A5100681611- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Acute Myocardial Infarction Research
- Vascular Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Lipoproteins and Cardiovascular Health
- Synthetic Organic Chemistry Methods
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Coronary Artery Anomalies
- Cardiac electrophysiology and arrhythmias
- Helicobacter pylori-related gastroenterology studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Renal and Vascular Pathologies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Microbial infections and disease research
- Cardiac Arrhythmias and Treatments
- Bacteriophages and microbial interactions
- Diagnosis and Treatment of Venous Diseases
- Hormonal Regulation and Hypertension
Soonchunhyang University
2016-2025
SHARE
2024
Singapore-HUJ Alliance for Research and Enterprise
2024
Science Health Allied Research Education
2024
Soonchunhyang University Hospital
2011-2024
Soon Chun Hyang University Cheonan Hospital
2014-2023
Yonsei University
2010-2023
Hanyang University Medical Center
2023
Gangnam Severance Hospital
2023
Eulji University
2021
Abstract Background and Aims Drug-coated balloons (DCBs) have demonstrated favourable outcomes following endovascular therapy for femoropopliteal artery (FPA) disease. However, uncertainty remains whether the use of intravascular ultrasound (IVUS) can improve DCBs. Methods This prospective, multicentre, randomized trial, conducted at seven centres in South Korea, compared IVUS-guided vs. angiography-guided angioplasty treating FPA disease with Patients were assigned to receive (n = 119) or...
Importance The potential benefits of P2Y12 inhibitor deescalation for acute myocardial infarction after percutaneous coronary intervention may be influenced by body mass index (BMI). Objectives To investigate the association BMI on outcomes 12 months in patients with who were initially treated aspirin plus ticagrelor 1 month, and to assess whether BMI-based switching from (active control strategy) clopidogrel (deescalation is associated individualized benefits. Design, Setting, Participants...
P2Y12 inhibitor monotherapy after dual antiplatelet therapy (DAPT; a plus aspirin) for brief duration has recently emerged as an attractive alternative patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent.
The activation of alkynyl allyl silanes with a cationic gold catalyst in the presence alcohols provides vinyl that contain group at β-position and alkoxysilyl cis-orientation. bond reorganization process is most consistent involvement carbocationic intermediate, which undergoes nucleophilic attack by an alcohol selectively silicon center. cis-vinyl silyl ether products can be further elaborated ring-closing cross metathesis to form more substituted 1,4-dienyl silanes.
Background: There is very little information about the relationship between hyperuricemia, acute kidney injury (AKI) and in-hospital mortality. Methods Results: With a retrospective analysis of medical records, 1,247 patients who had percutaneous coronary intervention (PCI) were investigated. AKI was defined as an increase in serum creatinine ≥0.5mg/dl or ≥50% over baseline within 7 days PCI. The association with clinical, biochemical procedural variables examined. In addition, hyperuricemia...
Inappropriate antiplatelet therapy discontinuation increases the risk of thrombotic complications and bleeding after dental procedures. To determine platelet reactivity recovery time aspirin withdrawal in vivo, our study was conducted patients with low-risk cardiovascular disease who can stop administration following guidelines stipulated by American College Chest Physicians. The it takes for activity to normalize diagnostic accuracy testing methods were assessed a residual multiple...
l-Fucokinase was purified to apparent homogeneity from pig kidney cytosol. The molecular mass of the enzyme on a gel filtration column 440 kDa, whereas SDS gels single protein band 110 kDa observed. This 110-kDa labeled in concentration-dependent manner by azido-[32P]ATP, and labeling inhibited cold ATP. subjected endo-Lys-C digestion, several peptides were sequenced. These showed very little similarity other known sequences. phosphorylated l-fucose using ATP form β-l-fucose-1-P. Of many...
