A5007953435- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- HIV Research and Treatment
- Amyotrophic Lateral Sclerosis Research
- Mass Spectrometry Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Advanced Proteomics Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV-related health complications and treatments
- Thyroid Cancer Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- MicroRNA in disease regulation
- Metabolomics and Mass Spectrometry Studies
- Organic and Inorganic Chemical Reactions
- Cytomegalovirus and herpesvirus research
- Genetics and Neurodevelopmental Disorders
- Folate and B Vitamins Research
- Molecular Biology Techniques and Applications
- Chemical Reaction Mechanisms
- Infectious Encephalopathies and Encephalitis
- Neurological diseases and metabolism
- Frailty in Older Adults
- Nutritional Studies and Diet
- RNA Research and Splicing
- Neurogenetic and Muscular Disorders Research
University of Milan
2011-2023
University of Milano-Bicocca
2019-2022
Luigi Sacco Hospital
2008-2017
Karolinska Institutet
2016
Stockholm University
2016
Casa di Cura Columbus
2013
This multicenter study examined (18)F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and with Lewy bodies (DLB) from normal aging each other relation disease-specific patterns to mild cognitive impairment (MCI).We scans 548 subjects, including 110 healthy elderly individuals ("normals" or NLs), 114 MCI, 199 AD, 98 FTD, 27 DLB patients, collected at 7 participating centers. Individual were Z scored using automated voxel-based...
Epidemiological data show a higher prevalence of late-onset Alzheimer's disease (AD) in women. The estrogenic deficiency the post-menopausal period is suspected to be cause gender-related risk disease, but studies on therapy and occurrence AD were not consistent sometimes contradicting. aim this study investigate whether exposure endogenous estrogens associated with lower dementia or not. Two hundred four patients 201 control women considered. By interviews, we evaluated different variables,...
Weight loss is common in people with Alzheimer's disease (AD) and it could be a marker of impending AD Mild Cognitive Impairment (MCI) improve prognostic accuracy, if accelerated progression to would shown.To assess weight as predictor dementia MCI.One hundred twenty-five subjects MCI (age 73.8 ± 7.1 years) were followed for an average 4 years. Two measurements carried out at minimum time interval one year. Dementia was defined according DSM-IV criteria NINCDS-ADRDA criteria. ≥4% decrease...
Leisure activities, particularly exercise, play a protective role against dementia in healthy people, but it is unknown if this effect could be generalized to subjects with mild cognitive impairment (MCI).To investigate the influence of leisure activities on risk progression MCI dementia.176 attending memory clinic underwent standardized lifestyle questionnaire between October 2007 and May 2010. Social, cognitive, physical scores were derived based assiduity interpersonal contacts frequency...
Altered gene expression occurs in central nervous system disorders, including Alzheimer's disease (AD). Transcription factor Sp1 (specificity protein 1) can regulate the of several AD-related proteins, amyloid-β precursor
Mass spectrometry imaging (MSI) is an emerging technology that capable of mapping various biomolecules within their native spatial context, and performing multiomics on formalin-fixed paraffin-embedded (FFPE) tissues may further increase the molecular characterization pathological states. Here we present a novel workflow which enables sequential MSI lipids, N-glycans, tryptic peptides single FFPE tissue section highlight enhanced offered by combining multiple omics data sets. In murine brain...
Mutations in the progranulin gene (GRN), causative for Frontotemporal Lobar Degeneration with ubiquitin-immunoreactive neuronal inclusions (FTLD-U), could also be associated Alzheimer's disease (AD). The influence of GRN genetic variability on susceptibility to AD and expression levels a series neuropathologically-confirmed patients as well peripheral mononuclear cells (PBMC) isolated from cerebrospinal fluid (CSF) was investigated. An association study rs9897526 rs5848 carried out an...
