Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. hydrogel properties were improved via polymer blends. Applying this the site allows it self-heal and reattach after damage. work evaluated polyvinyl alcohol (PVA)-based with borax as a crosslinking agent carboxymethyl chitosan property enhancer. Three formulations (F1, F4, F7) developed...

Telmisartan (TEL) is a promising antihypertensive agent among other angiotensin receptor blockers. However, its oral application limited by poor water solubility. This study presents the successful utilization of biomaterial-based hydrogel-forming microneedles integrated with direct compressed tablet reservoir (HFMN-DCT) for transdermal delivery telmisartan in treatment hypertension. The combination PVP, PVA, and tartaric acid was used HFMN formulation. A range cross-linking temperatures...

Fluconazole (FNL) is one of the first-line treatments for fungal keratitis as it an effective broad-spectrum antimicrobial commonly administered orally or topically. However, FNL has a very low water solubility, limiting its drug formulation, therapeutic application, and bioavailability through tissues. To overcome these limitations, this study aimed to develop inclusion complexes (FNL-IC) with cyclodextrin (α-cyclodextrin, sulfobutylether-β-cyclodextrin, hydroxypropyl-γ cyclodextrin)...

Glochidion philippicum has been suggested to exhibit considerable pharmacological potential, yet its chemical composition and bioactivity remain inadequately explored. The aim of this study was investigate the fingerprint antioxidant properties G. leaf extracts using Fourier-transform infrared spectroscopy (FTIR) with chemometric analyses, in vitro vivo evaluations. Four extraction methods (maceration, reflux, ultrasound-assisted (UAE), microwave-assisted (MAE)) were optimized water, 70%...

Etlingera elatior (Jack) R.M. Smith is an endemic plant of North Luwu, Indonesia. It used traditionally as acidifiers in food. This study aim to evaluate the antioxidant activity, total phenolic and flavonoid contents ethanol leaf extract E. elatior. The dried leaves were extracted by maceration 70% at room temperature for three days. activity was assessed using 2,2-diphenyl-1-picrilhydrazyl (DPPH) 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays ferric...

Context: Premature aging usually occurred due to free radicals reducing the skins’ physiological functions. Muntingia calabura, a plant containing rich antioxidants, has potential overcome this problem. Aims: To evaluate antioxidant capacity of M. calabura in inhibiting premature process, be potentially developed into an antiaging active ingredient. Methods: The samples were extracted using ethanol 96%, and processed n-hexane, ethyl acetate, fractions, respectively. Total phenolic content...

Periodontitis can be treated by regenerating periodontal tissue using a bone graft. Several natural materials such as chitosan and minerals hydroxyapatite developed to increase regeneration. Chitosan has high potential in healing wounds. Hydroxyapatite excellent properties biocompatibility, osteoconductive, osteoinductive, osteogenesis, making it an ideal material for soft hard obtained from the shells of crustaceans, crabs (Portunus pelagicus).To assess effectiveness combination gel powder...

Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia due to abnormal insulin secretion, action, or both. Breadfruit has been used in traditional medicine for diabetes mellitus. This study aims see the effect of giving ethanol breadfruit leaf extract pancreatic damage induced alloxan–nicotinamide. Rats were with alloxan–nicotinamide and grouped into 4 groups, namely group I (normal) without treatment, II (positive) given metformin 100 mg/kg body weight (BW), III...

Background: Curcumin has been suggested to be useful in the treatment of numerous diseases, including autoinflammation, that implicated some pathological conditions. Experimentally, autoinflammatory phenotypes were observed short-lived Peptidoglycan recognition protein LB (PGRP-LB) mutant Drosophila melanogaster. Objective: This study aimed determine effect curcumin on expression ageing-related genes model D. Method: was performed using five test groups untreated control, solvent and three...

Penyakit degenerative disebabkan karena antioksidan yang ada didalam tubuh tidak mampu menetralisir peningkatan konsentrasi radikal bebas, sehingga perlu adanya dari luar untuk menghancurkan bebas dapat menyebabkan kerusakan sel. Kulit buah jeruk Bali merupakan salah satu tanaman diketahui memiliki kandungan senyawa flavonoid bersifat antioksidan. Tujuan penelitian ini adalah mengetahui kimia dan aktivitas ekstrak etanol kulit Bali. Identifikasi dilakukan secara kualitatif kuantitatif,...

This research was basic to identify the effect of turmeric extract tested by in vivo method. The purpose this study differences length wound at each concentration gel preparations on days 3, 7, and 14, as well healing time and, most effective for healing.This is an experimental laboratory with animals using post-test only control groups, type used a pre-clinical test (pre-clinical trial) female rabbits. sample size 12 rabbits grouped randomly. group's wounds measured observed 14. Gel...

