A5090980742- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Sleep and Wakefulness Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Neurological Disease Mechanisms and Treatments
- Crystallography and molecular interactions
- Blood Pressure and Hypertension Studies
- Enzyme Structure and Function
- Nutritional Studies and Diet
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
- Endoplasmic Reticulum Stress and Disease
- Treatment of Major Depression
- GABA and Rice Research
- Vitamin C and Antioxidants Research
- Frailty in Older Adults
- EEG and Brain-Computer Interfaces
- Schizophrenia research and treatment
Kangdong Sacred Heart Hospital
2019-2024
Hallym University
1989-2024
Dr Youth Clinic
2023-2024
Seoul National University Bundang Hospital
2017-2021
Seoul National University
2007-2020
Universidad de Zaragoza
2020
National University College
2019
New Generation University College
2019
Weatherford College
2019
Korea Advanced Institute of Science and Technology
2019
To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies.Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild impairment [MCI]). At baseline 4-year follow-up assessments, sleep-related parameters (midsleep time, duration, latency, subjective quality, efficiency, daytime dysfunction) status measured using the Pittsburgh Sleep Quality Index Consortium to Establish...
Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from Health Industry Development Institute investigate epidemiology, biopsychosocial risk factors, outcomes dementia-related conditions.The KLOSCAD first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled...
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence not well known. We aimed to use uniform criteria better estimate SCD across international cohorts. Methods combined individual participant data 16 cohorts from 15 countries (members of the COSMIC consortium) used qualitative quantitative (Item Response Theory/IRT) harmonization techniques prevalence. Results The sample comprised 39,387...
Abstract Although light flickering at 40 Hz reduced Alzheimer’s disease (AD) pathologies in mice by entraining gamma waves, it failed to reduce cerebral amyloid burden a study on six patients with AD or mild cognitive impairment. We investigated the optimal color, intensity, and frequency of stimulus for waves young adults. compared event-related synchronization (ERS) values entrained between four different colors (white, red, green, blue) first experiment luminance intensities second...
<b><i>Background:</i></b> The aim of this study was to investigate the association gait speed and variability, an index how much parameters, such as step time, fluctuate step-to-step, with risk cognitive decline in cognitively normal elderly individuals. While high variability is emerging early indicator dementing illnesses, there little research on whether predicts who have no evidence impairment. <b><i>Methods:</i></b> In 4-year prospective...
Abstract Background There are growing concerns about the impact of COVID-19 pandemic on mental health older adults. We examined effect risk depression in Methods analyzed data from prospective cohort study Korean adults, which has been followed every 2 years. Among 2308 participants who completed both third and fourth follow-up assessments, 58.4% their before outbreak rest it during pandemic. conducted face-to-face diagnostic interviews using Mini International Neuropsychiatric Interview...
Abstract We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, vascular risk factors. Participants 19,225 individuals aged 54–103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging 1.2 10.7 years. Two-step individual participant data meta-analysis was used pool results of study-wise analyses predicting memory general decline one or...
Background: Although tooth loss is known to increase the risk of cognitive impairment and dementia, few studies have investigated association between functional teeth including rehabilitated lost function Objective: We associations numbers occlusal units with in late life. Methods: The current study was conducted as a part Korean Longitudinal Study on Cognitive Aging Dementia (KLOSCAD), community-based elderly cohort study. analyzed 411 participants who agreed additional dental exam....
Both hypertension and hypotension increase cerebral white matter hyperintensities. However, the effects of in individuals with treated are unknown. We analyzed association low blood pressure location amount hyperintensities between elderly controlled those without hypertension.We enrolled 505 community-dwelling, cognitively normal from participants Korean Longitudinal Study on Cognitive Aging Dementia. measured three times a sitting position using mercury sphygmomanometer defined systolic...
