A5006734763- Prion Diseases and Protein Misfolding
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- HIV/AIDS Research and Interventions
- Hemophilia Treatment and Research
- Dementia and Cognitive Impairment Research
- Hepatitis C virus research
- Ovarian function and disorders
- Multiple Sclerosis Research Studies
- Neuroendocrine regulation and behavior
- Reproductive Biology and Fertility
- Family and Disability Support Research
- Trace Elements in Health
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Child Development and Digital Technology
- RNA regulation and disease
- Infant Health and Development
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- Muscle activation and electromyography studies
- Assisted Reproductive Technology and Twin Pregnancy
- EEG and Brain-Computer Interfaces
Istituto Superiore di Sanità
2014-2023
Fondazione Santa Lucia
2023
Weatherford College
2023
University of Messina
2023
Instituto de Salud Carlos III
2023
Ministero della Salute
2023
Neuroscience Institute
2021
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2011
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2011
LFB (France)
2011
Intrathecal antibody production is a hallmark of multiple sclerosis and humoral immunity thought to play an important role in the inflammatory response development demyelinated lesions. The presence lymphoid follicle-like structures cerebral meninges some patients indicates that B-cell maturation can be sustained locally within CNS contribute establishment compartmentalized immune response. In this study we examined distribution ectopic follicles cases with primary secondary progressive...
There is no generally accepted standard chemotherapy in treatment of advanced and recurrent endometrial carcinoma. Cisplatin doxorubicin with or without cyclophosphamide are widely used. Response rates have improved combination compared single-agent therapy. A platinum analog seems to be an important part the regimen. Since few patients cured from their disease since duration response short, further improvement this therapy warranted. During past years, taxanes (paclitaxel) being added prior...
To estimate the effectiveness of mRNA vaccines against SARS-CoV-2 infection and severe covid-19 at different time after vaccination.
Abstract Some key behavioural traits of Autism Spectrum Disorders (ASD) have been hypothesized to be due impairments in the early activation subcortical orienting mechanisms, which typical development bias newborns orient relevant social visual stimuli. A challenge testing this hypothesis is that autism usually not diagnosed until a child at least 3 years old. Here, we circumvented difficulty by studying for very first time, predispositions pay attention stimuli with high familial risk...
<h3>Importance</h3> Convalescent plasma (CP) has been generally unsuccessful in preventing worsening of respiratory failure or death hospitalized patients with COVID-19 pneumonia. <h3>Objective</h3> To evaluate the efficacy CP plus standard therapy (ST) vs ST alone <h3>Design, Setting, and Participants</h3> This prospective, open-label, randomized clinical trial enrolled (1:1 ratio) pneumonia to receive between July 15 December 8, 2020, at 27 sites Italy. Hospitalized adults a partial...
Abstract Background This nationwide study aimed to estimate Autism Spectrum Disorder (ASD) prevalence in 7–9-year-old Italian children. Promoted by Italy's Ministry of Health and coordinated the National Observatory for at Institute Health, it covered schools northern (Lecco Monza-Brianza), central (Rome its province), southern (Palermo province) regions from February 24, 2016, 23, 2018, using a multi-stage approach defined European Union's ASD network. Methods Phase one identified...
Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for accurate diagnosis this neurodegenerative disorder. Circulating miRNAs have been reported as promising disorders and processes affecting central nervous system, especially in aging. The objective study was to evaluate if some circulating linked with apoptosis (miR-29b-3p, miR-34a-5p, miR-16-5p, miR-17-5p, miR-107, miR-19b-3p, let-7b-5p, miR-26b-5p, 127-3p) were able distinguish...
The levels of 2 arachidonic acid metabolites formed either by enzymatic activity cyclooxygenase, i.e. prostaglandin E2 (PGE2), or free radical-catalyzed peroxidation, F2-isoprostane 8-epi-prostaglandin F2α (8-epi-PGF2α), were measured in the CSF subjects with sporadic and familial Creutzfeldt–Jakob disease (CJD) brain homogenates scrapie-infected mice. both increased CJD (n = 52) 10) patients when compared a group noninflammatory disorders. Similarly, PGE2 8-epi-PGF2α higher obtained from...
BACKGROUND The role of high resolution pulsed and color Doppler ultrasound in the differential diagnosis benign malignant lymphadenopathy is still unclear. METHODS High was used prospectively to investigate superficial lymph node enlargement 71 patients undergoing surgical biopsy at onset lymphadenopathy. aim this study define, multivariate analysis, ultrasonographic parameters useful RESULTS Volume, vascularization score, pulsatility index, resistive index were significantly higher 53 nodes...
<b>Objective: </b> To assess the incidence and mortality rates of genetic transmissible spongiform encephalopathy (TSE) diseases in Italy. <b>Methods: The authors have sequenced prion protein gene (<i>PRNP</i>) 643 patients referred to Italian Registry Creutzfeldt-Jakob disease (CJD) related disorders between 1993 2002. Crude age- sex-specific were calculated. Differences morbidity from TSE 20 regions assessed by standardized ratio (SMR). <b>Results: A total 130 cases classified as with a...