Diabetes mellitus and its complications are among the primary causes of death disability. Retinopathy, cardiovascular disease, neuropathy develop progressively with prolonged hyperglycemia. Finding an effective secure drug fewer side effects to handle diabetes-related is necessary. Numerous scientists launching new initiatives investigate plant sources, which known contain a vast array active agents. An edible marine algae, Caulerpa racemosa, was reported have bioactivities including...

Drug discovery is a complex process, and the use of comprehensive approach deemed necessary to discover new chemical entities with novel mechanisms action. This research was carried out determine whether Drosophila melanogaster can serve as an appropriate model organism in initial screening drug candidates immunomodulatory activities. To test this, we performed phenotypic assay molecular analysis investigate activities aspirin, dexamethasone, curcumin, epigallocatechin gallate (EGCG), that...

Cabai merupakan salah satu komoditas yang berkontribusi besar pada inflasi di Indonesia. Produksi cabai sering mengalami serangan hama dan penyakit penyebab utama kegagalan panen. Akibat dari tersebut dapat mencapai kerugian sebesar 40-50%. Kerugin menyebabkan petani tidak mau mengambil resiko menempuh jalan singkat yaitu denga penggunaan pestisida kimia secara berlebihan langsung meninggalkan residu pestisida. Tujuan penelitian ini adalah untuk mengetahui kadar klorpirifos propenofos...

The antioxidant capacity of Artocarpus altilis leaf extract may offer protection against stress oxidative-induced damage to pancreatic cells. This study aimed examine the effect on islets structure, blood glucose (BG), and insulin serum levels in alloxan-induced diabetic rats. Diabetes mellitus was induced rats with an intraperitoneal injection alloxan (155 mg/kg). Rats’ BG were measured daily. Only >250 mg/dL (n = 25) proceeded receive different treatments: placebo, at dose 100, 200, or 400...

Purpose: To examine the chemopreventive activity of curcumin analogues, hexagamavunone-0 (HGV- 0) and gamavutone-0 (GVT-0), compared to in a colorectal cancer model Wistar rats.Methods: Rats (n = 25) were assigned one five groups 5 each group). Colorectal was induced control group with subcutaneous injection 1,2-dimethylhydrazine (DMH) 60 mg/kg once week for 15 weeks. In addition DMH injection, treatment treated (20, 40, or 80 mg/kg), (GVT-0; 20, hexagamavunone (HGV-0; mg/kg) orally twice...

Parasetamol, kafein dan propifenazon dikombinasikan bersama dalam sediaan obat untuk memberikan efek analgetik. Penggunaan kombinasi semakin meningkat mencapai terapi yang lebih baik penurunan toksisitas sehingga sangat penting mengawasi kandungan zat aktif formulasi farmasetik. Desain penelitian adalah eksperimental menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT) dengan detektor UV pada 273 nm, kolom ODS, fase gerak metanol air (50:50), laju alir 0,6 mL/menit volume penyuntikan...

Penggunaan pestisida di Indonesia sudah merupakan bagian yang tidak terpisahkan dalam sistem pertanian. Klorpirifos salah satu kelompok golongan organofosfat banyak digunakan untuk membunuh berbagai serangga. Adanya residu klorpirifos dapat menyebabkan gangguan kesehatan sehingga deteksi produk pangan hal penting. Penelitian ini dilakukan mengetahui kadar pada beras berasal dari Kecamatan Baebunta, Kabupaten Luwu Utara dan keamanannya dikonsumsi. Sampel diambil langsung beberapa petani...

Objective:The purpose of this study was to identify differences in wound healing and time at each concentration turmeric extract gel (Curcuma longa Linn) base on days 3, 7 14, the most effective for cuts female rats (Rattus Novergicus).Method: This an experimental laboratory using a post-test only with control group.This used 16 rats, 3 treatment groups, 1 group (each consisted 4 mice).Female were injured back section by slashing along 1.5 cm depth 0.2 cm.The given 5%, 10%, 15%, base.This...

The increasing case of antibiotic resistence has become an important problem to be faced in treating the infection diseases. diversities microbia, especially actinomycetes bacteria which originated from rizosphere soil medicinal plant, opened a chance for discovering metabolites can used solving resistant pathogenic problems. aim this research was isolate actinobacteria plant Orthosipon stamineus as producer anti-multidrug resistances compounds. Three isolates been isolated rhizosphere named...