A5101521722- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Rheology and Fluid Dynamics Studies
- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Diet and metabolism studies
- Nutrition, Health and Food Behavior
- Nutritional Studies and Diet
- Travel-related health issues
- Food Quality and Safety Studies
- Viral Infections and Vectors
- Blood properties and coagulation
- Polysaccharides Composition and Applications
- Biochemical Analysis and Sensing Techniques
- Muscle metabolism and nutrition
- Wound Healing and Treatments
- Consumer Attitudes and Food Labeling
- Functional Brain Connectivity Studies
- Nutrition and Health in Aging
- Regulation of Appetite and Obesity
- Health and Wellbeing Research
- Bioinformatics and Genomic Networks
- Sleep and Wakefulness Research
- Malaria Research and Control
Seoul National University
2023-2025
Seoul National University Hospital
2021-2024
Kyung Hee University
2012-2024
Sungkyunkwan University
2023
Gyeongsang National University
2021-2023
Catholic University of Korea
2003-2022
Pusan National University
2015-2020
The eradication of bacteria from wound sites and promotion healing are essential for treating infected wounds. Nitric oxide (NO) is desirable these purposes due to its ability accelerate broad-spectrum antibacterial effects. We developed an in situ hydrogel-forming/NO-releasing powder dressing (NO/GP), which a during storage forms hydrogel when applied wounds, as novel NO-releasing formulation treat An NO/GP fine (51.5 μm) was fabricated by blending micronizing S-nitrosoglutathione (GSNO),...
The neuropathological links underlying the association between changes in liver function and AD have not yet been clearly elucidated. We aimed to examine relationship markers longitudinal Alzheimer's disease (AD) core pathologies. Data from Korean Brain Aging Study for Early Diagnosis Prediction of Disease, a cohort study initiated 2014, were utilized. Community memory clinic setting. Three hundred forty-seven older adults. Participants underwent baseline 2-year follow-up evaluations,...
Polymicrobial wound infections are a major cause of infectious disease-related morbidity and mortality worldwide. In this study, we prepared nitric oxide (NO)-releasing oxidized bacterial cellulose/chitosan (BCTO/CHI) crosslinked hydrogel to effectively treat polymicrobial infections. Linear polyethyleneimine diazeniumdiolate (PEI/NO) was used as the NO donor. The aldehyde group BCTO amine CHI were hydrogel-based materials; their high loading capacity antibacterial activity on treatment...
Abstract Background Growing evidence suggests that not only cerebrovascular disease but also Alzheimer’s (AD) pathological process itself cause cerebral white matter degeneration, resulting in hyperintensities (WMHs). Some preclinical indicates degeneration may precede or affect the development of AD pathology. This study aimed to clarify direction influence between vivo pathologies, particularly beta-amyloid (Aβ) and tau deposition, WMHs through longitudinal approach. Methods Total 282...
Importance Many epidemiologic studies have suggested that low levels of plasma leptin, a major adipokine, are associated with increased risk Alzheimer disease (AD) dementia and cognitive decline. Nevertheless, the mechanistic pathway linking leptin AD-related decline is not yet fully understood. Objective To examine association in vivo AD pathologies, including amyloid-beta (Aβ) tau deposition, through both cross-sectional longitudinal approaches among cognitively unimpaired older adults....
We developed a Rapid Diagnostic Test (RDT) kit for detecting IgG/IgM antibodies against Zika virus (ZIKV) using monoclonal to the envelope (E) and non-structural protein 1 (NS1) of ZIKV. These proteins were produced baculovirus expression vector with Sf9 cells. Monoclonal J2G7 NS1 J5E1 E selected conjugated colloidal gold produce RDT (Zika RDT). Comparisons ELISA, plaque reduction neutralization test (PRNT), PCR done investigate analytical sensitivity RDT, which resulted in 100% identical...
