A5090921652- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Long-Term Effects of COVID-19
- Nuclear Receptors and Signaling
- Amyotrophic Lateral Sclerosis Research
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Sexual function and dysfunction studies
- Bioinformatics and Genomic Networks
- Intensive Care Unit Cognitive Disorders
- Sexuality, Behavior, and Technology
- Neurological disorders and treatments
- COVID-19 and Mental Health
- Prion Diseases and Protein Misfolding
- RNA regulation and disease
- COVID-19 diagnosis using AI
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Olfactory and Sensory Function Studies
- GDF15 and Related Biomarkers
Sapienza University of Rome
2014-2025
ASL Roma
2023
Azienda Unita' Sanitaria Locale Di Modena
2023
The Memory Clinic
2012
Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for accurate diagnosis this neurodegenerative disorder. Circulating miRNAs have been reported as promising disorders and processes affecting central nervous system, especially in aging. The objective study was to evaluate if some circulating linked with apoptosis (miR-29b-3p, miR-34a-5p, miR-16-5p, miR-17-5p, miR-107, miR-19b-3p, let-7b-5p, miR-26b-5p, 127-3p) were able distinguish...
Background Despite dementia with Lewy bodies (DLB) being the second most common form of neurodegenerative dementia, more than 80% DLB cases are initially misdiagnosed. Alpha-synuclein (a-syn) and tau species have been detected in peripheral tissues biological fluids patients among different fluids, saliva represent an easely accessible non-invasive source for biomarker detection. Objective This study aimed to investigate salivary a-syn as molecular disease biomarkers, assessing their...
The most frequently used biomarkers to support the diagnosis of Alzheimer’s Disease (AD) are Aβ42, total-Tau, and phospho-tau protein levels in CSF. Moreover, magnetic resonance imaging is assess hippocampal atrophy, 18F-FDG PET identify abnormal brain metabolism, for amyloid deposition. These tests rather complex invasive not easily applicable clinical practice. Circulating non-coding RNAs, which inherently stable easy manage, have been reported as promising central nervous system...
There is very little knowledge regarding the terminal nerve, from its implications in involvement and pathogenesis of certain conditions, to embryological origin. With this review, we try summarize most important evidence on aiming clarify anatomy various functions attributed it, better interpret potential pathological processes. Recent studies have also suggested role control human reproductive behaviors. It has been hypothesized that it plays a unconscious perception specific odors...
Background: Restless legs syndrome (RLS) is a neurological disorder characterized by the urge to move associated with peculiar unpleasant sensations during periods of rest and inactivity that are relieved movement. A few studies analyzed RLS in neurodegenerative diseases such as Alzheimer's Disease (AD). The aim our study was assess prevalence clinical characteristics cohort AD patients. Methods: Three hundred thirty-nine subjects diagnosis were recruited. Cognitive, functional,...
Alzheimer's disease (AD), the most common cause of dementia, typically shows a slow clinical progression over time. 'Rapidly progressive' AD, variant characterized by an aggressive course, exhibits distinct clinical, biological, and neuropathological features. Here, we investigate neuropsychological predictors rapid decline in group mild patients with AD.One hundred fifty-three AD admitted to memory disorder clinic followed for up 3 years were included this study. A comprehensive (NP)...
The missense P39L variant in the prion protein gene (PRNP) has recently been associated with frontotemporal dementia (FTD). Here, we analyzed presence of 761 patients FTD and 719 controls found a single carrier among patients. patient was 67-year-old male, positive family history for dementia, who developed apathy, short term memory deficit, postural instability at 66. Clinical instrumental workup excluded disease. At MRI, bilateral frontal lobe atrophy present. A diagnosis made, mainly...
The term sundowning is used to describe the emergence or worsening of neuropsychiatric symptoms in late afternoon early evening people with dementia.Our aim was evaluate sundowning's prevalence and clinical manifestations among patients attending a tertiary memory clinic investigate its neuropsychological correlates.Patients dementia our were enrolled study. Sundowning identified through specifically designed questionnaire. Sociodemographic features sundowners non-sundowners compared,...
Frontotemporal dementia (FTD) is a degenerative disorder characterized, in its frontal variant, by psychiatric onset, deficits executive functions and sparing of memory visuo-spatial abilities. Studies on abilities FTD Alzheimer's disease (AD) have mainly focused constructional (CA) yielded contrasting data, often depending either the task used or biases clinical selection patients. The aim our study was to evaluate frequency CA impairment FTD-fv AD patients at early stage disease, verify if...
Alzheimer's disease (AD) is characterized by accumulation of toxic amyloid-β (Aβ) in the brain, with neuronal death, and an associated increased Aβ42/40 ratio. Several mutations presenilin 1 (PSEN1), 2 (PSEN2), precursor p
Plasma progranulin (PGRN) levels constitute a potentially invaluable biomarker for neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and, perhaps, Alzheimer's disease (AD). We assessed plasma PGRN in 107 AD patients
Inappropriate sexual behaviors (ISB) represent uncommon and often misdiagnosed clinical disorders among patients with Alzheimer disease. So far, no randomized trials regarding the treatment of ISB in demented people have been conducted, but available data from case series isolated reports suggest efficacy selective serotonin reuptake inhibitors (SSRIs), antipsychotics, antiandrogens, H2-receptor antagonists. Controversial exist on therapeutic influence cholinesterase disorders. In present...
Dementia is one of the most common diseases in elderly people and hundreds thousand new cases per year Alzheimer's disease (AD) are estimated. While recent decade has seen significant advances development novel biomarkers to identify dementias at their early stage, a great effort been recently made able improve differential diagnosis. However, only few potential candidates, mainly detectable cerebrospinal fluid (CSF), have described so far. We searched for miRNAs regulating MAPT translation....
Background: Neurological symptoms (NS) in COVID-19 are related to both acute stage and long-COVID. We explored levels of brain injury biomarkers (NfL GFAP) myeloid activation marker (sCD163) their implications on the CNS. Materials Methods: In hospitalized patients plasma samples were collected at two time points: hospital admission (baseline) three months after discharge (Tpost). Patients stratified according severity based respiratory distress syndrome (ARDS) onset (severe non-severe...
Several studies have established the sortilin-related receptor gene (SORL1) as a susceptibility locus for Alzheimer's disease (AD). Single nucleotide polymorphisms of SORL1 reported in literature being associated with AD were investigated an Italian case-control data set, and their role risk factor conversion to was studied independent sample subjects diagnosed mild cognitive impairment (MCI) at baseline. rs641120, rs2070045, rs1010159 genotyped 734 (n = 338) MCI 181) healthy controls 215)....