A5006158337- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Bone health and treatments
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Pituitary Gland Disorders and Treatments
- Bone and Joint Diseases
- Vitamin D Research Studies
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Sphingolipid Metabolism and Signaling
- Genetic Associations and Epidemiology
- Hip and Femur Fractures
- Axon Guidance and Neuronal Signaling
- Body Composition Measurement Techniques
- Thyroid Disorders and Treatments
- Adipose Tissue and Metabolism
- Parathyroid Disorders and Treatments
- Alkaline Phosphatase Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
University of Ulsan
2016-2025
Asan Medical Center
2016-2025
Ulsan College
2016-2025
Kyungpook National University
2012-2024
Pohang University of Science and Technology
2024
Seoul National University Hospital
2023
Soon Chun Hyang University Cheonan Hospital
2015
University of Otago
2015
Catholic University of Korea
2014
Daejeon St. Mary's Hospital
2014
Hyperhomocystinemia is a modifiable risk factor for osteoporosis and fracture. Physiologic concentrations of Hcy directly activate osteoclast formation activity through stimulation p38 MAPK integrin beta3. The effects were mediated by generation intracellular ROS.Hyperhomocysteinemia its related bone fractures. It has been reported that resorption turnover rate increased in hyperhomocystinemia. Using mouse marrow cells, we examined the direct homocysteine (Hcy) on activity.Osteoclast was...
Abstract Despite extensive experimental and animal evidence about the detrimental effects of iron its overload on bone metabolism, there have been no clinical studies relating stores to loss, especially in nonpathologic conditions. In present study, we performed a large longitudinal study evaluate serum ferritin concentrations relation annualized changes mineral density (BMD) healthy Koreans. A total 1729 subjects (940 postmenopausal women 789 middle-aged men) aged 40 years or older who had...
Coupling is the process that links bone resorption to formation in a temporally and spatially coordinated manner within remodeling cycle. Several lines of evidence point critical roles osteoclast-derived coupling factors regulation osteoblast performance. Here, we used fractionated secretomic approach identified axon-guidance molecule SLIT3 as clastokine stimulated migration proliferation by activating β-catenin. also inhibited suppressing osteoclast differentiation an autocrine manner. Mice...
Abstract Bone area is one measure of bone size that easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study DXA the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci replicate in samples European East Asian descent ( N = 13,608 – 21,277). Eight associate with osteoarthritis, including rs143384 GDF5 missense variant COL11A1 (rs3753841). The strongest rs11614913[T] microRNA MIR196A2 gene associates P 2.3 × 10 −42 , β...
Purpose The Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP) was proposed predicting the metastatic potential of pheochromocytoma paraganglioma to overcome limitations Scaled Score (PASS). However, date, no study validating GAPP has been conducted, previous studies did not include mutations in succinate dehydrogenase type B (SDHB) gene score calculation. In this retrospective cohort study, we validated prediction ability assessed whether it would be improved by inclusion...
Leptin, the Ob gene product, has emerged recently as a key regulator of bone mass. However, mechanism mediating leptin effect remains controversial. Because action is dependent on its receptors, we analyzed their expression in osteoblast-lineage primary human marrow stromal cells (hBMSC). Both short and long forms receptors were detected hBMSC. Leptin significantly decreased viability This cytotoxic was prevented by Z-Val-Ala-Asp-fluoromethylketone, pan-caspase inhibitor, implicating that...
The metabolic syndrome (MS) is associated with increased life-time risk for atherosclerotic cardiovascular disease. While some reports suggest that MS and/or insulin resistance low serum free T4 (FT4) level in euthyroid subjects, this remains a controversial issue.To clarify the association of FT4 presence and its components healthy subjects.For 44,196 subjects (including 25,147 males) not taking thyroid hormone or antithyroid-drug without liver renal disease who participated routine health...
Studies in aged mice support a role for kynurenine, tryptophan metabolite, age-induced bone loss; however, the of kynurenine human metabolism is not well understood.To assess whether level marrow (BM) aspirates, directly reflecting microenvironment, associated with osteoporosis-related phenotypes and biochemical markers.A case-control study conducted clinical unit.BM samples were collected from 72 patients at time hip surgery either fragility fracture (HF) (n = 27) or other causes 45). In...
ABSTRACT Osteoporosis is a common, but silent disease until it complicated by fractures that are associated with morbidity and mortality. Over the past few years, although deep learning-based diagnosis on chest radiographs has yielded promising results, osteoporosis screening remains unexplored. Paired data 13,026 dual-energy X-ray absorptiometry (DXA) results from Health Screening Promotion Center of Asan Medical Center, between 2012 2019, were used as primary dataset in this study. For...
Summary Objective Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels defined statistically, some individuals with normal may have mild hyperthyroidism and reduced We therefore determined whether serum correlate mineral density (BMD). Design A cross‐sectional hospital‐based survey. Participants Nine hundred fifty‐nine healthy postmenopausal women. Measurements measured BMD at lumbar spine femoral neck using dual energy X‐ray absorptiometry,...
Most genome-wide association (GWA) studies have focused on populations of European ancestry with limited assessment the influence sequence variants other ethnicities. To determine whether markers that we recently shown to associate Bone Mineral Density (BMD) in Europeans also BMD East-Asians analysed 50 from 23 genomic loci samples Korea (n = 1,397) and two Chinese Hong Kong sample sets 3,869 n 785). Through this effort identified fourteen associated East-Asian using a false discovery rate...