A5100764546- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Aortic aneurysm repair treatments
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Optical Coherence Tomography Applications
- Pharmaceutical Economics and Policy
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Magnetic and transport properties of perovskites and related materials
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Structural Anomalies and Repair
- Cancer, Lipids, and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Infective Endocarditis Diagnosis and Management
Yonsei University
2016-2025
Severance Hospital
2016-2025
Gangnam Severance Hospital
2015-2024
Rural Development Administration
2004-2024
Yonsei University Health System
2015-2024
University Health System
2013-2024
Catholic University of Korea
2015-2024
Inje University
1999-2024
Hôpital Maison Blanche
2016-2024
Ewha Womans University
1995-2024
Use of intravascular ultrasound (IVUS) promotes better clinical outcomes for coronary intervention in complex lesions. However, randomized data demonstrating the usefulness IVUS are limited lesions treated with drug-eluting stents.To determine whether long-term IVUS-guided stent implantation superior to those angiography-guided patients long lesions.The Impact Intravascular Ultrasound Guidance on Outcomes Xience Prime Stents Long Lesions (IVUS-XPL) randomized, multicenter trial was conducted...
<h3>Importance</h3> Discontinuing aspirin after short-term dual antiplatelet therapy (DAPT) was evaluated as a bleeding reduction strategy. However, the strategy of ticagrelor monotherapy has not been exclusively in patients with acute coronary syndromes (ACS). <h3>Objective</h3> To determine whether switching to 3 months DAPT reduces net adverse clinical events compared ticagrelor-based 12-month ACS treated drug-eluting stents. <h3>Design, Setting, and Participants</h3> A randomized...
Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type diabetes (T2D); however, the underlying mechanism remains unclear. Activation of NLR family, pyrin domain-containing 3 (NLRP3) inflammasome and subsequent interleukin (IL)-1β release induces atherosclerosis heart failure. Here we show effect SGLT2 inhibitor empagliflozin on NLRP3 activity. Patients T2D high risk receive or sulfonylurea for 30 days, activation analyzed macrophages. While...
There have been no randomized studies comparing intravascular ultrasound (IVUS)-guided versus conventional angiography-guided chronic total occlusion (CTO) intervention using new-generation drug-eluting stent Therefore, we conducted a prospective, randomized, multicenter trial designed to test the hypothesis that IVUS-guided CTO is superior intervention.After successful guidewire crossing, 402 patients with CTOs were group (n=201) or and secondarily Resolute zotarolimus-eluting stents Nobori...
BACKGROUND: Stopping aspirin within 1 month after implantation of a drug-eluting stent for ticagrelor monotherapy has not been exclusively evaluated patients with acute coronary syndrome. The aim this study was to investigate whether <1 dual antiplatelet therapy (DAPT) is noninferior 12 months ticagrelor-based DAPT adverse cardiovascular and bleeding events in METHODS: In randomized, open-label, noninferiority trial, 2850 syndrome who underwent at 24 centers South Korea were randomly...
In patients with coronary artery disease, some guidelines recommend initial statin treatment high-intensity statins to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C). An alternative approach is begin moderate-intensity and titrate specific LDL-C goal. These alternatives have not been compared head-to-head clinical trial involving known disease.To assess whether treat-to-target strategy noninferior of for long-term outcomes disease.A randomized, multicenter,...
Abstract Background and Aims Drug-coated balloons (DCBs) have demonstrated favourable outcomes following endovascular therapy for femoropopliteal artery (FPA) disease. However, uncertainty remains whether the use of intravascular ultrasound (IVUS) can improve DCBs. Methods This prospective, multicentre, randomized trial, conducted at seven centres in South Korea, compared IVUS-guided vs. angiography-guided angioplasty treating FPA disease with Patients were assigned to receive (n = 119) or...
PURPOSE: To retrospectively evaluate criteria for differentiating extrahepatic bile duct cholangiocarcinoma from benign cause of stricture at magnetic resonance cholangiopancreatography (MRCP) and to compare diagnostic accuracy with this modality versus endoscopic retrograde (ERCP). MATERIALS AND METHODS: MRCP ERCP images in 50 patients (27 [18 men, nine women; mean age, 58 years] 23 [13 10 60 years]) were reviewed assess the appearance strictures. Final diagnosis was based on surgical or...
<h3>Objective</h3> To investigate the long-term prognostic implications of contrast-induced acute kidney injury (CI-AKI) with transient or persistent renal dysfunction in myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). <h3>Design</h3> A retrospective observational registry study. <h3>Setting</h3> Clinical follow-up after PCI. <h3>Patients and methods</h3> total 1041 PCI-treated AMI from Infarction Prognosis Study registry. CI-AKI was defined as an...
Background— We sought to investigate the mechanism of geometric changes after main branch (MB) stent implantation and identify predictors functionally significant “jailed” side (SB) lesions. Methods Results— Seventy-seven patients with bifurcation lesions were prospectively enrolled from 8 centers. MB intravascular ultrasound was performed before implantation, fractional flow reserve measured in jailed SB. The vessel volume index both proximal distal increased implantation. plaque decreased...
Oculodentodigital dysplasia (ODDD) is a dominant negatively inherited disorder with variable but characteristic anomalies of the fingers and toes, eyes, face teeth, which are caused by mutations in connexin 43 (Cx43) gene. All analyzed so far have negative influence on conductance through gap junctional channels hemichannels, as well trafficking Cx43 protein transfected cells. In this study, we inserted human Cx43G138R point mutation into mouse gene generated mice conditionally expressing...
Background— We investigated the incidences, predictors, and clinical outcomes of acute late stent malapposition detected by optical coherence tomography (OCT) after drug-eluting implantation. Methods Results— analyzed OCT images from 351 patients with 356 lesions who received poststent follow-up examinations. Acute was observed in 62% lesions. Approximately half malappositions were located within edges stents. Severe diameter stenosis, calcified lesions, long stents independent predictors...
Background Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. and villitis unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection another type transplantation We investigated whether there was evidence for antibody-mediated against the fetus birth. Methods Findings This cross-sectional study included women with (1) normal pregnancy term delivery (n = 140) (2) 140). analyzed fetal sera panel-reactive anti-HLA class I...