A5012119130- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Health and Wellbeing Research
- Sleep and related disorders
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Peripheral Artery Disease Management
- Chronic Disease Management Strategies
- Diverse Approaches in Healthcare and Education Studies
- Schizophrenia research and treatment
- Frailty in Older Adults
- Pregnancy and preeclampsia studies
- Sleep and Wakefulness Research
- Cardiovascular Health and Disease Prevention
- Neurological Disease Mechanisms and Treatments
- Health and Well-being Studies
- Folate and B Vitamins Research
- Family Caregiving in Mental Illness
- Intergenerational Family Dynamics and Caregiving
- Older Adults Driving Studies
- Thyroid Disorders and Treatments
Konkuk University
2015-2024
Konkuk University Medical Center
2018-2024
Kangwon National University
2024
Kangwon National University Hospital
2021
Seoul National University Hospital
2017-2021
Seoul National University Bundang Hospital
2018-2021
Wonju Severance Christian Hospital
2021
Yonsei University
2021
Dongguk University
2021
Inje University Busan Paik Hospital
2017
Objective We developed a Korean version of Mini-Mental Status Examination (MMSE) optimized for screening dementia (MMSE-DS) and its' short form (SMMSE-DS). Methods constructed the MMSE-DS using items two current versions MMSE then construct SMMSE-DS consisted 13 from based on diagnostic accuracy individual dementia. investigated reliability validity 1,555 subjects (1,222 nondemented controls, 333 patients). compared with that three full MMSE, examined age- education-specific optimal cutoff...
We investigated the prevalence of dementia and mild cognitive impairment (MCI) factors associate with risk from a representative nationwide sample Korean elders. 8,199 randomly-sampled Koreans aged 65 years or older were invited to participate in Phase I screening assessment using Mini-Mental State Examination by door-to-door home visit, 6,141 subjects (response rate = 74.9%) responded. Among them, 2,336 II diagnostic for MCI, 1,673 responded 71.6%). Diagnostic assessments administered...
To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies.Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild impairment [MCI]). At baseline 4-year follow-up assessments, sleep-related parameters (midsleep time, duration, latency, subjective quality, efficiency, daytime dysfunction) status measured using the Pittsburgh Sleep Quality Index Consortium to Establish...
Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from Health Industry Development Institute investigate epidemiology, biopsychosocial risk factors, outcomes dementia-related conditions.The KLOSCAD first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled...
<h3>Objective</h3> To investigate the effects of completed pregnancy with childbirth and incomplete without on late-life cognition risk Alzheimer disease (AD) in women. <h3>Methods</h3> Using pooled data 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively associations risks mild cognitive impairment AD. For dementia, also covariance Mini-Mental State Examination (MMSE) score. <h3>Results</h3> Grand multiparous who...
Background:Mild cognitive impairment (MCI) is a state that lies on the continuum between normal aging and dementia, prevalence of MCI higher than dementia. However, risk for mortality people with has been far less studied po pulation attributable percent (PAR%) death to not estimated yet. Objective:To investigate impact cause in elderly, estimate PAR% deaths MCI. Methods:Data came from 7,315 elderly subjects aged ≥60 years without dementia two cohort studies diagnostic assessments at...
Abstract Background Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, association dementia women has rarely been studied. Methods We harmonized and pooled baseline data from 11 population-based cohorts countries over 3 continents, including 14,792 aged 60 years or older. investigated between parity using logistic regression models that adjusted age, educational level, hypertension,...
Abstract Aims & Objectives There have been no studies about the relationship between cerebellar volume and various psychological factors for normal subjects. This study analyzed of adults in third decade life (20-29 years) factors. Methods The 118 subjects (mean age, 23 ± 2.6 years), including 58 males 24 2.8 60 females 21.9 2.1 was measured using magnetic resonance imaging (MRI). following tests were performed on all subjects: Symptom Checklist-90-R (SCL-90-R), Component Type A...
This article investigates late-onset cognitive impairment using neuroimaging and genetics biomarkers for Alzheimer's Disease Neuroimaging Initiative (ADNI) participants. Eight-hundred eight ADNI subjects were identified divided into three groups: 200 with disease (AD), 383 mild (MCI), 225 asymptomatic normal controls (NC). Their structural magnetic resonance imaging (MRI) data parcellated BrainParser, the 80 most important extracted global shape analysis Pipeline workflow. Using Plink via...
