A5064944598- Nerve injury and regeneration
- Prenatal Substance Exposure Effects
- Sarcoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Alcohol Consumption and Health Effects
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Neuroblastoma Research and Treatments
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Alcoholism and Thiamine Deficiency
- Regulation of Appetite and Obesity
- Head and Neck Cancer Studies
- Long-Term Effects of COVID-19
- Parasites and Host Interactions
- Neonatal and fetal brain pathology
- COVID-19 Clinical Research Studies
- Diet and metabolism studies
- Substance Abuse Treatment and Outcomes
- Olfactory and Sensory Function Studies
- Metabolism and Genetic Disorders
Institute of Cell Biology and Neurobiology
2016-2025
IMDEA Networks
2021-2025
Sapienza University of Rome
2018-2025
Fondazione IRCCS Istituto Nazionale dei Tumori
2023-2025
Ospedale Sandro Pertini
2024
National Research Council
2012-2024
Center for Excellence in Molecular Cell Science
2019-2024
Université Libre de Bruxelles
2024
Policlinico Umberto I
2020-2024
National Academies of Sciences, Engineering, and Medicine
2014-2020
Immunotherapy is a novel potential treatment for nicotine addiction. The aim of this study was to assess the safety and immunogenicity conjugate vaccine, NicVAX, its effects on smoking behavior. Smokers (N = 68) were recruited noncessation assigned 1 3 doses vaccine (50, 100, or 200 microg) placebo. They injected days 0, 28, 56, 182 monitored period 38 weeks. Results showed that safe well tolerated. Vaccine dose-related (P < .001), with highest dose eliciting antibody concentrations within...
The hypothalamic pituitary adrenal axis and dopamine have a key role in transition from alcohol social use to addiction. medial prefrontal cortex was shown modulate dopaminergic activity cortisol releasing factor (CRF) release extra-hypothalamic systems. recent advancements non-invasive neurostimulation technologies has enabled stimulation of deeper brain regions using H-coil transcranial magnetic (TMS) humans. This randomized double-blind placebo-controlled pilot study aims evaluate...
Early experiences affect brain function and behavior at adulthood. Being reared in a communal nest (CN), consisting of single where three mothers keep their pups together share care-giving from birth to weaning (postnatal day [PND] 25), provides an highly socially stimulating environment the developing pup. Communal characterizes natural ecologic niche many rodent species including mouse. At adulthood, CN mice, compared mice standard nesting laboratory condition (SN), show increase BDNF...
Ethanol (EtOH) exposure during pregnancy induces cognitive and physiological deficits in the offspring. However, role of paternal alcohol (PAE) on offspring EtOH sensitivity neurotrophins has not received much attention. The present study examined whether PAE may disrupt nerve growth factor (NGF) and/or brain-derived neurotrophic (BDNF) affect preference/rewarding properties male CD1 sire mice were chronically addicted for or administered with sucrose. Their offsprings when adult assessed...
In this study, we evaluated, in the mouse, effects of 20 mg/kg i.p. daily administration for 15 consecutive days a blend polyphenols, containing mostly oleuropein, extracted from olive leaves (Olea europaea) on brain nerve growth factor (NGF) and brain-derived neurotrophic (BDNF) expression their receptors, TrkA, TrkB p75. Polyphenols decreased levels reduced glutathione (GSH) increased NGF BDNF serum. brain, found hippocampus striatum but elevated olfactory lobes hypothalamus again...
COVID-19 (COronaVIrus Disease 19) is an infectious disease also known as acute respiratory syndrome caused by the SARS-CoV-2. Although in children and adolescents SARS-CoV-2 infection produces mostly mild or moderate symptoms, a certain percentage of recovered young people condition malaise, defined long-COVID-19, remains. To date, risk factors for development long-COVID-19 are not completely elucidated. Neurotrophins such NGF (Nerve Growth Factor) BDNF (Brain-Derived Neurotrophic to...