A5100677617- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Genomics and Phylogenetic Studies
- Natural product bioactivities and synthesis
- Probiotics and Fermented Foods
- Phytochemicals and Antioxidant Activities
- Diabetes Treatment and Management
- Seismic Imaging and Inversion Techniques
- Phytochemistry and Biological Activities
- Ecology and Conservation Studies
- Glaucoma and retinal disorders
- Natural Antidiabetic Agents Studies
- Bacteriophages and microbial interactions
- Bioactive natural compounds
- Animal Genetics and Reproduction
- Seismic Waves and Analysis
- Corneal surgery and disorders
- Plant Pathogenic Bacteria Studies
- Ginseng Biological Effects and Applications
- Cancer Research and Treatments
- Virus-based gene therapy research
- Reproductive Biology and Fertility
- Metabolism, Diabetes, and Cancer
- Food Quality and Safety Studies
- Acute Myocardial Infarction Research
Seoul National University
2016-2025
Korea University Medical Center
2015-2024
Inha University
2001-2024
Chungnam National University
2023-2024
National University College
2024
New Generation University College
2023-2024
Catholic University of Korea
2022-2024
Yeouido St. Mary's Hospital
2024
Hanmi Pharmaceutical (South Korea)
2023
Weatherford College
2022
Low-grade inflammation of the intestine results in metabolic dysfunction, which dysbiosis gut microbiota is intimately involved. Dietary fibre induces prebiotic effects that may restore imbalances microbiota; however, no clinical trials have been reported patients with diseases. Here, six obese subjects type 2 diabetes and/or hypertension were assigned to a strict vegetarian diet (SVD) for 1 month, and blood biomarkers glucose lipid metabolisms, faecal using 454-pyrosequencing 16S ribosomal...
Auditory fear memory is thought to be maintained by conditioning-induced potentiation of synaptic efficacy, which involves enhanced expression surface AMPA receptor (AMPAR) at excitatory synapses in the lateral amygdala (LA). Depotentiation, reversal potentiation, has been proposed as a cellular mechanism for extinction; however, direct link between depotentiation and extinction not yet tested. To address this issue, we applied both ex vivo approaches rats had consolidated. A unique form...
We have investigated the radioprotective efficacy of eckol, a component brown seaweed Ecklonia cava , against gamma ray‐induced damage in vivo. Our results showed that eckol significantly decreased mortality lethally irradiated mice. The mechanisms eckol's protection were found to include: an improvement hematopoietic recovery, repair damaged DNA immune cells and enhancement their proliferation, which had been severely suppressed by ionizing radiation. Thus, we propose as candidate for...
The integration of LC–MS/MS molecular networking and in silico MS/MS fragmentation is an emerging method for dereplication natural products. In the present study, a targeted isolation products using new silico-based annotation tool named Network Annotation Propagation (NAP) described. NAP improves accuracy analyses by reranking candidate structures based on network topology from MS/MS-based networking. spectral Sageratia theezans twig extract was performed NAP, most families within network,...
Itaconate, a crucial immunometabolite, plays critical role in linking immune and metabolic functions to influence host defense inflammation. Due its polar structure, the esterified cell-permeable derivatives of itaconate are being developed provide therapeutic opportunities infectious inflammatory diseases. Yet, it remains largely uncharacterized whether have potentials promoting host-directed therapeutics (HDT) against mycobacterial infections. Here, we report dimethyl (DMI) as promising...
Among half-Heusler alloys, MNiSn (M = Ti, Zr, Hf) compounds have been extensively investigated due to their unique crystal structure and promising thermoelectric properties. However, forming the single phase directly during solidification process is challenging, necessitating a prolonged annealing step for homogenization. Rapid Solidification Processing (RSP) was employed synthesize materials with controlled microstructures high performance within short processing time. Optimized RSP...
Abstract Objective To determine the efficacy of local therapy with human angiostatin gene in murine collagen‐induced arthritis (CIA). Methods DBA/1 mice were immunized bovine type II collagen. Before onset arthritis, NIH3T3 fibroblasts, transduced angiostatin‐expressing retroviral vectors or control vectors, transplanted into knee cavity. The incidence joints was evaluated histologically based on pannus formation and cartilage destruction. Paws macroscopically for redness, swelling,...
We present receptor-modified carbon nanotube sensors for the highly selective and sensitive detection of acetylcholine (ACh), one kind neurotransmitter. Here, we successfully expressed M1 muscarinic receptor (M1 mAChR), a family G protein-coupled receptors (GPCRs), in E. coli coated single-walled (swCNT)-field effect transistors (FETs) with lipid membrane including receptor, enabling ACh detection. Using this sensor, could detect at 100 pM concentration. Moreover, showed that sensor...
A Gram-positive bacterium, strain M-6-3(T), was isolated from salt-fermented seafood in Korea. The organism grew 0-10 % (w/v) NaCl and at 25-37 °C, with optimal growth occurring 5 28-30 °C. peptidoglycan type variation A4γ meso-diaminopimelic acid as the diagnostic cell-wall diamino acid. polar lipid profile of M-6-3(T) consisted diphosphatidylglycerol, phosphatidylglycerol, an unidentified phospholipid unknown glycolipid. Strain contained MK-7 major component quinone system anteiso-C(15 :...
A novel actinobacterium, strain P30 T , was isolated from jeotgal, a traditional Korean fermented seafood. Cells were aerobic, Gram-positive, non-motile and coccoid. Optimal growth occurred at 30–37 °C, pH 8–9 in the presence of 0–2 % (w/v) NaCl. Based on 16S rRNA gene sequence analysis, phylogenetically closely related to Kocuria carniphila gwangalliensis rhizophila marina rosea K. varians with levels similarity 98.6, 98.2, 98.1, 97.4, 97.3 %, respectively, type strains these species....
A novel, Gram-reaction-positive, aerobic, rod-shaped, non-motile bacterial strain, designated NAL101(T), was isolated from gajami-sikhae, a traditional Korean fermented seafood made of flatfish. Growth occurred at 4-45 °C, pH 5-10 and in 0-12 % (w/v) NaCl. Optimum growth 30-37 8 0-1 The cell-wall amino acids were 2,4-diaminobutyric acid, alanine, glycine, threonine glutamic acid the major fatty anteiso-C(15 : 0), iso-C(16 0) anteiso-C(17 0). predominant menaquinone MK-11. polar lipids...