A5020774943- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Animal Diversity and Health Studies
- Mosquito-borne diseases and control
- Circular RNAs in diseases
- Foot and Ankle Surgery
- Gestational Diabetes Research and Management
- Renal and related cancers
- Antibiotic Resistance in Bacteria
- Viral Infections and Vectors
- Pluripotent Stem Cells Research
- Oral and Maxillofacial Pathology
- COVID-19 Clinical Research Studies
- Pregnancy-related medical research
- Chronic Disease Management Strategies
- Epigenetics and DNA Methylation
- Pelvic and Acetabular Injuries
- Cancer, Hypoxia, and Metabolism
- Reproductive Biology and Fertility
- SARS-CoV-2 and COVID-19 Research
- Helicobacter pylori-related gastroenterology studies
- Computational Drug Discovery Methods
- Hepatitis C virus research
King Abdulaziz University
2016-2025
Azienda Unita' Sanitaria Locale Di Modena
2025
University of Ulster
2025
Ministry of Defence
2025
University of Ferrara
2025
Najran University
2025
Riyadh Armed Forces Hospital
2025
King Fahd Medical City
2025
Mansoura University
2024
Al Baha University
2023-2024
Cross talk, mediated by exosomes, between normal stem cells and cancer (CSCs) in the tumor microenvironment has been given less attention so far. In addition, no publications are available literature that address vivo impact of exosomes derived from CSCs mesenchymal (MSCs) on progression long-term hepatocellular carcinoma (HCC). Herein, we hypothesized transfer among HCC could either induce or inhibit growth metastasis depending their source. To check this hypothesis, investigated effect...
Abstract Colorectal cancer (CRC) is the third most common affecting people. The discovery of new, non-invasive, specific, and sensitive molecular biomarkers for CRC may assist in diagnosis support therapeutic decision making. Exosomal miRNAs have been demonstrated carcinogenesis development, which makes these strong CRC. Deep sequencing allows a robust high-throughput informatics investigation types abundance exosomal miRNAs. Thus, can be efficiently examined as diagnostic disease screening....
Abstract The success of the Saudi Human Genome Program (SHGP), one top ten genomic programs worldwide, is highly dependent on population embracing concept participating in genetic testing. However, data sharing and artificial intelligence (AI) genomics are critical public issues medical care scientific research. present study was aimed to examine awareness, knowledge, attitude society towards SHGP, privacy resulting from role AI analysis regulations. Results a questionnaire survey with 804...
Hypervirulent K. pneumoniae (hvKP) strains possess distinct characteristics such as hypermucoviscosity, unique serotypes, and virulence factors associated with high pathogenicity. To better understand the genomic profile of isolated hvKP strain, data were compared to genomes hypervirulent typical strains. The strain was from a patient recurrent urinary tract infection, then string test used for detection hypermucoviscosity phenotype. Whole-genome sequencing conducted using Illumina,...
Introduction: Zinc oxide nanoparticles (ZnO NPs) have recently attracted attention as potential anti-cancer agents. To the best of our knowledge, toxicity ZnO NPs against human chronic myeloid leukemia cells (K562 cell line) has not been studied using transcriptomics approach. Objective: The goals this study were to evaluate capability induce apoptosis in cells) and investigate putative mechanisms action. Methods: We used viability assay flowcytometry coupled with Annexin V-FITC propidium...
Abstract The BLM helicase protein plays a vital role in DNA replication and the maintenance of genomic integrity. Variation gene resulted defects repair mechanism was reported to be associated with Bloom syndrome (BS) cancer. Despite extensive investigation proteins humans, no attempt has previously been made comprehensively analyse single nucleotide polymorphism (SNPs) gene. In this study, comprehensive analysis SNPs on performed identify, characterize validate pathogenic using...
The presence of antimicrobial-resistance genes (ARGs) in mobile genetic elements (MGEs) facilitates the rapid development and dissemination multidrug-resistant bacteria, which represents a serious problem for human health. This is One Health study aims to investigate co-occurrence antimicrobial resistance determinants among clinical environmental isolates K. pneumoniae E. coli. Various bioinformatics tools were used elucidate bacterial strains’ ID, resistome, virulome, MGEs, phylogeny 42...
An imbalance in angiogenic growth factors and poor utero-placental perfusion are strongly associated with preeclampsia. The reduced (RUPP) model that mimics insufficient placental is used to study aim of this was develop a refined RUPP C57Bl/6 J mice test the efficacy MZe786 as potential inhibitor soluble Flt-1 for preeclampsia therapy. Murine (mRUPP) induced through bilateral ligation ovarian arteries at E11.5 resulted typical symptoms including increase mean arterial pressure (MAP), kidney...
Rutin has been well recognized for possessing numerous pharmacological and biological activities in several human cancer cells. This research addressed the inhibitory potential of rutin against Jab1 oncogene SiHa cells, which is known to inactivate various tumor suppressor proteins including p53 p27. Further, efficacy via expression modulation cervical not yet elucidated. Hence, we hypothesized that could exhibit strong and, thereby, induce significant growth arrest cells a dose-dependent...
Extracellular vesicles (EVs) carry important biomolecules, including metabolites, and contribute to the spread pathogenesis of some viruses. However, date, limited data are available on EV metabolite content that might play a crucial role during infection with SARS-CoV-2 virus. Therefore, this study aimed perform untargeted metabolomics identify key metabolites associated pathways present in EVs, isolated from serum COVID-19 patients. The results showed presence antivirals antibiotics such...
Merkel cell carcinoma (MCC) is a rare form of aggressive skin cancer mainly caused by polyomavirus (MCPyV). Most MCC tumors express MCPyV large T (LT) antigens and play an important role in the growth-promoting activities oncoproteins. Truncated LT promotes tumorigenicity as well host proliferation activating viral replication machinery, inhibition this protein humans drastically lowers cellular growth linked to corresponding cancer. Our study was designed with aim identifying small...
Gingival recession is a prevalent condition with significant aesthetic and functional consequences. This case report about 36-year-old female who presented multiple Miller's Class I gingival defects affecting teeth from 22 to 25. A modified envelope flap technique was utilized, incorporating connective tissue graft (CTG) harvested the palate supplemented enamel matrix derivatives (EMD). The treatment resulted in root coverage all treated sites. patient reported high satisfaction...