A5035434033- Wound Healing and Treatments
- Antimicrobial agents and applications
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Nanocomposite Films for Food Packaging
- Nitric Oxide and Endothelin Effects
- Nanoparticles: synthesis and applications
- Inflammatory Bowel Disease
- Curcumin's Biomedical Applications
- Cervical Cancer and HPV Research
- Bone Tissue Engineering Materials
- Drug Solubulity and Delivery Systems
- Molecular Sensors and Ion Detection
- Cardiac and Coronary Surgery Techniques
- Advanced Cellulose Research Studies
- Acne and Rosacea Treatments and Effects
- Redox biology and oxidative stress
- Dendrimers and Hyperbranched Polymers
- Polymer-Based Agricultural Enhancements
Hasanuddin University
2013-2024
Pusan National University
2014-2021
University of Missouri–Kansas City
2017
Abstract: Nitric oxide (NO)-releasing nanoparticles (NPs) have emerged as a wound healing enhancer and novel antibacterial agent that can circumvent antibiotic resistance. However, the NO release from NPs over extended periods of time is still inadequate for clinical application. In this study, we developed NO-releasing poly(lactic- co -glycolic acid)-polyethylenimine (PEI) (NO/PPNPs) composed acid) PEI/diazeniumdiolate (PEI/NONOate) prolonged release, efficacy, activity. Successful...
In this study, we developed oral core–shell nanoparticles composed of curcumin nanocrystals in the core and chitosan/alginate multilayers shell for inflammation-targeted alleviation ulcerative colitis (UC). The release rate from was low at a pH mimicking stomach small intestine, whereas it higher colon. Further, biodistribution studies gastrointestinal tract mice showed that distribution significantly colon than intestine. Quantitative analysis drugs colonic tissues confocal imaging colons...
Adhesion of nanoparticles (NPs) to the bacterial cell wall by modifying their physicochemical properties can improve antibacterial activity antibiotic. In this study, we prepared positively charged clindamycin-loaded poly (lactic-co-glycolic acid)-polyethylenimine (PLGA-PEI) (Cly/PPNPs) and negatively PLGA NPs (Cly/PNPs) investigated effect NP adhesion bacteria on treatment methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds. The Cly/PPNPs Cly/PNPs were characterized according...
Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. hydrogel properties were improved via polymer blends. Applying this the site allows it self-heal and reattach after damage. work evaluated polyvinyl alcohol (PVA)-based with borax as a crosslinking agent carboxymethyl chitosan property enhancer. Three formulations (F1, F4, F7) developed...
The eradication of bacteria from wound sites and promotion healing are essential for treating infected wounds. Nitric oxide (NO) is desirable these purposes due to its ability accelerate broad-spectrum antibacterial effects. We developed an in situ hydrogel-forming/NO-releasing powder dressing (NO/GP), which a during storage forms hydrogel when applied wounds, as novel NO-releasing formulation treat An NO/GP fine (51.5 μm) was fabricated by blending micronizing S-nitrosoglutathione (GSNO),...
S-nitrosoglutathione (GSNO) has emerged as a potent agent for the treatment of infected cutaneous wounds. However, fabrication GSNO-containing nanoparticles been challenging due to its high hydrophilicity and degradability. The present study aimed fabricate using newly synthesized GSNO-conjugated poly(lactic-co-glycolic acid) (PLGA) (GSNO-PLGA; GPNPs). Since hydrophilic GSNO was covalently bound hydrophobic PLGA, loss during nanoparticle process minimized, resulting in sufficient loading...
Particle shape has been recognized as one of the key properties nanoparticles in biomedical applications including targeted drug delivery. Targeting ability shape-engineered particles depends largely on targeting ligands conjugated particle surface. However, poor capacity for surface ligand conjugation remains a problem anisotropic made with biodegradable polymers such PLGA. In this study, we prepared PLGA abundant conjugatable functional groups by film stretching-based fabrication method...
Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in wound environment implicated as an important regulator all phases healing. Here, we developed NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed S-nitrosoglutathione (GSNO), pluronic F127 (PL), alginate (AL) for treatment infected wounds. The GSNO was incorporated into PL/AL hydrogel, differential scanning calorimetry techniques were used characterization. assessed by vitro NO release,...
α-Mangostin (a xanthone derivative found in the pericarp of Garcinia mangostana L.) and propolis extract (which is rich flavonoids phenols) are known for their antioxidant properties, making them potential supplements treatment oxidative stress-related conditions. However, these two substances have same primary drawback, which low solubility water. The water α-mangostin can be overcome by utilizing nanotechnology approaches. In this study, a propolis-based nanostructured lipid carrier (NLC)...