Thrombopoietin (Tpo) is a glycoprotein growth factor that supports hematopoietic stem cell survival and expansion the principal regulator of megakaryocyte differentiation. Several small, nonpeptidyl molecules have been identified as selective human Tpo receptor (hTpoR) agonists. To understand how small molecule mimic SB394725 interacts activates hTpoR, we performed domain swap mutagenesis studies. The results suggest specifically with extracellular juxtamembrane region (JMR) transmembrane...
A tandem reaction sequence involving relay metathesis-induced enyne RCM and metallotropic [1,3]-shift is an effective tool to construct cyclic alkenes with embedded 1,5-dien-3-yne moieties from acyclic precursors containing a 1,3-diyne. Total syntheses of (+)-asperpentyn, (-)-harveynone, (-)-tricholomenyn have been accomplished by implementing this metathesis-based as the key step.
Background. Although glyphosate intoxication has been considered minimally toxic in animals, severe toxicity observed humans due to surfactant. We aimed examine the potential therapeutic effects of intravenous lipid emulsion (ILE) on patients with acute intoxication. Methods. This study enrolled 64 glyphosate-intoxicated allocation two groups: those treated ILE (ILE group, n = 22), and control only supportive (conservative) care. Control were selected by matching for amount ingested time...
Abstract Objective In spite of cytoprotective and anti‐inflammatory actions, conventional licorice extracts (c‐lico) were limitedly used due to serious side effects glycyrrhizin. As our group had successfully isolated special (s‐lico) lowering troublesome glycyrrhizin, but increasing licochalcone A, we have compared anti‐inflammatory, antioxidative, actions s‐lico c‐lico against either in vitro or vivo H elicobacter pylori infection. Methods RT ‐ PCR W estern blot performed check action...
The popliteal artery is generally regarded as a "no-stent zone." Limited data are available on the outcomes of drug-coated balloons (DCBs) for disease. This study aimed to evaluate 12-month clinical among patients who received DCB treatment atherosclerotic prospective, multicenter registry enrolled 100 from 7 Korean endovascular centers underwent therapy using IN.PACT (Medtronic) symptomatic primary endpoint was patency and secondary clinically driven target lesion revascularization...
Using a new-generation drug-eluting stent, we compared the 2-year clinical outcomes of patients with diabetes mellitus (DM) and non-DM concomitant non-ST-segment elevation myocardial infarction (NSTEMI) an ST-segment (STEMI) who underwent percutaneous coronary intervention. A total 11,798 acute were classified into two groups: DM (NSTEMI, n = 2399; STEMI, 2693) 2694; 4012). The primary outcome was occurrence major adverse cardiac events (MACE), defined as all-cause death, recurrent...
Abstract The immunochromatographic assay (ICA) using a nitrocellulose (NC) membrane offers several advantages. This technique is rapid and straightforward method in contrast to other immunoassays. Polydiacetylene (PDA) vesicles have unique optical properties, displaying red color fluorescence at the same time. In this system, red‐phase PDA are used as fluorescent dye well surface for immobilized hepatitis B antibody (HBsAb). has remarkable stability compared with dyes. study, most suitable...
Background Coronary artery spasm ( CAS ) is a well‐known endothelial dysfunction, and major cause of vasospastic angina VSA ). The renin–angiotensin system RAS known to be closely associated with function. However, there are only few studies that investigated the impact inhibitor on long‐term clinical outcomes in patients. Methods Results A total 3349 patients no significant coronary disease, diagnosed by acetylcholine provocation test were enrolled for this study. Significant was defined as...
Gaegurin 4 (GGN4) is a 37‐residue antimicrobial peptide isolated from the skin of Korean frog, Rana rugosa . This shows broad range activity against prokaryotic cells but very little hemolytic human red blood cells. The solution structure GGN4 was studied by using circular dichroism (CD) and NMR spectroscopy. CD investigations revealed that adopts mainly an α‐helical conformation in trifluoroethanol/water solution, dodecylphosphocholine SDS micelles, random aqueous solution. By both...