A5073478237- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Health disparities and outcomes
- Folate and B Vitamins Research
- Long-Term Effects of COVID-19
- Amyotrophic Lateral Sclerosis Research
- Cerebrovascular and genetic disorders
- Intensive Care Unit Cognitive Disorders
- S100 Proteins and Annexins
- Health Systems, Economic Evaluations, Quality of Life
- Cholinesterase and Neurodegenerative Diseases
- Glycogen Storage Diseases and Myoclonus
- Mitochondrial Function and Pathology
- Healthcare Systems and Public Health
- Advanced Neuroimaging Techniques and Applications
- Tryptophan and brain disorders
- Chronic Disease Management Strategies
- COVID-19 Clinical Research Studies
- Health, Environment, Cognitive Aging
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
Fondazione Golgi Cenci
2016-2025
UNSW Sydney
2024
Philippine General Hospital
2022
Mario Negri Institute for Pharmacological Research
2012
Istituti di Ricovero e Cura a Carattere Scientifico
2012
Background Changes in criteria and differences populations studied methodology have produced a wide range of prevalence estimates for mild cognitive impairment (MCI). Methods Uniform were applied to harmonized data from 11 studies USA, Europe, Asia Australia, MCI determined using three separate definitions impairment. Results The published was 5.0%–36.7%. This reduced with all definitions: performance the bottom 6.681% (3.2%–10.8%); Clinical Dementia Rating 0.5 (1.8%–14.9%); Mini-Mental...
Delirium may be one of the presenting symptoms COVID-19, complicating diagnosis and care elderly patients with dementia. We aim to identify prevalence prognostic significance delirium as sole onset manifestation COVID-19.This is a retrospective single-centre study based on review medical charts, conducted during outbreak peak (March 27-April 18, 2020) in Lombard dementia facility, including 59 subjects laboratory-confirmed COVID-19.Of residents, 57 (96⋅6%) tested positive (mean age: 82⋅8;...
The actual role of SARS-CoV-2 in brain damage remains controversial due to lack matched controls. We aim highlight what extent is neuropathology determined by or pre-existing conditions. Findings 9 Coronavirus disease 2019 (COVID-19) cases and 6 non-COVID controls (mean age 79 y/o) were compared. Brains analyzed through immunohistochemistry detect SARS-CoV-2, lymphocytes, astrocytes, endothelium, microglia. A semi-quantitative scoring was applied grade microglial activation. Thal-Braak...
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence not well known. We aimed to use uniform criteria better estimate SCD across international cohorts. Methods combined individual participant data 16 cohorts from 15 countries (members of the COSMIC consortium) used qualitative quantitative (Item Response Theory/IRT) harmonization techniques prevalence. Results The sample comprised 39,387...
SARS-Cov-2 infection is frequently associated with Nervous System manifestations. However, it not clear how SARS-CoV-2 can cause neurological dysfunctions and which molecular processes are affected in the brain. In this work, we examined frontal cortex tissue of patients who died COVID-19 for presence SARS-CoV-2, comparing qRT-PCR ddPCR. We also investigated transcriptomic profile from matched controls by RNA-seq analysis to characterize transcriptional signature. Our data showed that could...
Abstract Background Preventing dementia onset is one of the global public health priorities: around 35% cases could be attributable to modifiable risk factors. These estimates relied on secondary data and did not consider concurrent effect non-modifiable factors death. Here, we aimed estimate potential reduction incidence due elimination, controlling for competing Methods Participants from InveCe.Ab population-based prospective cohort (Abbiategrasso, Italy) without a baseline diagnosis...
Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life. A growing consensus supports contribution chronic inflammation immune system alterations frailty, however clear role such remains be elucidated. Furthermore, pro- anti-inflammatory cytokines together with other signaling molecules might spread from activated cells adjacent ones through extracellular vesicles (EVs), which have also in cellular...
Developed countries are experiencing an unprecedented increase in life expectancy that is accompanied by a tremendous rise the number of people with dementia. The purpose this paper to report on study design and methodology Italian population-based brain aging dementia elderly. This multi-domain structured two phases. Our goal gather sufficient data estimate prevalence (phase I: cross-sectional study), incidence progression its subtypes as well cognitive impairment II: follow-up study)...
Abstract Aims Perilipins are conserved proteins that decorate intracellular lipid droplets and essential for metabolism. To date, there is limited knowledge on their expression in human brain or involvement aging neurodegeneration. The aim of this study was to characterise the levels perilipins (Plin1–Plin5) different cerebral areas from subjects age, with without signs Methods We performed real‐time RT‐PCR, western blotting, immunohistochemistry confocal microscopy analyses autoptic samples...
Abstract Background Human sirtuins are a current hotspot for research in neurodegenerative disorders, including Alzheimer's disease (AD). This study investigated whether genetic variants two members of the sirtuin family, SIRT2 and SIRT3 , affected AD susceptibility. Methods A case–control was performed, comprising 534 probable cases 638 nondemented control subjects from north Italy Canton Ticino, Switzerland (discovery population). The focused on rs10410544, rs4980329, rs536715 single...
Background and Purpose Dehydroepiandrosterone ( DHEA ) is thought to be an anti‐glucocorticoid hormone known fully functional in young people but deficient aged humans. Our previous data suggest that not only counteracts the effect of cortisol on RACK1 expression, a protein required both for correct functioning immune cells PKC ‐dependent pathway activation, also modulates inhibitory LPS ‐induced cytokine production. The purpose this study was investigate splicing mechanism human...
Abstract We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, vascular risk factors. Participants 19,225 individuals aged 54–103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging 1.2 10.7 years. Two-step individual participant data meta-analysis was used pool results of study-wise analyses predicting memory general decline one or...
Abstract The central nervous system (CNS) is surrounded by three membranes called meninges. Specialised fibroblasts, originating from the mesoderm and neural crest, primarily populate meninges serve as a binding agent. Our goal was to compare fibroblasts skin obtained same human‐aged donors, exploring their molecular cellular characteristics related CNS functions. We isolated meningeal (MFs) brain donors (SFs) subjects. A functional analysis performed measuring cell appearance, metabolic...
Poststroke cognitive impairment is common, but the trajectory following a first stroke, relative to prestroke function, remains unclear.
Estimates of depressive disorders in the elderly vary depending on how cases are defined. We estimated prevalence subthreshold depression (SD) and clinically significant (D) a population 70-74-year-olds. also looked for associations with sociodemographic factors perceptions self. Participants underwent multidimensional assessment (social, medical, neuropsychological). The SD was 15.71% (95% CI: 13.70-17.72), while that D 5.58% 4.31-6.85). Multinomial logistic regression analysis revealed...