic DNA sequences obtained Illumina, processed analysis various bioinformatics tools. The...
Abstract Background: Antimicrobial resistance (AMR) poses a threat to global health security. Whilst over the past decade, there has been an increase in reports of nosocomial infections globally caused by carbapenem resistant Gram-negative bacilli (GNB), data from Africa have scanty. We performed study genes among GNB isolated patients treated hospitals Khartoum state, Sudan. Methods: A cross-sectional was conducted at Soba University Hospital (SUH) and Institute Endemic Diseases, for period...
<ns3:p><ns3:bold>Background:</ns3:bold> Non-lactose-fermenting gram-negative bacilli (NLFGNB) have become significant nosocomial pathogens and often exhibit intrinsic multidrug resistance. Sequencing of 16s rRNA genes could be utilized for robust identification NLFGNB. This study aimed to identify resistant NLFGNB associated with hospital-acquired infections using sequencing detect the extended-spectrum β-lactamase (ESBL) isolates in Soba Hospital, Khartoum State, Sudan.</ns3:p><ns3:p>...
Abstract Background Patients who develop severe illness due to COVID-19 are more likely be admitted hospital and acquire bacterial co-infections, therefore the WHO recommends empiric treatment with antibiotics. Few reports have addressed impact of management on emergence nosocomial antimicrobial resistance (AMR) in resource constrained settings. This study aimed ascertain whether being a ward (with infection) compared non-COVID-19 (as negative patient) was associated change prevalence...
Campylobacter is one of the major foodborne pathogens concern in its growing trend antimicrobial resistance. C. jejuni and coli are causative agents, with contributing to most cases approximately 90% world. Infection transmitted humans due consumption contaminated food water. Campylobacteriosis caused by commonly presented severe diarrhoea, abdominal pain, fever, headache, nausea, vomiting some extreme resulting Guillain&ndash;Barr&eacute; syndrome (GBS) acute flaccid paralysis....
Abstract Background: Antimicrobial resistance (AMR) poses a threat to global health security. Whilst over the past decade, there has been an increase in reports of nosocomial infections globally caused by carbapenem resistant Gram-negative bacilli (GNB). This study aimed detect and characterize Gram negative bacteria isolated from hospitalized patients Soba University Hospital (SUH) Khartoum State, Sudan Results: A total 206 GNB isolates different clinical specimens were obtained...
Background Antimicrobial resistance (AMR) among Gram-negative bacilli is a global health problem. Surveillance of AMR required to advise on empirical antimicrobial therapy. This study aimed at evaluating the frequency and patterns isolates from patients treated in eight hospitals Khartoum State, Sudan. Methods A cross-sectional laboratory based was conducted over six months period microbiology department, Soba University Hospital, All blood, urine, wound, sputum during were included. Results...
Abstract Background Carbapenems are broad-spectrum β-lactam antibiotics widely prescribed for the treatment of multidrug-resistant gram negative bacilli in systemic infections. In past ten years Carbapenem resistance among gram-negative is rapidly expanding across nosocomial infection isolates. This study was conducted to determine prevalence and characterize genes Gram (GNB) isolated from patients treated hospitals Khartoum state, Sudan.Methods A cross-sectional laboratory based over six...
Abstract Background Patients who develop serious illness due to COVID-19 are more likely have bacterial coinfections, for which WHO recommends treatment with antibiotics. As a result, many countries observing change in antimicrobial stewardship (AMS), addition changes infection prevention and control (IPC) practices such as the use of personal protective equipment, on wards. Few data its impact nosocomial infections resistance (AMR) available from low middle-income (LMICs). these often high...
Abstract Background: Antimicrobial resistance (AMR) poses a complex threat to global health security and universal coverage. Over recent decades, there has been an increase globally in reports of nosocomial infections caused by carbapenem-resistant Gram-negative bacilli (GNB). We aimed explore the molecular characterization detection genes associated with carbapenem producing Gram negative bacteria isolated from hospitalized patients Soba University Hospital (SUH) Khartoum State, Sudan....