An association study of heterogeneous nuclear ribonucleoprotein (hnRNP)-A1 was carried out in a population 274 patients with frontotemporal lobar degeneration (FTLD) and 287 Alzheimer disease (AD) as compared 344 age- gender-matched controls. In addition, we evaluated expression levels hnRNP-A1 its regulatory microRNA (miR)-590-3p blood cells from A statistically significant increased frequency the rs7967622 C/C genotype observed FTLD, but not AD, to controls (23.0 versus 15.4%; p = 0.022,...
To examine the relationship between body mass index (BMI) and progression to dementia Alzheimer's disease (AD) in mild cognitive impairment (MCI).Two hundred twenty-eight MCI subjects (mean age 74.04 ± 6.94 years; 57% female) from a memory clinic were followed for 2.40 1.58 years. Baseline height weight used calculate BMI. The main outcome was (DSM-IV criteria) AD (NINCDS-ADRDA criteria). Cox proportional hazard models assess longitudinal association of BMI with AD, adjusting comprehensive...
Formalin-fixed paraffin-embedded (FFPE) tissue represents the primary source of clinical and is routinely used in MALDI-MSI studies. However, it not particularly suitable for lipidomics imaging given that many species are depleted during processing. Irrespective, a number solvent-resistant lipids remain, but their extraction may be hindered by cross-link between proteins. Therefore, an antigen retrieval step could enable greater provide information complementary to which can obtained from...
Background and purpose: Progranulin ( PGRN ) expression is increased in activated microglia Alzheimer's disease (AD) brain, suggesting a potential role this pathology. Methods: A mutation scanning of exons flanking regions was carried out 120 patients with sporadic frontotemporal lobar degeneration 145 AD. Results: Amongst variants not yet deposited, novel allelic variant identified Exon 1 (g100169 G > ). It leads to an amino acidic change (p.Gly35Arg) observed patient late onset In...
Abstract Background Human sirtuins are a current hotspot for research in neurodegenerative disorders, including Alzheimer's disease (AD). This study investigated whether genetic variants two members of the sirtuin family, SIRT2 and SIRT3 , affected AD susceptibility. Methods A case–control was performed, comprising 534 probable cases 638 nondemented control subjects from north Italy Canton Ticino, Switzerland (discovery population). The focused on rs10410544, rs4980329, rs536715 single...
To investigate the contribution of vascular risk factors (VRFs), diseases (VDs) and white matter lesions (WMLs) to progression mild cognitive impairment (MCI) dementia Alzheimer's disease (AD).Two hundred forty-five consecutive subjects with MCI (age 74.09 ± 6.92 years) were followed for an average 2.4 years. The Hachinski Ischemic Score Framingham Stroke Risk Profile used summarize VRFs VDs. WMLs graded using Age-Related White Matter Changes Scale.One twenty-nine (52.6%) out 245 at...
Dementia is a known predictor of mortality, but little about disease duration. We therefore aimed to investigate the impact dementia on survival by estimating years lived with disease, in total and different severity stages, comparing other major chronic disorders such as cancer cardiovascular (CVD). During 7.4-year follow-up Kungsholmen project, 371 incident cases 1,307 dementia-free persons, aged 75+ at baseline, were clinically diagnosed (DSM-III-R criteria). Diagnoses CVD obtained from...
The prognostic value of mild cognitive impairment (MCI) is being questioned, with some MCI subjects reverting to normal cognition (NC). reversion rate varies mostly depending on the study design, setting, and both NC definitions. Previous studies have focused profile who revert NC, but role comorbidities has not been entirely investigated. We aimed evaluate proportion in a memory clinic context, focusing comorbidities. Between 2004 2013, 374 were recruited. During mean time 32 ± 25.5 months,...
Alzheimer's disease (AD) is a neurodegenerative disorder often treated with donepezil, an acetylcholinesterase inhibitor. Response to donepezil variable, probably based on patients' genetic background in metabolizing enzymes, including c
The present study applies for the first time as Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) on real thyroid Fine Needle Aspirations (FNAs) to test its possible complementary role in routine cytology diagnosis of nodules. primary aim is evaluate potential employment MALDI-MSI cytopathology, using challenging samples such needle washes. Firstly, we designed a statistical model based analysis Regions Interest (ROIs), according morphological triage...