A5057271238- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Micro and Nano Robotics
- Molecular Communication and Nanonetworks
- Peripheral Artery Disease Management
- Infective Endocarditis Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Issues in Pregnancy
- Aortic aneurysm repair treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetic Syndromes and Imprinting
- Aortic Disease and Treatment Approaches
- Coronary Artery Anomalies
- Atrial Fibrillation Management and Outcomes
- 3D Printing in Biomedical Research
- Kawasaki Disease and Coronary Complications
- Knee injuries and reconstruction techniques
- Kruppel-like factors research
- Cancer Research and Treatments
- Lipoproteins and Cardiovascular Health
- Vascular Procedures and Complications
- Microfluidic and Bio-sensing Technologies
- Venous Thromboembolism Diagnosis and Management
Samsung Medical Center
2020-2025
Sungkyunkwan University
2020-2025
Eulji University
2023-2025
Sejong General Hospital
2014-2023
Chungbuk National University Hospital
2023
Asan Medical Center
2000-2022
University of Ulsan
2000-2017
Ulsan University Hospital
2017
Ulsan College
2017
Sejong Institute
2017
Coupling is the process that links bone resorption to formation in a temporally and spatially coordinated manner within remodeling cycle. Several lines of evidence point critical roles osteoclast-derived coupling factors regulation osteoblast performance. Here, we used fractionated secretomic approach identified axon-guidance molecule SLIT3 as clastokine stimulated migration proliferation by activating β-catenin. also inhibited suppressing osteoclast differentiation an autocrine manner. Mice...
Reducing mortality among severe trauma patients requires the establishment of an effective emergency transportation system and rapid transfer to appropriate medical facilities. Machine learning offers significant potential enhance efficiency quality these services. A retrospective secondary analysis was conducted using region-specific survey data. The focused on socio-economic characteristics, mechanisms injury, injury severity, variables indicating effectiveness in optimizing machine...
Background: Remnant tensioning (RT) anterior cruciate ligament (ACL) reconstruction has been reported to have excellent postoperative outcomes for femoral-side tears. However, the influence of remnant continuity (RC) on results after RT ACL remains unclear. Purpose: To investigate effects RC clinical, radiological, and second-look arthroscopic Study Design: Cohort study; Level evidence, 3. Methods: This study included 94 patients who underwent using hamstring tendon tears between 2015 2020....
In this study, a new type of targeted bacteriobots is prepared and investigated as therapeutic strategy against solid tumors. Maleimide‐functionalized hyaluronic acid (HA) polymer synthesized cross‐linked with four‐arm‐thiolated polyethylene glycol (PEG‐SH) to form HA microbeads diameter 8 μm through the Michael‐type addition. Docetaxel (DTX)‐loaded nanoparticles are encapsulated in HA–PEG sustained vitro drug‐release pattern DTX from observed for up 96 h. Dual‐targeted using CD 44...
Abstract Objectives We sought to investigate the long‐term clinical outcomes of patients with coronary artery aneurysm (CAA) after drug‐eluting stent (DES) implantation, compared without CAA. Background CAA developed DES implantation is a rare but associated poor outcome. Methods retrospectively 78 269 who underwent for complex lesions (controls). The primary endpoint was defined as major adverse cardiac events (MACE), composite all‐cause death, nonfatal myocardial infarction (MI), and...
Experimental studies have demonstrated KLOTHO gene polymorphism might be associated with vascular atherosclerosis and calcification. However, the impact of this genetic variant on human coronary arteries still remains to elucidated. We investigated effect a artery stenosis Four hundred thirty-four patients referred for chest pain were enrolled. All underwent angiography G395A gene. Coronary disease (CAD) was defined as ≥ 50% diameter in at least one artery. The other considered controls....
Abstract Megakaryocytes (MKs) play key roles in regulating bone metabolism. To test the of MK-secreted factors, we investigated whether MK and promegakaryocyte (pro-MK) conditioned media (CM) may affect formation resorption. K562 cell lines were differentiated into mature MKs. Mouse marrow macrophages osteoclasts, MC3T3-E1 cells used for osteoblastic experiments. Bone was determined by a calvaria assay vivo . Micro-CT analyses performed femurs ovariectomized female C57B/L6 Balb/c nude mice...
Abstract Background The influence of intensive glucose control in diabetic patients on the macrovascular outcomes is controversial. Thus, this study aimed to elucidate effect preprocedural hemoglobin A1c (HbA1c) clinical after endovascular therapy for lower extremity artery disease (LEAD) patients. Methods Diabetic were enrolled from retrospective cohorts a Korean multicenter registry and divided according HbA1c level during index admission into optimal (< 7.0%) or suboptimal (≥ glycemic...
