A5075795731- Hypothalamic control of reproductive hormones
- Nerve injury and regeneration
- Inflammatory Bowel Disease
- Vitamin C and Antioxidants Research
- Infant Development and Preterm Care
- Sperm and Testicular Function
- Long-Term Effects of COVID-19
- Reproductive Biology and Fertility
- Autoimmune and Inflammatory Disorders Research
- Ovarian cancer diagnosis and treatment
- Sexual Differentiation and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Heme Oxygenase-1 and Carbon Monoxide
- Blood Coagulation and Thrombosis Mechanisms
- Adrenal Hormones and Disorders
- Maternal and fetal healthcare
- Menstrual Health and Disorders
- Coenzyme Q10 studies and effects
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Neurogenesis and neuroplasticity mechanisms
- Antioxidant Activity and Oxidative Stress
- Testicular diseases and treatments
- Genetics and Neurodevelopmental Disorders
- S100 Proteins and Annexins
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2023
COVID-19 (COronaVIrus Disease 19) is an infectious disease also known as acute respiratory syndrome caused by the SARS-CoV-2. Although in children and adolescents SARS-CoV-2 infection produces mostly mild or moderate symptoms, a certain percentage of recovered young people condition malaise, defined long-COVID-19, remains. To date, risk factors for development long-COVID-19 are not completely elucidated. Neurotrophins such NGF (Nerve Growth Factor) BDNF (Brain-Derived Neurotrophic to...
Background: Oxidative stress, defined as an imbalance between reactive oxygen species and antioxidant defenses, plays a pivotal role in the pathogenesis of sex chromosome aneuploidies (SCAs), such Turner syndrome (TS) Klinefelter (KS). Pediatric patients with SCAs are particularly susceptible due to hormonal deficiencies, metabolic disturbances, systemic complications. Methods: A comprehensive literature search was conducted November 2024 using PubMed, Scopus, Web Science. Keywords included...
Fetal Alcohol Spectrum Disorders (FASD) are the manifestation of damage caused by alcohol consumption during pregnancy. Children with Syndrome (FAS), extreme FASD manifestation, show both facial dysmorphology and mental retardation. consumed gestational age prejudices brain development reducing, among others, synthesis release neurotrophic factors neuroinflammatory markers. drinking also induces oxidative stress.The present study aimed to investigate potential association between...
Klinefelter syndrome (KS) is a male genetic disease caused by the presence of an extra X chromosome, causing endocrine disorders mainly responsible for high rate infertility and metabolic in adulthood. Scientific research interested identifying new biomarkers that can be predictive or prognostic alterations strictly connected to KS. Lipocalin-2 (LCN-2, also known as NGAL) small protein initially identified within neutrophils related innate immunity. Serum LCN-2 estimation seems useful tool...
The prokineticin-2 (PROK2) is a small peptide belonging to the prokineticin family. In humans and rodents this chemokine primarily involved in control of central peripheral reproductive processes. Klinefelter's syndrome (KS) first cause male genetic infertility, due an extra X chromosome, which may occur with classical karyotype (47, XXY) or mosaic forms (46, XY/47, XXY). affected subjects, pubertal maturation usually begins at adequate chronological age, but when development almost...
Anemia is one of the most common extraintestinal manifestations pediatric inflammatory bowel disease (IBD). We aimed to evaluate prevalence anemia in children newly diagnosed with IBD and assess efficacy safety oral iron therapy over a 12-month follow-up period.This single-center, retrospective, observational cohort study included all at Pediatric Gastroenterology Unit Sapienza University Rome from May 2015 2019 presenting anemia. At baseline, demographic, clinical, laboratory data...
Intellectual disability is the impairment of cognitive, linguistic, motor and social skills that contribute to global level intelligence occurs in pediatric age, now comprises also term "mental retardation" used past describe same impairments under 5 years age. involves 3% general population, due a genetic cause including chromosome aberrations account for 3-28% intellectual disability. Between people with disabilities, disorders was identified as single gene disorder up 12%, multifactorial...
Puberty identifies the transition from childhood to adulthood. It normally lasts 3 5 years and begins 9 in males 8 females, although with differences related familiarity geographical origin. Precocious puberty is onset of signs pubertal development before age girls boys, it has an incidence 1/5000–1/10.000 F:M ratio ranging 3:1 20:1. Based on mechanism that triggers puberty, precocious can be classified as central, also known gonadotropin-dependent or true peripheral,...
Prenatal alcohol exposure causes a variety of impairments to the fetus called Fetal Alcohol Spectrum Disorders (FASD). Since it is very difficult identify women that consume during pregnancy, different methods have been studied evaluate exposure. Ethyl Glucuronide (EtG) and Fatty Acid Esters (FAEEs) are commonly used measure consumption in individuals at-risk for abuse, including pregnant women.
Abstract Background High-risk (HR) Crohn’s Disease (CD) is associated with high surgical and progression rates. Therefore, recent ESPGHAN guidelines (GL) suggest starting an early anti-TNFα treatment to modify the natural history of disease. The aim our study was evaluate rate in a population HR-CD paediatric patients treated up-front agents long-standing biologic therapy Methods This retrospective, observational, single-center conducted at Paediatric Gastroenterology, Hepatology, Endoscopy...
Splenogonadal fusion in female patients is seldom reported. We describe a 6-month-old girl who represents the youngest living with splenogonadal reported to date. The lesion was diagnosed as an incidental finding during screening abdominal ultrasonography performed for vulvar infantile hemangioma. A tail-like structure splenic echotexture connecting normally located spleen and left ovary detected better characterized by MRI. also reviewed pertinent literature on managing this usually...