A5072944837- Prion Diseases and Protein Misfolding
- Long-Term Effects of COVID-19
- Alcoholism and Thiamine Deficiency
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 Clinical Research Studies
- Neurological diseases and metabolism
- Infectious Encephalopathies and Encephalitis
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Nosocomial Infections in ICU
- Peripheral Neuropathies and Disorders
- Intensive Care Unit Cognitive Disorders
- Trigeminal Neuralgia and Treatments
- Antibiotic Use and Resistance
- Vestibular and auditory disorders
- Cardiovascular Syncope and Autonomic Disorders
- Chronic Disease Management Strategies
- Pneumonia and Respiratory Infections
- Trace Elements in Health
- Leprosy Research and Treatment
- Neurological disorders and treatments
- Migraine and Headache Studies
- Sympathectomy and Hyperhidrosis Treatments
- Zoonotic diseases and public health
Istituto Superiore di Sanità
2014-2024
Sapienza University of Rome
2006-2023
National Institute of Health
2020
Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguishing treatable from untreatable rapidly progressive dementias future therapeutic trials. This early becoming possible using the real-time quaking-induced conversion (RT-QuIC) seeding assay, which detects minute amounts disease-specific pathologic prion protein cerebrospinal fluid (CSF) or olfactory mucosa (OM) samples.To develop an algorithm CJD by RT-QuIC assay on CSF samples, OM...
Abstract Background Aim of the present study is to describe characteristics COVID-19-related deaths and compare clinical phenotype course occurring in adults (<65 years) older (≥65 years). Method Medical charts 3,032 patients dying with COVID-19 Italy (368 aged < 65 years 2,664 ≥65 were revised extract information on demographics, preexisting comorbidities, in-hospital complications leading death. Results Older presented a higher number comorbidities compared those <65...
<h3>Importance</h3> Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly lethal disease. Rapid, accurate diagnosis imperative for epidemiological surveillance and public health activities to exclude treatable differentials facilitate supportive care. In 2017, the International CJD Surveillance Network diagnostic criteria were revised incorporate cortical ribboning on magnetic resonance imaging real-time quaking-induced conversion (RT-QuIC) assay, developments that require multicenter...
Abstract Background Among the unknowns posed by coronavirus disease 2019 (COVID-19) outbreak, role of biological sex to explain susceptibility and progression is still a matter debate, with limited sex-disaggregated data available. Methods A retrospective analysis was performed assess if differences exist in clinical manifestations transitions care among hospitalized individuals dying laboratory-confirmed SARS-CoV-2 infection Italy (February 27–June 11, 2020). Clinical characteristics times...
Introduction We aimed at exploring the proportion of patients dying with COVID-19 and concomitant dementia in Italy, as well their clinical characteristics trajectories care. Methods The COVID-19-related deaths occurring people deceased individuals according to status were explored by considering medical charts a representative sample Italian hospitals (n = 2621). Results A total 415 identified study population, accounting for 15.8% overall deaths. Patients less frequently presented cough,...
Background The introduction of the prion Real-Time Quaking-Induced Conversion assay (RT-QuIC) has led to a revision diagnostic criteria for sporadic Creutzfeldt-Jakob disease (sCJD). Validation studies are needed amended criteria, especially their value in clinical setting. Methods We studied 1250 patients with suspected CJD referred diagnosis two Italian reference centres between 2010 and 2020. Focusing on first assessment, we compared old that different combinations variables biomarker...
Abstract The current classification of sporadic Creutzfeldt–Jakob disease identifies six major subtypes mainly defined by the combination genotype at polymorphic codon 129 (methionine/M or valine/V) prion protein gene and type (1 2) misfolded accumulating in brain (e.g. MM1, MM2, MV1, MV2, etc.). Here, we systematically characterized clinical histo-molecular features associated with third prevalent subtype, MV2 subtype kuru plaques (MV2K), most extensive series collected to date. We...
