A5100398140- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Advanced Manufacturing and Logistics Optimization
- Neurological Disorders and Treatments
- Nutritional Studies and Diet
- Muscle activation and electromyography studies
- Prosthetics and Rehabilitation Robotics
- Bipolar Disorder and Treatment
- Innovations in Concrete and Construction Materials
- Robotic Path Planning Algorithms
- Cerebrovascular and Carotid Artery Diseases
- Cerebral Palsy and Movement Disorders
- BIM and Construction Integration
- Obstructive Sleep Apnea Research
- Caching and Content Delivery
- Elevator Systems and Control
- Health and Wellbeing Research
- Modular Robots and Swarm Intelligence
- Hydraulic and Pneumatic Systems
- Stress Responses and Cortisol
- Innovative Educational Techniques
- HIV-related health complications and treatments
- Safety Systems Engineering in Autonomy
Seoul National University Hospital
2016-2025
Myongji Hospital
2022-2024
Hanyang University
2008-2024
Seoul National University
2024
Yonsei University
2023
Hyoja Geriatric Hospital
2019-2020
Korea Institute of Oriental Medicine
2017-2020
National Institute of Animal Science
2016
CHA Bundang Medical Center
2015-2016
CHA University
2015-2016
This randomized pilot trial investigated whether primary chemotherapy was feasible in terms of efficacy, survival, toxicity profile, and quality life compared with whole-brain radiotherapy (WBRT) given first chemotherapy-naive patients nonsmall cell lung cancer (NSCLC) synchronous brain metastasis when neurologic symptoms or signs are absent controlled by supportive care.After stratification Eastern Cooperative Oncology Group performance status (ECOG PS) (0-1 vs 2), the number intracranial...
Microglial activation elicits an immune response by producing proinflammatory modulators and cytokines that cause neurodegeneration. Therefore, a plausible strategy to prevent neurodegeneration is inhibit neuroinflammation caused microglial activation. Myricetin, natural flavanol, induces neuroprotective effects inhibiting inflammation oxidative stress. However, whether myricetin inhibits lipopolysaccharide (LPS)-induced in hippocampus cortex regions not known. To test this, we examined the...
Introduction: Proper lipid management is vital for secondary prevention of ischemic stroke; however, not a few patients fail to reach target low-density lipoprotein cholesterol (LDL-C) levels with statin monotherapy. This study aimed provide real-world data on LDL-C achievement using rosuvastatin plus ezetimibe combination therapy (R+E) in stroke who did achieve an level <70 mg/dL statins alone. Methods: multicenter, prospective, observational enrolled adult baseline ≥70 monotherapy from...
Atopic dermatitis (AD), also known as atopic eczema, is chronic pruritic skin disease. AD can increase psychological stress well, increasing glucocorticoid release and exacerbating the associated symptoms. Chronic elevation disturbs neuroendocrine signaling induce neuroinflammation, neurotoxicity, cognitive impairment; however, it unclear whether AD-related elevates glucocorticoids enough to cause neuronal damage. Therefore, we assessed effects of AD-induced in a mouse model. increased...
Recently, the number of high-rise building has increased along with development technology to cope increase in population. Because this, many researches on an automatic façade maintenance system have been conducted satisfy increasing demands maintenance. However, most focused mechanism and composition, while working safety issues not sufficiently dealt with. This paper deals motion control robot which is composed a vertical horizontal moving rail façade. With consideration for robot, these...
Abstract Belgian Malinois (BM), one of the excellent military dog breeds in South Korea, is usually castrated before sexual maturation. Therefore, transfer their genetic features to next generation difficult. To overcome this, testicular cells from 4-month-old BMs were frozen. Testicular thawed after 3 months and cultured StemPro-34 medium. Spermatogonial stem cell (SSC) characteristics determined by transplantation germ cell-derived colonies (GDCs) into empty testes, containing only several...
Importance Many epidemiologic studies have suggested that low levels of plasma leptin, a major adipokine, are associated with increased risk Alzheimer disease (AD) dementia and cognitive decline. Nevertheless, the mechanistic pathway linking leptin AD-related decline is not yet fully understood. Objective To examine association in vivo AD pathologies, including amyloid-beta (Aβ) tau deposition, through both cross-sectional longitudinal approaches among cognitively unimpaired older adults....