Seroepidemiological status of toxoplasmosis among the residents Jeju island was surveyed and evaluated by ELISA with crude extract Toxoplasma gondii. The sera 2,348 (male 1,157 female 1,191) were collected checked for IgG antibody titers, which showed 13.2% positive rate (309 sera). rates increasing gradually according to age from 4.3% in teenage 20.6% seventies. significantly different between sex 16.2% male 10.2% (P<0.05). This is regarded relatively higher than any other regions Korea....
The seroepidemiological status of toxoplasmosis was surveyed among the residents Cheorwon-gun, Gangwon-do by means ELISA using a crude extract antigen Toxoplasma gondii. sera 1,661 adult (866 males and 795 females) were collected checked for IgG antibody titers, which showed 17.0% positive rate (282 sera). significantly different between sex; 20.6% 13.1% females (P<0.05). rates higher in fifties (28.7%) forties (20.0%). This Cheorwon-gun is regarded as highest surveys geographical regions...
Abstract Background Low body mass index (BMI) or underweight status in late life is associated with an increased risk of dementia Alzheimer’s disease (AD). However, the relationship between late-life BMI and prospective longitudinal changes in-vivo AD pathology has not been investigated. Methods This study was conducted as part Korean Brain Aging Study for Early Diagnosis Prediction Disease (KBASE). A total 194 cognitive normal older adults were included analysis. at baseline measured,...
Seroepidemiological changes of Toxoplasma gondii infection among the residents islands Gangwha-gun, Incheon for 2 years were surveyed and evaluated by ELISA using a crude extract antigen. In 2010, sera 919 adult in Gyodong-myeon 313 adults Samsan-myeon collected checked IgG antibody titers, which showed 14.5% (133 sera) 19.8% (62 positive rates, respectively. 2011, 955 341 examined, an increase rates to 23.8% (227 31.7% (108 sera), Totally, seroprevalence first year was 15.8% it increased...
A randomized, double-blind, placebo-controlled trial was conducted to confirm whether collagen peptide supplementation for 12 week has a beneficial effect on body fat control in older adults at daily physical activity level. Participants were assigned either the group (15 g/day of peptide) or placebo (placebo drink). Body composition measured by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA). In total, 74 participants (collagen group, n = 37; 37) included...
Abstract Background Altered thyroid hormone levels have been associated with increased risk of Alzheimer's disease (AD) dementia and related cognitive decline. However, the neuropathological substrates underlying link between hormones AD are not yet fully understood. We first investigated association serum in vivo pathologies including both beta-amyloid (Aβ) tau deposition measured by positron emission tomography (PET). Given well-known relationship Aβ pathology AD, we additionally examined...
ELISA has been used for the diagnosis of toxoplasmosis, but it is being gradually replaced by a rapid diagnostic test (RDT). We compared and analyzed RDT results using sera collected during 4 consecutive years from residents Gyodong-do (Island), Incheon-city, Korea. Sera 921, 993, 940, 838 adult were on yearly basis (2010â2013). was performed crude extract T. gondii RH strain antigen IgG/IgM mounted with recombinant fragment major surface (SAG1), GST-linker-SAG1A, applied to sera....
Fruits are generally recommended for a balanced meal, as they good sources of vitamins, minerals, and fiber, which may improve blood glucose control. However, fruits have simple sugars with wide glycemic index (GI) range. The purpose this study was to analyze the sugar content composition determine indices most frequently consumed in Korea, including apple, tangerine, pear, water melon, persimmon, grape, oriental peach. were analyzed by high performance anion-exchange chromatography (Dinonex...
The association between nutritional status and living environment among 703 community-dwelling participants (268 men 435 women) aged 65 years older was assessed. In this cross-sectional survey study, environmental factors, health-related nutrition (the Nutrition Quotient for the Elderly scores; NQ-E) were NQ-E scores significantly higher in than women, as diversity behavior factor (diversity: men, 50.2 ± 16.1; 44.1 17.5; behavior: 59.3 16.9; 54.1 16.6). Participants with a spouse engaging...