Abstract Aims To investigate the association between parity and risk of incident dementia in women. Methods We pooled baseline follow-up data for community-dwelling women aged 60 or older from six population-based, prospective cohort studies four European two Asian countries. investigated using Cox proportional hazards regression models adjusted age, educational level, hypertension, diabetes mellitus cohort, with additional analysis by subtype (Alzheimer (AD) non-Alzheimer (NAD)). Results Of...
To investigate the effects of single sensory impairment (SSI; visual or auditory) dual (DSI; and on dementia longitudinal changes neuropsychological test scores.In this nationwide, prospective, community-based elderly cohort study, KLOSCAD (the Korean Longitudinal Study Cognitive Aging Dementia), 6,520 individuals (58-101 years) representing general population were included. We defined auditory via self-report questionnaire: 932 had normal function, 2,957 an SSI, 2,631 a DSI. Demographic...
Abstract Background There are growing concerns about the impact of COVID-19 pandemic on mental health older adults. We examined effect risk depression in Methods analyzed data from prospective cohort study Korean adults, which has been followed every 2 years. Among 2308 participants who completed both third and fourth follow-up assessments, 58.4% their before outbreak rest it during pandemic. conducted face-to-face diagnostic interviews using Mini International Neuropsychiatric Interview...
This study was conducted to confirm the results of authors' previous research on schizophrenia manifesting high serum homocysteine and low folate levels. is anchored a theory that concentration affects by virtue neurotoxic mechanism, report some patients with levels benefited from ingestion.The homocysteine, folate, vitamin B(12) 236 normal-control-group subjects 234 who met diagnostic criteria based DSM-IV-TR were compared. The measured via fluorescence polarization immunoassay, determined...
<h3>Objectives</h3> To clarify the relationships between sleep-wake cycle and cerebral β-amyloid (Aβ) deposition in cognitively normal (CN) older adults, focusing primarily on moderating effects of <i>APOE</i> ε4 allele. <h3>Methods</h3> The present study included 133 CN adults who participated Korean Brain Aging Study for Early Diagnosis & Prediction Alzheimer9s Disease cohort. All participants underwent [<sup>11</sup>C] Pittsburgh compound B-PET imaging to quantify Aβ brain blood...
Many contemporary neuroscientific investigations face significant challenges in terms of data management, computational processing, mining and results interpretation. These four pillars define the core infrastructure necessary to plan, organize, orchestrate, validate disseminate novel scientific methods, resources translational healthcare findings. Data management includes protocols for acquisition, archival, query, transfer, retrieval aggregation. Computational processing involves software,...
The aim of this study was to examine the change in hippocampal volume and shape early-onset mild cognitive impairment (EO-MCI) associated with APOE ε4 carrier state.This had 50 subjects aged 55-63 years, all whom were diagnosed MCI at baseline via Korean version Consortium Establish a Registry for Alzheimer's Disease Assessment Packet. EO-MCI patients divided into continued (MCIcont) disease (AD) converted (ADconv) groups 2 years later. measured subjects. local analysis (LSA) used conduct...
<h3>Importance</h3> Although couples could share many risk factors of cognitive disorders in their lifetime, whether shared mediate the has rarely been investigated. <h3>Objective</h3> To identify decline within and investigate mediating roles functions couples. <h3>Design, Setting, Participants</h3> A prospective cohort study was launched November 1, 2010, 784 participants were followed up every 2 years until December 31, 2020. This nationwide, multicenter, community-based included older...
Importance Many epidemiologic studies have suggested that low levels of plasma leptin, a major adipokine, are associated with increased risk Alzheimer disease (AD) dementia and cognitive decline. Nevertheless, the mechanistic pathway linking leptin AD-related decline is not yet fully understood. Objective To examine association in vivo AD pathologies, including amyloid-beta (Aβ) tau deposition, through both cross-sectional longitudinal approaches among cognitively unimpaired older adults....
Depressive symptoms are common in Alzheimer's disease (AD) and they might influence the course prognosis of AD. Depression could appear anytime disease, either last considerably long or disappear easily. This study is intended to investigate occurrence depression AD risk factors incidence.This targeted 1,272 patients without depressive at start this Korea. A total 775 subjects completed study, was assessed after 12 months. Demographic information collected cognitive functions, overall...
Subsyndromal depression is prevalent and associated with poor outcomes in late life, but its epidemiological characteristics have barely been investigated. The aim of this prospective cohort study to compare the prevalence, incidence risk factors subsyndromal those syndromal including major minor depressive disorders community-dwelling elderly individuals.In a nationwide community-based randomly sampled Korean population aged 60 years or older (N = 6640), was assessed standardized diagnostic...