A5073912605- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Drug Transport and Resistance Mechanisms
- Sphingolipid Metabolism and Signaling
- Autophagy in Disease and Therapy
- Advanced Drug Delivery Systems
- Inflammasome and immune disorders
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Genomics, phytochemicals, and oxidative stress
- Stress Responses and Cortisol
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Probiotics and Fermented Foods
- Sirtuins and Resveratrol in Medicine
- Microscopic Colitis
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Cell death mechanisms and regulation
- Hormonal Regulation and Hypertension
- Digestive system and related health
- Endoplasmic Reticulum Stress and Disease
- Telomeres, Telomerase, and Senescence
Pusan National University
2016-2025
Emory University
2023-2024
Oakland University
2019
University of California, Los Angeles
2008-2018
Massachusetts Eye and Ear Infirmary
2005-2010
Harvard University
2005-2010
Smith-Kettlewell Eye Research Institute
2005-2010
The University of Texas at Austin
2005
University of Arizona
2004-2005
Beth Israel Deaconess Medical Center
2005
Commensal and enteroinvasive microbes in the human gut release bacterial flagellin, a specific microbial ligand of Toll-like receptor 5 (TLR5). However, pathophysiological role flagellin gastrointestinal inflammation has not been determined. Here we evaluated using native colonic mucosa mouse colitis model dextran sulfate sodium (DSS). We demonstrate that, intact mucosa, flagellin/TLR5 response occurs only after exposure to basolateral, apical, surface, implying basolaterally polarized TLR5...
Abstract A wealth of data implicates that ErbB receptors have essential roles in tumor development. Probiotic bacteria are known to exert an anticancer activity animal studies. Bacillus polyfermenticus (B.P.), a probiotic bacterium, has been clinically used for variety gastrointestinal disorders East Asia. Here, we investigated the effect B.P. on growth tumors and its putative mechanism actions. Conditioned medium cultures (B.P. CM) inhibited human colon cancer cells including HT‐29, DLD‐1...
Colon-targeted oral nanoparticles (NPs) have emerged as an ideal, safe, and effective therapy for ulcerative colitis (UC) owing to their ability selectively accumulate in inflamed colonic mucosa. Cyclosporine A (CSA), immunosuppressive agent, has long been used rescue severe steroid-refractory UC. In this study, we developed CSA-loaded dual-functional polymeric NPs composed of Eudragit® FS30D a pH-sensitive polymer targeted delivery the colon, poly(lactic-co-glycolic acid) (PLGA)...
Abstract Lower socioeconomic status (SES) is related to increased incidence and mortality due chronic diseases in adults. Association between SES variables gut microbiome variation has been observed adults at the population level, suggesting that biological mechanisms may underlie associations; however, there a need for larger studies consider individual- neighborhood-level measures of racially diverse populations. In 825 participants from multi-ethnic cohort, we investigated how shapes...
The lysosomal protease cathepsin B has been implicated in a variety of pathologies including pancreatitis, tumor angiogenesis, and neuronal diseases. We used tube formation assay to investigate the role angiogenesis. When cultured between two layers collagen I, primary endothelial cells formed tubes response exogenously added VEGF. Overexpressing reduced VEGF-dependent response, whereas pharmacologically or molecularly suppressing eliminated dependence on exogenous However, still required...
Flavonoids have been demonstrated to provide health benefits in humans. Baicalein (5,6,7-trihydroxyflavone) is a phenolic flavonoid compound derived mainly from the root of Scutellaria baicalensis Georgi, medicinal plant traditionally used oriental medicine. widely Korean and Chinese herbal medicines as anti-inflammatory anticancer therapy. However, molecular mechanisms its activity remain poorly understood warrant further investigation. This study was performed investigate effect baicalein...
Toll-like receptors (TLRs) associate with adaptor molecules (MyD88, Mal/TIRAP, TRAM, and TRIF) to mediate signaling of host-microbial interaction. For instance, TLR4 utilizes the combination both Mal/TIRAP-MyD88 (MyD88-dependent pathway) TRAM-TRIF (MyD88-independent pathway). However, TLR5, specific receptor for flagellin, is known utilize only MyD88 elicit inflammatory responses, an involvement other has not been suggested in TLR5-dependent signaling. Here, we found that TRIF involved...
The effects of sulforaphane (a natural product commonly found in broccoli) was investigated on hypoxia inducible factor-1α (HIF-1α) expression HCT116 human colon cancer cells and AGS gastric cells. We that hypoxia-induced HIF-1α protein cells, while treatment with markedly concentration-dependently inhibited both cell lines. Treatment vascular endothelial growth factor (VEGF) modulated the effect stability. However, degradation by not mediated through 26S proteasome pathway. also inhibition...
Macroautophagy/autophagy is a central mechanism by which cells maintain integrity and homeostasis, endotoxin-induced autophagy plays important roles in innate immunity. Although TLR4 stimulation mediated lipopolysaccharide (LPS) also upregulates hepatocytes liver, its physiological role remains elusive. The objective of this study was to determine the LPS-induced regulation liver lipid metabolism. LPS treatment (5 mg/kg) increased autophagy, as detected LC3 conversion transmission electron...
Lactobacillus plantarum (L. plantarum) is a probiotic that has emerged as novel therapeutic agents for managing various diseases, such cancer, atopic dermatitis, inflammatory bowel disease, and infections. In this study, we investigated the potential mechanisms underlying anticancer effect of metabolites L. plantarum. We cultured cells to obtain their metabolites, created several dilutions, used these solutions treat human colonic Caco-2 cells. Our results showed 10% dilution decreased cell...
Frequency of gram-negative bacteria is markedly enhanced in inflamed gut, leading to augmented LPS the intestine. Although intestine considered harmless and, rather, provides protective effects against epithelial injury, it has been suggested that causes intestinal inflammation, such as necrotizing enterocolitis. Therefore, direct remain be studied. In this study, we examine effect colon mice instilled with by rectal enema. We found on luminal side elicited inflammation small remotely, not...