The aim of this study was to investigate whether attention may be specifically impaired in Alzheimer's disease from the early stages disease. Subgroups patients with different types mild cognitive impairment were selected according standard criteria. Patients and controls given tasks exploring various subcomponents executive functions. Only subgroups characterized by memory disorders obtained lower scores than on tasks. On basis Clinical Dementia Rating at 1-year follow-up, redistributed...
BACKGROUND: The occurrence of transfusion transmissions variant Creutzfeldt‐Jakob disease (CJD) cases has reawakened attention to the possible similar risk posed by other forms CJD. STUDY DESIGN AND METHODS: CJD with a definite or probable diagnosis (sporadic CJD, n = 741; genetic 175) and no‐CJD patients alternative (n 482) available blood history were included in study. exposure occurring more than 10 years before onset for some confounding factors was evaluated calculating crude odds...
Caffeine is a nonselective adenosine receptor antagonist; chronic consumption has proved protective toward neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. The present study was designed to determine whether caffeine intake affected survival and/or motor performance in transgenic model of amyotrophic lateral sclerosis (ALS). SOD1(G93A) mice received through drinking water from 70 days age until death. Body weight, were evaluated. Furthermore, the expression A(2A)...
To assess the real-world impact of vaccines on COVID-19 related outcomes, we analysed data from over 7 million recipients at least one vaccine dose in Italy. Taking 0–14 days post-first as reference, SARS-CoV-2 infection risk subsequently decreased, reaching a reduction by 78% (incidence rate ratios (IRR): 0.22; 95% CI: 0.21–0.24) 43–49 dose. Similarly, hospitalisation and death risks with 89% (IRR: 0.11; 0.09–0.15) 93% 0.07; 0.04–0.11) reductions 36–42 Our results support ongoing...
The role of age acquisition (AoA) and other variables classically supposed to influence lexical semantic tasks is explored in Alzheimer’s disease (AD) patients. A naming test that included living nonliving items was given patients controls. Measures AoA the were obtained from normal subjects. Living acquired earlier than items. Semipartial correlation analyses performed determine independent contribution each variable naming. “category” (living vs. items) as an factor. It emerged AoA, name...
Abstract Background Stroke is a leading cause of long-term disability. Cost-effective post-stroke rehabilitation programs for upper limb are critically needed. Brain-Computer Interfaces (BCIs) which enable the modulation Electroencephalography (EEG) sensorimotor rhythms promising tools to promote recovery motor function. The “Promotoer” study intends boost application EEG-based BCIs in clinical practice providing evidence short/long-term efficacy enhancing hand functional and quantifiable...
In 2007, we reported a patient with an atypical form of Creutzfeldt-Jakob disease (CJD) heterozygous for methionine-valine (MV) at codon 129 who showed novel pathological prion protein (PrPTSE) conformation glycoform (AG) profile and intraneuronal PrP deposition. the present study, further characterize conformational properties this (PrPTSE MVAG), showing that PrPTSE MVAG is composed multiple conformers biochemical distinct from those type 1 2 MV sporadic CJD (sCJD). Experimental...
Progranulin (PGRN) is a secreted protein expressed ubiquitously throughout the body, including brain, where it localizes in neurons and activated microglia. Loss-of-function mutations GRN gene are an important cause of familial Frontotemporal Lobar Degeneration (FTLD). PGRN has neurotrophic anti-inflammatory activity, neuroprotective several injury conditions, such as oxygen or glucose deprivation, oxidative injury, hypoxic stress. Indeed, we have previously demonstrated that hypoxia induces...
Object and action naming comprehension were tested in frontotemporal dementia (frontal variant, FTD), Alzheimer’s disease (AD) controls. Although lower scores obtained by all groups, we can confirm that actions proportionally more impaired FTD. The correlation between deficit severity of was stronger this group than AD. analysis also suggested the disorder different nature FTD (mostly a dysexecutive deficit) AD linguistic disorder). Our explanation is since verbs are supposed to be demanding...
Aim: Some patterns of repetitive movements and their frequency have been proved to distinguish infants with Autism Spectrum Disorders (ASD) from Typical Development (TD) Developmental Delay (DD) 12 months life on. The purpose this study is investigate if a specific repertoire present earlier in life, higher rate duration could differentiate ASD DD TD aged between 6 months. Method: We conducted retrospective analysis video-clips taken home videos compare the Repetitive Movement Episodes...
Gene expression analyses in paired cerebrospinal fluid (CSF) and peripheral blood mononuclear cells (PBMC) from patients with multiple sclerosis (MS) are restrained by the low RNA amounts CSF levels of certain genes. Here, we applied a Taqman-based pre-amplification real-time reverse-transcription polymerase chain reaction (RT-PCR) (PreAmp RT-PCR) to cDNA PBMC MS analyzed genes related immune system function expressed Epstein-Barr virus (EBV), herpesvirus showing strong association MS. Using...
The concentration of the cyclooxygenase product prostaglandin E<sub>2</sub> was sixfold higher in CSF samples from 18 cases variant Creutzfeldt–Jakob disease (CJD) than a group eight subjects with other noninflammatory neurologic diseases, and comparable to those found six patients affected by diseases known inflammatory component. This finding suggests that activity may have role CJD pathogenesis, as previously reported sporadic CJD.