Brain volume is influenced by several factors that can change throughout the day. In addition, most of these are sleep quality. This study investigated diurnal variation in brain and its relation to overnight
Previous studies have shown that coffee consumption may suppress the production of melatonin in pinealocytes through competitive inhibition adenosine A2 receptors by caffeine. We investigated impact lifetime on pineal gland volume and resulting effects sleep quality. enrolled 162 cognitively normal elderly individuals among participants Korean Longitudinal Study Cognitive Aging Dementia. evaluated patterns amounts using a study-specific standardized interview assessed quality Pittsburgh...
We investigated the effects of lifetime cumulative ginseng intake on cognitive function in a community-dwelling population-based prospective cohort Korean elders. Community-dwelling elders (N = 6422; mean age 70.2 ± 6.9 years, education 8.0 5.3 female 56.8%) from Longitudinal Study Cognitive Aging and Dementia were included. Among them, 3918 participants (61.0%) completed 2-year 4-year follow-up evaluations. Subjects categorized according to at baseline evaluation; no use group, low (< 5...
Abstract Background Despite strong evidence that emotional support has a protective effect on cognitive decline, the neural basis for how an individual’s is associated with cognition unknown. We investigated if hippocampus mediates relationship between and in older adults. Method Four hundred ten nondemented Korean adults were classified into two groups according to their Medical Outcomes Study–Social Support Survey scores: poor (score ≤ 25th percentile of entire sample) normal &gt;...
Abstract Objectives Delirium is highly prevalent in patients with advanced cancer. This study aimed to investigate delirium rates and potential associated factors such as mortality admitted an acute palliative care unit (APCU). Our second aim was validate the Korean version of Memorial Assessment Scale (K‐MDAS). Methods A total 102 cancer, who were APCU, assessed. Demographic data collected alongside clinical diagnosis, Eastern Cooperative Oncology Group (ECOG) performance status, symptoms...
Prospective studies concerning sleep architecture and cognitive function have focused on individual measures per se, without considering the complementary role of non-REM (NREM) REM sleep. We explored association between NREM/REM cycle-related decline. Community-dwelling elderly people in Korea from Korean Longitudinal Study Cognitive Aging Dementia were enrolled. They cognitively normal underwent overnight polysomnography at baseline. A cycle is a sequence NREM sleep, uninterrupted by...
Despite its significance as a contributing factor for late-life dementia risk, illiteracy is frequently underappreciated in the management of dementia. In this study, we estimated proportion cases attributable to using population fraction (PAF), and calculated what extent monetary cost could be saved future by reducing from South Korean, Latin American, Asian/Middle Eastern, African populations. We collected necessary data 2011 United Nations Human Development Report prevalence studies...
We investigated the impact of depressed mood (dysphoria) and loss interest or pleasure (anhedonia)on risk dementia in cognitively-normal elderly individuals.This study included 2,685 individuals who completed baseline 4-year follow-up assessments Korean Longitudinal Study on Cognitive Aging Dementia. ascertained presence dysphoria anhedonia using Mini International Neuropsychiatric Inventory. defined subjective cognitive decline as complaints without objective impairments. analyzed...
In many high-income Western countries, the prevalence of dementia had been reduced over past decades.We investigated whether all-cause dementia, Alzheimer's disease, vascular and mild cognitive impairment (MCI) changed in Korea from 2008 to 2017.Nationwide Survey on Dementia Epidemiology (NaSDEK) 2017 was conducted representative elderly populations that were randomly sampled across South Korea. Both surveys employed a two-stage design (screening diagnostic phases) diagnosed MCI according...
Hypertension is associated with white matter hyperintensity (WMH) and cognitive impairment. Further, WMH impairment including executive, attention visuospatial functions. The aim of this study was to investigate the effects controlled hypertension (cHT) previously developed concept, 'WMH age' on function mediating role in effect cHT impairment.We enrolled 855 Koreans without dementia aged 60 years or older, 326 whom completed 2-year follow-up assessment. We measured their blood pressure...