ABSTRACT Biocompatibility, sensing, and self‐actuation are very important features for a therapeutic biomedical microrobot. As new concept tumor theragnosis, this paper proposes monocyte‐based microrobots, which combining the phagocytosis engulfment activities containing human acute monocytic leukemia cell line (THP‐1) with various sized polystyrene microbeads engulfed instead of drug. For validation blood vessel barrier‐penetrating activity microrobot, we fabricate migration assay...
The incidence and prognostic implications of atrial fibrillation (AF) in patients with severe aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI) are controversial, especially for Korean patients. Furthermore, the pattern antithrombotic therapy these is unknown. present study sought to identify impact AF on TAVI demonstrate status patients.A total 660 who underwent AS were recruited from nationwide K-TAVI registry Korea. enrolled stratified into sinus rhythm (SR) groups....
The bacteria-based microrobot (Bacteriobot) is one of the most effective vehicles for drug delivery systems. bacteriobot consists a microbead containing therapeutic drugs and bacteria as sensor an actuator that can target guide to its destination. Many researchers are developing microrobots establishing model. In spite these efforts, motility model bacteriobots steered by chemotaxis remains elusive. Because bacterial movement random should be described using stochastic model, response...
The aim of this trial was to compare the safety and efficacy a thin-strut biodegradable polymer sirolimus-eluting cobalt-chromium stent (Orsiro) thick-strut biolimus-eluting (BioMatrix).This randomised, open-label, non-inferiority conducted among patients undergoing percutaneous coronary intervention. primary endpoint target lesion failure (TLF). Between July 2014 September 2017, we randomly assigned 2,341 BioMatrix stents (n=1,166) or Orsiro (n=1,175). We analysed 2,327 who completed...
Comparative studies of ultrathin-strut biodegradable polymer sirolimus-eluting stent (BP-SES) have reported promising results and validated its excellent outcomes in terms safety efficacy. However, there are limited comparing BP drug-eluting stents with struts different thicknesses. We compared the long-term clinical patients treated an BP-SES or a thick-strut biolimus-eluting (BP-BES).The BIODEGRADE trial (Biomatrix Orsiro Drug-Eluting Stents Angiographic Result Patients With Coronary...
Mitral regurgitation (MR) is a frequent complication of left-ventricular dysfunction, with an incidence ranging from 13 to 59% after acute myocardial infarction (AMI), which associated poor clinical outcome. The aim this study was assess the and angiographic characteristics MR, predictors outcomes MR AMI in those who were successfully treated primary percutaneous coronary intervention (PCI) using drug-eluting stent.We analyzed multicenter all-comer registry identified 4748 patients between...
Objective To compare the long-term safety and clinical efficacy of endovascular treatment for TASC-II type C/D femoropopliteal lesion compared with A/B in Korea. Methods A total 179 limbs [TASC-II (group I, n = 105 limbs) II, 74 limbs)] were retrospectively analyzed from patients who underwent angioplasty or without primary stent implantation between February 2008 November 2012 at two medical centers South The major adverse limb event was defined as a composite target revascularization,...
The Sapien 3 (S3) valve has not been compared to the XT (SXT) in Korea. We procedural and clinical outcomes between 2 devices.A total of 189 patients who underwent transcatheter aortic replacement (TAVR) with S3 (n=95) or SXT (n=94) was analyzed. primary endpoint cardiovascular mortality at 1 year. median follow-up duration 438 days.The Society Thoracic Surgeons score similar groups. device success rate (90.4% vs. 97.9%; p=0.028) higher than SXT. showed significantly fewer cases moderate...
Abstract Background The effect of chronic total occlusion (CTO) revascularization on survival remains controversial. Furthermore, data regarding outcome differences for CTO based left ventricular systolic function (LVSF) are limited. differential outcomes from in patients with preserved LVSF (PLVSF) versus reduced (RLVSF) were assessed. Methods A 2,173 divided into either a PLVSF ( n = 1661, Ejection fraction ≥ 50%) or RLVSF 512, < group. Clinical compared between successful (SCR) optimal...
Coronary artery fistula is an uncommon congenital malformation that generally drains into the main pulmonary or right side of heart. This a case report on bilateral coronary fistulas communicating with and left ventricle. A 65-year-old woman was investigated for recurrent chest pain. angiography revealed this anomalous connection without evidence atherosclerotic disease. The rarity involving both ventricle emphasized.