Abstract Objective: Sex steroid hormones are thought to contribute the growth, differentiation, and progression of prostate cancer. We investigated plasma levels sex length androgen receptor gene CAG repeat in relation incident cancer diagnosed prostate-specific antigen (PSA) era. Methods: Using a nested case-control design, we included 460 cases after providing blood specimen 1993 but before February 1998 among men Health Professionals Follow-up Study. Controls were age-matched without who...

Learning Objectives Review the epidemiology and clinical consequences of arsenic exposure. Explain relationships found in this case-control study among cumulative exposure, primary secondary methylation, gender, skin cancer. Understand how widely—if at all—the findings may be generalized to populations other than Taiwanese. Arsenic is a known carcinogen, but data are especially lacking on health effects low-level significance methylation ability. We conducted (76 cases 224 controls from 1996...

The aging rate in Taiwan is the second highest world. As population ages quickly, prevalence of dementia increases rapidly. There are some studies that have explored association between air pollution and cognitive decline, but has not been directly evaluated.This was a case-control study comprising 249 Alzheimer's disease (AD) patients, 125 vascular (VaD) 497 controls from three teaching hospitals northern 2007 to 2010. Data particulate matter <10 μm diameter (PM10) ozone were obtained...

Abstract Chronic inflammation has been hypothesized to be a risk factor for prostate cancer. The Toll-like receptor 4 (TLR4) presents the bacterial lipopolysaccharide (LPS), which interacts with ligand-binding protein and CD14 (LPS receptor) activates expression of inflammatory genes through nuclear factor-κB mitogen-activated kinase signaling. A previous case-control study found modest association polymorphism in TLR4 gene [11381G/C, GG versus GC/CC: odds ratio (OR), 1.26] We assessed if...

ABSTRACT Osteoporosis is related to the alteration of specific circulating metabolites. However, previous studies on only a few metabolites inadequately explain pathogenesis this complex syndrome. To date, no study has metabolome bone mineral density (BMD), which would provide an overview metabolism status and may be useful in clinical practice. This cross-sectional involved 601 healthy Taiwanese women aged 40 55 years recruited from MJ Health Management Institution between 2009 2010....

Nursing students have particularly experienced stressful lives during nursing education. This cross-sectional study aimed to investigate depressive symptoms and related factors in junior college students. A total of 625 from a Taiwan were assessed by Pittsburgh Sleep Quality Index, Adolescent Depression Inventory, Situational Anxiety Scale the Taiwanese-Chinese version Stress Students Scale. The results showed that (1) prevalence among was 32.6%; (2) are significantly grade point average,...

This study aimed to identify lifestyle factors associated with cognitive change and explore whether the effect of varies by socioeconomic status (SES). Participants aged 65 years older were recruited from elderly health checkup programs 2011 2013 in Taiwan. Neuropsychological tests, including tests global cognition, logical memory, executive function, verbal fluency attention, administered at baseline (N = 603) 2 later 509). After literature review, 9 3 SES indicators chosen their effects on...

This study aimed to explore the links of handgrip strength and asymmetry with cognitive impairment. was a seven-year prospective cohort study. We used data from wave 3 (2015-2017) 5 (2019-2022) ongoing Taiwan Initiative Geriatric Epidemiological Research (TIGER), as baseline (n = 446). The included community-dwelling participants aged 65 years or older. Handgrip measured, abnormalities were determined based on weakness asymmetry. categorized into three groups at ratio (left strength/right...

Coffee and tea consumption has been linked to dementia. However, it remained unknown how sex vascular risk factors modify the association. We aimed investigate association of coffee with dementia whether comorbidities modified included 278 elderly patients Alzheimer's disease (AD) 102 (VaD) from three hospitals; controls (N = 468) were recruited during same period. collected frequency amount presence comorbidities. The multinomial logistic regression model was utilized evaluate dementia,...

ObjectiveWe investigated whether primary and secondary arsenic methylation ratios were associated with skin lesions GSTT1, GSTP1, GSTM1 polymorphisms modify these relationships.MethodsA case–control study of 600 cases controls that frequency matched on age sex was conducted in Pabna, Bangladesh, 2001–2002. Individual well water, urine, blood samples collected. Water concentration determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary speciation high performance...

How indoor air quality affects the temporal associations of long-term exposure to low-level pollutants with cognition remains unclear.This cohort study (2011-2019) included 517 non-demented older adults at baseline four repeated cognitive assessments. The time-varying PM2.5, PM10, NO2, SO2, CO, and O3 was estimated for each participant from 1994 2019. Indoor determined by ventilation status daily time. Generalized linear mixed models were used analyze association pollutants, quality,...

Objectives: To describe the occurrence and management of suspected pneumonia in end‐stage dementia to identify factors associated with aggressiveness antibiotic treatment. Design: Retrospective cohort study. Setting: A 675‐bed long‐term‐care facility Boston, Massachusetts. Participants: Two hundred forty subjects aged 65 older who died advanced between January 2001 December 2003. Subjects had during last 6 months life were identified. Measurements: Independent variables included subject...

Abstract BACKGROUND A family history of prostate cancer (PCa) or breast (BCa) has been associated with the risk PCa, but risks were inconsistent in terms affected members, and data PSA era are limited. METHODS This study included a subcohort Health Professionals Follow‐Up Study composed highly screened population from 1986 to 2004 3,695 PCa cases identified. Questionnaires food frequency questionnaire administered every other 4 years, respectively. Family BCa was ascertained 1990, 1992,...

Interleukin 6 (IL-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in Alzheimer's disease (AD) brain. However, previous studies relating IL-6 genetic polymorphisms AD included few unrepresentative single nucleotide (SNPs) results were inconsistent.

Significant differences exist between eastern and western diets, the way in which Chinese dietary intake relates to specific cognitive domains remains unclear. We aimed assess association patterns (DPs) decline elderly.Participants were recruited from elderly health checkup program of a teaching hospital Taipei, Taiwan.A total 475 elders (age ≥65) included this prospective cohort study.The outcome comprised global domain-specific cognition baseline (2011-2013) follow-up (2013-2015). Dietary...

Objectives: Vegetarian diets have been shown to improve insulin resistance and reduce body weight, but the effects on nonalcoholic fatty liver require further confirmation. We aim investigate association between vegetarian diets, major food groups, liver, compare degree of fibrosis vegetarians nonvegetarians in those with liver. Materials Methods: analyzed cross-sectional data from Tzu Chi Health Study which included 2127 1273 who did not smoke or habitually drink alcohol had no hepatitis B...