Abstract Background Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 not been investigated. Methods A random sample 6085 individuals Italy who died in-hospital confirmed between February and December 2020 were included. Observed expected (O/E) ratios disease pairs computed logistic regression models used determine the association O/E values ≥ 1.5. Results Six diseases exhibited 1.5 statistically significant...
Several recent studies reported on some patients developing Creutzfeldt–Jakob disease (CJD) following coronavirus 2019, but, to the best of our knowledge, this case is first in Italy an onset a CJD genetic form (gCJD) immediately after COVID-19 infection. We present 51-year-old woman with positive family history for CJD, who, two months mild SARS-CoV-2 infection, presented rapidly progressing dementia diagnosed as through clinical features, imaging, electroencephalography, and cerebrospinal...
<b><i>Background:</i></b> Sporadic Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative caused by prions that randomly distributed in all countries, with an overall yearly mortality rate of about 1–2 cases per million people. On few occasions, however, sporadic CJD occurred higher than expected rates, but further investigations failed to recognize any convincing causal link. In Italy, cluster analyses have not been performed previously....
We report a case of rapidly evolving neurological disease in patient with neuropathological lesions Creutzfeldt‐Jakob (CJD), Lewy body dementia (LBD), chronic subcortical vascular encephalopathy and meningothelial meningioma. The coexistence severe multiple pathologies single strengthens the need to perform accurate clinical differential diagnoses progressive dementias.
it has been just over three years since SARS-CoV-2 viral infection was first known as causing severe acute and highly transmissible respiratory syndrome coronavirus. During one of the worst global pandemics last century, caused by COVID-19 disease, under persistent immune pressure exerted newest vaccines, virus is fastly mutating becoming less severe, but more contagious. On other hand, some studies [1,2,3] indicate that elderly patients or those who have reported a virulent episode this...
We presented a four-case series of COVID-19 related deaths occurred in patients with Guillain-Barré syndrome (GBS) between February 2020 and January 2022 Italy.They were extracted from 8,436 medical charts dying. All cases, ranged 48-73 years, showed classical GBS clinical onset - limb weakness, sensory deficits, hypoareflexia three them admitted intensive care unit (ICU) for ventilator support.The cerebrospinal fluid showing albumin-cytological dissociation was performed two cases. Nerve...
Genetic Creutzfeldt–Jakob disease (gCJD) associated with the V180I mutation in prion protein (PrP) gene (PRNP) phase residue 129M is most frequent cause of gCJD East Asia, whereas it quite uncommon Caucasians. We report on a patient rare V180I-129V haplotype, showing an unusually long duration and characteristic pathological PrP (PrPSc) glycotype. Family members carrying were fully asymptomatic, as commonly observed this mutation. Neuropathological examination showed lesion pattern...
Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder typically characterized by progressive dementia associated with myoclonus, cerebellar and other focal neurological signs. Electroencephalogram, brain MRI cerebrospinal fluid (CSF) analyses are helpful diagnostic tools, but diagnosis in patients atypical presenting signs often difficult to make. A 55-year-old woman developed disorientation, drowsiness motor after traumatic injury due an accidental fall. In two weeks, her...
Introduction Clustering of sporadic Creutzfeldt-Jakob disease (CJD), a rare fatal neurodegenerative with unknown etiology, was investigated in an Italian region. Methods Occurrence CJD between 1993 and 2014 analyzed by municipality Apulia Region (Italy) using data provided the Registry Bureau Statistics. Expected cases were obtained internal indirect standardization based on age gender specific regional incidence rates. We fitted Bayesian hierarchical models spatially structured unstructured...
it has been just over three years since SARS-CoV-2 viral infection was first known as causing severe acute and highly transmissible respiratory syndrome coronavirus. During one of the worst global pandemics last century, caused by COVID-19 disease, under persistent immune pressure exerted newest vaccines, virus is fastly mutating becoming less severe, but more contagious. On other hand, some studies [1,2,3] indicate that elderly patients or those who have reported a virulent episode this...