Stefania Bellino
A5114376963- HIV Research and Treatment
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- COVID-19 Pandemic Impacts
- HIV/AIDS drug development and treatment
- Virology and Viral Diseases
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Neuroendocrine Tumor Research Advances
- Herpesvirus Infections and Treatments
- Data-Driven Disease Surveillance
- Lung Cancer Research Studies
- COVID-19 Impact on Reproduction
- Viral gastroenteritis research and epidemiology
- Gestational Trophoblastic Disease Studies
- Human Mobility and Location-Based Analysis
Istituto Superiore di Sanità
2016-2025
National Institute of Health
2020
University of Insubria
2020
Fondazione Bruno Kessler
2020
European Centre for Disease Prevention and Control
2020
Indiana University Bloomington
2020
Northeastern University
2020
Informa (Italy)
2000
OBJECTIVES: To describe the epidemiological and clinical characteristics of coronavirus disease (COVID-19) pediatric patients aged <18 years in Italy. METHODS: Data from national case-based surveillance system confirmed COVID-19 infections until May 8, 2020, were analyzed. Demographic subjects summarized by age groups (0–1, 2–6, 7–12, 13–18 years), risk factors for severity evaluated using a multilevel (clustered region) multivariable logistic regression model. Furthermore, comparison...
Background On 20 February 2020, a locally acquired coronavirus disease (COVID-19) case was detected in Lombardy, Italy. This the first signal of ongoing transmission severe acute respiratory syndrome 2 (SARS-CoV-2) country. The number cases Italy increased rapidly and country became Europe to experience SARS-CoV-2 outbreak. Aim Our aim describe epidemiology dynamics COVID-19 amid control measures. Methods We analysed all RT-PCR-confirmed reported national integrated surveillance system until...
Abstract Background Aim of the present study is to describe characteristics COVID-19-related deaths and compare clinical phenotype course occurring in adults (<65 years) older (≥65 years). Method Medical charts 3,032 patients dying with COVID-19 Italy (368 aged < 65 years 2,664 ≥65 were revised extract information on demographics, preexisting comorbidities, in-hospital complications leading death. Results Older presented a higher number comorbidities compared those <65...
SUMMARY Background In February 2020, a locally-acquired COVID-19 case was detected in Lombardia, Italy. This the first signal of ongoing transmission SARS-CoV-2 country. The outbreak rapidly escalated to national level epidemic, amid WHO declaration pandemic. Methods We analysed data from case-based integrated surveillance system all RT-PCR confirmed infections as March 24 th collected Italian regions and autonomous provinces. Here we provide descriptive epidemiological summary on 62,843...
SARS-CoV-2 infection is heterogeneous in clinical presentation and disease evolution. To investigate whether immune response to the virus can be influenced by genetic factors, we compared HLA AB0 frequencies organ transplant recipients waitlisted patients according presence or absence of infection.A retrospective analysis was performed on an Italian cohort composed transplanted a January 2002 March 2020 time frame. Data from this were merged with registry COVID+ subjects, evaluating status...
On March 11, 2020, Italy imposed a national lockdown to curtail the spread of severe acute respiratory syndrome coronavirus 2. We estimate that, 14 days after lockdown, net reproduction number had dropped below 1 and remained stable at »0.76 (95% CI 0.67-0.85) in all regions for >3 following weeks.
Although HAART suppresses HIV replication, it is often unable to restore immune homeostasis. Consequently, non-AIDS-defining diseases are increasingly seen in treated individuals. This attributed persistent virus expression reservoirs and cell activation. Of note, CD4+ T cells monocyte-macrophages of virologically-suppressed individuals, there continued multi-spliced transcripts encoding regulatory proteins. Among them, Tat essential for gene either primary infection or reactivation during...
International literature suggests that disadvantaged groups are at higher risk of morbidity and mortality from SARS-CoV-2 infection due to poorer living/working conditions barriers healthcare access. Yet, date, there is no evidence this disproportionate impact on non-national individuals, including economic migrants, short-term travellers refugees.We analyzed data the Italian surveillance system all COVID-19 laboratory-confirmed cases tested positive beginning outbreak (20th February) 19th...
