A5045588732- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Hypothalamic control of reproductive hormones
- Testicular diseases and treatments
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Ovarian function and disorders
- Pharmacology and Obesity Treatment
- Estrogen and related hormone effects
- Respiratory Support and Mechanisms
- Urologic and reproductive health conditions
- Sexual function and dysfunction studies
- Ovarian cancer diagnosis and treatment
- Adrenal and Paraganglionic Tumors
- Thermal Regulation in Medicine
- Diet and metabolism studies
- Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Birth, Development, and Health
- Sex and Gender in Healthcare
- Renaissance and Early Modern Studies
- Trace Elements in Health
Sapienza University of Rome
2018-2025
Society for Academic Emergency Medicine
2024
Policlinico Umberto I
2018-2023
Bambino Gesù Children's Hospital
2023
University of L'Aquila
2022
Santobono Children's Hospital
2021
University of Molise
2021
Italian Society of Physiotherapy
2017
University of Naples Federico II
2016
High-grade aneuploidies of X and Y sex chromosomes (HGAs) are exceedingly rare complex conditions. We aimed to investigate the effect supernumerary (extra-Xs) on clinical, hormonal, metabolic, echocardiographic features patients with HGAs.
Testicular ultrasound (US) is routinely employed in the evaluation of reproductive and sexual function. However, its use for characteristics other than testicular volume hampered by a lack information on prognostic value findings, which to date have only been incorporated score proposed Lenz et al 1993.We sought explore whether US examination can predict quality spermatogenesis provide endocrine function.We retrospectively reviewed 6210 examinations, finally selecting examinations from 2230...
Klinefelter syndrome is the most common chromosomal disorder in males and cause of hypergonadotropic hypogonadism. We describe natural history testicular dysfunction patients with through integration clinical, hormonal, quantitative ultrasound data a life-course perspective.Prospective semilongitudinal study.We included 155 subjects 47,XXY karyotype (age range: 7 months-55 years) naïve to testosterone replacement therapy. Subjects were divided according pubertal stage age group (transition...
Abstract Purpose The role of osteocalcin (OCN) in pubertal development, male hypogonadism, and the effect testosterone (Te) replacement therapy (TRT) remains unclear. We aimed to investigate total OCN (tOCN) concentrations patients with Klinefelter syndrome (KS), a model adult hypergonadotropic hypogonadism. Methods This retrospective longitudinal study investigated 254 KS (47,XXY) between 2007 2021 at an academic referral center, categorized as (1) prepubertal, (2) pubertal, (3) adults. All...
Abstract Klinefelter Syndrome (KS) is caused by the presence of a supernumerary X-chromosome (conferring classical 47,XXY karyotype) and commonest sex chromosome abnormality in men. The clinical features described early characterisation syndrome include tall stature, small testes, hypogonadism, gynecomastia neurodevelopmental deficits. However, presents broad phenotypic spectrum that seems to be evolving, along with environmental general health changes. Although proportion men KS are...
Abstract Purpose Most patients with Turner Syndrome (TS) require Hormone Replacement Therapy (HRT). Androgen levels could be compromised due to both ovarian insufficiency and HRT. Despite this, the association between androgen deficiency, sexual health, body image perception remains underexplored in these patients. This study aimed assess hormone levels, function, women TS, categorized by karyotype HRT regimen. Methods A cross-sectional analysis of 29 TS was performed. Clinical, hormonal,...
It has been claimed that thyroid dysfunction contributes to the spectrum of Klinefelter syndrome (KS); however, studies are scarce.In a retrospective longitudinal study, we aimed at describing hypothalamic-pituitary-thyroid (HPT) axis and ultrasonographic (US) appearance in patients with KS throughout life span.A total 254 (25.9 ± 16.1 years) were classified according their pubertal gonadal status compared different groups non-KS age-matched individuals normal function, treated untreated...
Abstract Hemochromatosis (HC) is characterized by the progressive accumulation of iron in body, resulting organ damage. Endocrine complications are particularly common, especially when condition manifests childhood or adolescence, HC can adversely affect linear growth pubertal development, with significant repercussions on quality life even into adulthood. Therefore, a timely and accurate diagnosis these disorders mandatory, but sometimes complex for hematologists without endocrinological...
Vitamin B12 (or cobalamin) is an essential vitamin for DNA synthesis, fatty acid and protein metabolism as well other metabolic pathways fundamental to the integrity of cells tissues in humans. It derived from diet mostly stored liver. Its deficiency has been associated with derangements, i.e., obesity, glucose intolerance, increased lipogenesis dysfunction-associated steatotic liver disease (MASLD) steatohepatitis (MASH). However, data regard body weight across whole spectrum (from...
Abstract Context Experimental studies on Klinefelter syndrome (KS) reported increased intratesticular testosterone (T) levels coexisting with reduced circulating levels. Abnormalities in testicular microcirculation have been claimed; however, no investigated vivo blood flow dynamics humans KS. Objective To analyze the KS by contrast-enhanced ultrasonography (CEUS) and correlate vascular parameters endocrine function. Design Setting Prospective study. University setting. Patients Sixty-eight...
Background. This study, a randomized controlled trial, aims to demonstrate clinically significant improvement in subacute and chronic otitis media with effusion through the administration of hyaluronic acid associated hypertonic solution compared alone. The setting was an outpatient clinic 20 primary care pediatrician offices affiliated 3 Local Health Units (Azienda Sanitaria Locale) Naples. Materials Methods. study conducted for 6 months, from October 2014 end March 2015. saw participation...
Abstract Background Sellar/parasellar lesions have been studied in the adult and paediatric age range, but during transition their epidemiology, clinical manifestations, management treatment outcomes poorly investigated. Materials methods An Italian multicentre cohort study, which hospital records of patients with diagnosis sellar/parasellar young adulthood (15–25 years), were reviewed terms prevalence, hormonal features at diagnosis, where available. Both pituitary neuroendocrine tumours...
Puberty identifies the transition from childhood to adulthood. It normally lasts 3 5 years and begins 9 in males 8 females, although with differences related familiarity geographical origin. Precocious puberty is onset of signs pubertal development before age girls boys, it has an incidence 1/5000–1/10.000 F:M ratio ranging 3:1 20:1. Based on mechanism that triggers puberty, precocious can be classified as central, also known gonadotropin-dependent or true peripheral,...