To compare gross motor function outcomes in children with moderate to severe degrees of bilateral spastic cerebral palsy (CP) who received either intensive inpatient rehabilitation or intermittent on an outpatient basis.
It is known that children with sleep-disordered breathing (SDB) often have accompanying growth retardation and learning behavior disabilities. However, these results are based mainly on studies of from European North American countries. The objective this study was to investigate the school performance Korean SDB.We enrolled 302 third-grade elementary students an in Seoul. A survey conducted, using information children's parents for diagnosis SDB. height, weight, midterm examination scores,...
Abstract Background Low body mass index (BMI) or underweight status in late life is associated with an increased risk of dementia Alzheimer’s disease (AD). However, the relationship between late-life BMI and prospective longitudinal changes in-vivo AD pathology has not been investigated. Methods This study was conducted as part Korean Brain Aging Study for Early Diagnosis Prediction Disease (KBASE). A total 194 cognitive normal older adults were included analysis. at baseline measured,...
We aimed to investigate the effect of internet-based and in-person cognitive interventions on cognition, mood, activities daily living (ADL) patients with mild moderate Alzheimer's disease (AD) examine whether intervention is as effective intervention. recruited 52 probable AD, whom 42 completed trial. randomly divided participants into control groups at a 1:1 ratio statistically compared neuropsychological test results two groups. In addition, in group were assigned 4 weeks or intervention,...
Abstract Background Altered thyroid hormone levels have been associated with increased risk of Alzheimer's disease (AD) dementia and related cognitive decline. However, the neuropathological substrates underlying link between hormones AD are not yet fully understood. We first investigated association serum in vivo pathologies including both beta-amyloid (Aβ) tau deposition measured by positron emission tomography (PET). Given well-known relationship Aβ pathology AD, we additionally examined...
Although previous studies have suggested that insulin plays a role in brain function, it still remains unclear whether or not has region-specific association with neuronal and synaptic activity the living human brain. We investigated regional pattern of between basal blood resting-state cerebral glucose metabolism (CMglu), proxy for activity, older adults. A total 234 nondiabetic, cognitively normal (CN) adults underwent comprehensive clinical assessment, 18F-fluodeoxyglucose (FDG)-positron...
We suggest a human-robot interfacing method of wearable robot for assistive human upper extremities. It connects the and with multi-axis load-cell, it measures relative force between robot. The control system calculates trajectory end-effector using this signal. In paper, we verify performance proposed through motion elbow E/F (extension/flexion), shoulder E/F, Ab/Ad(abduction/adduction). generated command signal so that user would be able to operate 6-DOF. And, performed subsequent...
This research was conducted to develop the system for an installation-type remote control operation existing excavator without renovation. It also supplement shortcomings of operation, and a applying multi-yoke-type transmission mechanism slide roller mechanism. In addition, this study seeks that would make workspace mapping function lever possible installation -type maintaining excavator's aforestated unique function.
Background Mood disorder has emerged as a serious concern for public health; in particular, bipolar less favorable prognosis than depression. Although prompt recognition of depression conversion to is needed, early prediction challenging due overlapping symptoms. Recently, there have been attempts develop model by using federated learning. Federated learning medical fields method training multi-institutional machine models without patient-level data sharing. Objective This study aims and...
A number of fluorescence imaging techniques for use in the surgical removal glioma have been developed over course long history neurosurgery. Various biomarkers, biochemical agents, and detection systems also developed. This review focuses on 5-aminolevulinic acid (5-ALA), which is used to detect glioma. Numerous forms fluorescence-guided surgery 5-ALA, helpful surgeon. The microscope system observational method generally with while loupe, endoscope, exoscope are simpler alternatives. needed...
Industrial robots are widely used and should be able to easily treat various work pieces. Therefore, a teaching playback method is effective in small-quantity batch production. This paper suggests the mathematical modeling of robotic deburring system, complex target workpiece, an uneven environment. First, proposed that simplifies path for automated efficient teaching, generate feasible trajectory traces out reference, then artificial disturbance on its motion set. The recorded compressed...
Owing to the increasing number of high-rise buildings and large glass facades resulting problem safe effective maintenance, many trials have taken place in last few years develop automated cleaning systems. So as guide robot's movement on facade, this study proposes built-in-guide type building maintenance robot system using additional module such guidance mullion facade. In specific, paper robotic facade which is directly subjected minimize human labor; that improves process efficiency...