Post-herpetic neuralgia is the most challenging and debilitating complication of herpes zoster in immunocompetent host. Because effect treatment disappointing once syndrome has developed, it important to know which factors predict post-herpetic occurrence facilitate selection patients with a higher risk developing undertake preventative strategies. The present study aimed at identifying demographic, clinical psychosocial correlates sample 219 patients, who were examined by dermatologists...
Tat is an early regulatory protein that plays a major role in human HIV-1 replication and AIDS pathogenesis, therefore, it represents key target for the host immune response. In natural infection, however, Abs against are produced only by small fraction (approximately 20%) of asymptomatic individuals rarely seen progressors, suggesting may possess properties diverting adaptive immunity from generating humoral responses. Here we show Th1-type T cell response predominant over Th2-type B...
Use of Env in HIV vaccine development has been disappointing. Here we show that, the presence a biologically active Tat subunit vaccine, trimeric protein prevents monkeys virus spread from portal entry to regional lymph nodes. This appears be due specific interactions between and spikes that form novel complex favoring R5 or X4 productive infection dendritic cells (DCs) via an integrin-mediated pathway. These effects do not require Tat-transactivation activity are blocked by anti-integrin...
The phase II multicenter, randomized, open label, therapeutic trial (ISS T-002, Clinicaltrials.gov NCT00751595) was aimed at evaluating the immunogenicity and safety of biologically active HIV-1 Tat protein administered 7.5 or 30 μg, given 3 5 times monthly, exploring immunological virological disease biomarkers. study duration 48 weeks, however, vaccinees were followed until last enrolled subject reached weeks. Reported are final data up to 144 weeks follow-up. ISS T-002 conducted in 11...
BackgroundIn high-income countries, hepatitis E virus (HEV) infection is mainly a zoonosis. However, it also transfusion-transmissible and some but not Italy, have introduced HEV screening for blood donations.AimWe assessed prevalence risk factors in nationwide sample of Italian donors.MethodsWe selected 107 establishments (BE) distributed the 20 regions by stratified two-stage design invited them to participate study. Donors were tested anti-HEV IgG IgM RNA. Sociodemographic data collected...
The relation between meteorological factors and COVID-19 spread remains uncertain, particularly with regard to the role of temperature, relative humidity solar ultraviolet (UV) radiation. To assess this relation, we investigated disease within Italy during 2020. pandemic had a large early impact in Italy, 2020 effects vaccination viral variants not yet complicated dynamics. We used non-linear, spline-based Poisson regression modeled UV humidity, adjusting for mobility patterns additional...
Human immunodeficiency virus protease inhibitors (HIV-PIs), such as indinavir and saquinavir, have been shown to block angiogenesis tumor cell invasion induce apoptosis growth arrest, respectively, both in vitro vivo. These findings suggested that HIV-PIs or their analogues can be used antitumor drugs. To this regard, saquinavir were assessed for ability inhibit vivo the of highly prevalent human tumors, lung, breast, colon hepatic adenocarcinomas. We show here significantly inhibited all...
Tat is a key HIV-1 virulence factor, which plays pivotal roles in virus gene expression, replication, transmission and disease progression. After release, extracellular accumulates tissues exerts effects on both the immune system, promoting activation spreading while disabling host defense. In particular, binds Env spikes particles forming entry complex, favors infection of dendritic cells efficient to T via RGD-binding integrins. also shields CCR5-binding sites rendering ineffective...
Treatment of human immunodeficiency virus (HIV)-infected women with the highly active antiretroviral therapy (HAART) has reduced onset uterine cervical intraepithelial neoplasia (CIN), and halted its progression to carcinoma. We others demonstrated that HIV protease inhibitors (HIV-PIs) used in HAART can exert direct antitumour activities also HIV-free preclinical or clinical models. As carcinoma is a leading cause death independently infection, herein we assessed impact therapeutic...
Abstract Background Among the unknowns posed by coronavirus disease 2019 (COVID-19) outbreak, role of biological sex to explain susceptibility and progression is still a matter debate, with limited sex-disaggregated data available. Methods A retrospective analysis was performed assess if differences exist in clinical manifestations transitions care among hospitalized individuals dying laboratory-confirmed SARS-CoV-2 infection Italy (February 27–June 11, 2020). Clinical characteristics times...