An ELISA was developed for the diagnosis of vivax malaria using multiple stage-specific recombinant antigens Plasmodium vivax. The DNA from whole blood a patient used as template to amplify coding regions antigenic domains circumsporozoite protein (CSP-1), merozoite surface (MSP-1), apical antigen (AMA-1), serine repeat (SERA), and exported (EXP-1). Each amplified fragment inserted into pQE30 plasmid induce expression His-tagged in Escherichia coli (M15 strain) by IPTG. proteins were...
Achieving high efficiency in graphene production and printing process simultaneously is challenging, but it needs to be addressed as critical for realizing the commercial viability of printed devices. This study successfully substantiates these requirements by significantly improving subsequently developing an inkjet-printable ink that enables rapid formation percolation network flakes. The integration a flow coil reactor into ultrasonic bath results scalable production, with productivity up...
This study was done to provide an overview of the latest trichomoniasis status in Korea by finding disease clusters and analyzing temporal trends during 2012-2020. Data were obtained from Health Insurance Review & Assessment Service (HIRA) Korea. SaTScan Joinpoint programs used for statistical analyses. Gyeonggi-do had highest average population number cases. The high incidence T. vaginalis infections observed among women aged 40-49 30-39 years (33,830/year 33,179/year, respectively)....
Chikungunya virus (CHIKV), a tropical pathogen, has re-emerged and massive outbreaks abruptly all over the world. Containing many dominant epitopes, envelope E2 protein of CHIKV been explored for vaccination or diagnosis. In present study, antigenicity recombinant expressed intrinsically disorder domain (IUD) was tested detection antibody against through western blot method. The gene IUD inserted into 2 different vectors as GST-E2 MBP-E2 fusion protein, respectively. Two kinds proteins were...
Seroprevalence of Toxoplasma gondii infection among the residents Seokmo-do (Island) in Ganghwa-gun, Incheon, Korea was surveyed for 4 years by a rapid diagnostic test (RDT) using recombinant fragment major surface antigen (SAG1), GST-linker-SAG1A. Sera from 312, 343, 390, and 362 adult were collected on yearly basis 2010 to 2013, respectively. Total positive seroprevalence regardless gender 29.2, 35.3, 38.7, 45.3% Positive male adults 43.9, 48.2, 45.4, 55.3%, which far higher than that...
Crocin, a glycoside of crocetin, has been known as the principal component responsible for saffron's antidiabetic, anticancer, and anti-inflammatory effects. Crocetin, originating from hydrolytic cleavage crocin in biological systems, was subjected to ligand-based virtual screening this investigation. Subsequent biochemical analysis unveiled not crocin, novel dual GPR40 GPR120 agonist, demonstrating marked preference over peroxisome proliferator-activated receptors (PPAR)γ. This compound...
Seroprevalence of Toxoplasma gondii infection among the residents Cheorwon-gun, Gangwon-do, Korea, which partly includes demilitarized zone (DMZ), were surveyed for 4 years and evaluated by RDT using recombinant fragment major surface antigen (SAG1A). Sera from 1336, 583, 526, 583 adult collected on a yearly basis 2010 to 2013, respectively. The total positive seroprevalence was 19.3, 21.9, 23.4, 26.8% in men (23.6, 27.5, 29.5, 34.6%) far higher than women (14.1, 18.3, 19.4, 21.4%), This...
This study evaluates whether blood glucose response differs upon consuming rice cooked in a carbohydrate (carb)-reducing cooker. Rice this way exhibited 19% reduced total (34.0 ± 0.3 vs. 27.6 0.9 g/100 g rice) and 20% calorie (149.0 1.0 120.8 3.7 kcal/100 contents. We measured the (at 0, 15, 30, 45, 60, 90, 120 min) 13 healthy participants after 6 different types: regular white (regular WR, 50 of available (AC)), low-carb WR with equivalent weight as (low-carb (EW)), carb (EC), mixed-grain...