A5031603695- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac tumors and thrombi
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Cardiovascular and Diving-Related Complications
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pancreatic function and diabetes
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Coronary Artery Anomalies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Sodium Intake and Health
- Optical Coherence Tomography Applications
- Pituitary Gland Disorders and Treatments
Severance Hospital
2018-2025
Yonsei University
2017-2025
The Heart House
2024
Inha University Hospital
2020
Wonju Severance Christian Hospital
2020
Yonsei University Health System
2017
Inha University
2013-2015
We sought to investigate an anti-atherosclerotic and anti-inflammatory effect of sodium-glucose cotransporter-2 (SGLT-2) inhibitors in normoglycemic atherosclerotic rabbit model.Male New Zealand white rabbits (n=26) were fed with a 1% high-cholesterol diet for 7 weeks followed by normal 2 weeks. After balloon catheter injury, the administered Dapagliflozin (1mg/kg/day) or control-medium 8 (n=13 each group). All lesions assessed angiography, optical coherence tomography (OCT), histological...
Recent studies have reported improved diastolic function in patients administered sodium-glucose cotransporter 2 inhibitors (SGLT2i). We aimed to investigate the effect of dapagliflozin on left ventricular (LV) a diabetic animal model and determine molecular cellular mechanisms underlying its function.A total 30 male New Zealand white rabbits were randomized into control, diabetes, or diabetes+dapagliflozin groups (n = 10/per each group). Diabetes was induced by intravenous alloxan. Cardiac...
There are few randomised studies concerning the optimal duration of dual antiplatelet therapy (DAPT) for patients who receive a second-generation drug-eluting stent (DES). This trial aimed to investigate safety six-month compared with 12-month DAPT maintenance after DES implantation.A prospective, randomised, multicentre was performed at 10 medical centres. The 1,368 included in study received biolimus-eluting (BES) or zotarolimus-eluting (ZES). primary outcome measured composite major...
Abstract Recently, coronary angiography (CAG) and percutaneous intervention (PCI) via the distal radial access (DRA), are gaining attention owing to fewer complications. Despite advantages of DRA, there is difficulty initiate this new vascular approach. The data from 1000 patients who underwent CAG PCI DRA by a single experienced operator were retrospectively analyzed. primary outcome was success rate per 100 cases. Moreover, predictors failed Overall, 952 (95.2%) total 1,000 successful DRA....
Objective Left atrial appendage (LAA) thrombus has heretofore been considered a contraindication to percutaneous LAA closure (LAAC). Data regarding its management are very limited. The aim of this study was analyse the medical and invasive treatment patients referred for LAAC in presence thrombus. Methods This multicentre observational registry included 126 consecutive with on preprocedural imaging. Treatment strategies intensification antithrombotic therapy (IAT) or direct LAAC. primary...
Although socioeconomic status (SES) is considered a risk factor for cardio-cerebrovascular diseases (CCVDs), few studies have examined this association. In cross-sectional study, we aimed to assess the prevalence and trends of CCVDs across different SES groups over 12-year period in representative Korean population.
Diastolic hyperemia-free ratio (DFR), an alternative to fractional flow reserve (FFR) for the assessment of intermediate coronary artery stenosis, helps reduce patients' time, and inconvenience. However, validation data DFR FFR are lacking. We aimed evaluate diagnostic accuracy assess effective decision making revascularization using their values. Patients subjected invasive physiological study stenosis at a single center in South Korea between August 2022 January 2024 were prospectively...
Data on the interactions between clopidogrel and tegoprazan are limited. We compared effects of proton-pump inhibitors (PPIs) platelet reactivity. Using database data from March 2020 to January 2023, we retrospectively evaluated 262 patients who were taking either (n = 107) or PPIs 155) combined with dual antiplatelet therapy, including aspirin clopidogrel, after percutaneous coronary intervention. Platelet reactivity was assessed using VerifyNow P2Y12 assays. reaction unit (PRU) values at 3...
Abstract Background There is a lack of data regarding outcomes therapeutic hypothermia in patients with acute myocardial infarction (AMI) complicated by out-of-hospital cardiac arrest (OHCA). This study aimed to evaluate the effect on clinical comatose after percutaneous coronary intervention (PCI) for AMI following OHCA. Methods Using prospective nationwide registry from 2016 2021, we selected 2925 who underwent emergency PCI among 182,508 OHCA cases. These were divided into groups...
Background We investigated the sex‐specific variations in distal radial access (DRA)–associated outcomes, as well factors influencing these by utilizing a comprehensive real‐world registry. Methods In this post‐hoc analysis of KODRA (Korean Prospective Registry for Evaluating Safety and Efficacy Distal Radial Approach) trial, we selected 4608 patients who underwent successful coronary procedures, including percutaneous intervention or angiography, via DRA. Primary end points were overall DRA...
Microvascular invasion (MVI) is a well-known prognostic factor of postoperative recurrence and overall survival (OS) in patients with hepatocellular carcinoma (HCC). We compared the treatment outcomes transarterial chemoembolization (TACE) surgery/radiofrequency ablation (RFA) according to presence MVI early or late recurrent HCC that presented as Barcelona Clinical Liver Cancer (BCLC) stage 0 A after curative resection for HCC.A consecutive 68 BCLC at our institution between 1998 2012 were...
The composite summary score (range, 0-24) of abdominal aortic calcification (AAC) devised by Kauppila et al is a simple method assessing AAC severity. However, few studies have been conducted to determine an optimal cutoff for the prediction mortality or investigate relation between mineral metabolism and progression using scoring system.The medical records 112 patients on hemodialysis who had undergone lateral lumbar radiography every 6 months from August 2009 were reviewed. Patients...
Aim Although the atheroprotective effects of statins and angiotensin II receptor blockers (ARBs) are well-established, little is known about their additive effects, especially during early period atherosclerosis. The aim this study was to investigate whether combination a statin an ARB exerts synergistic anti-atherosclerotic elucidate mechanisms combined effects. Methods Atherosclerotic plaques were developed in arteries 23 rabbits using high-cholesterol diet (HCD) intra-arterial balloon...
Abstract The complex structure of the left atrial appendage (LAA) brings limitations to two-dimensional-based LAA occlusion (LAAO) size prediction system using transesophageal echocardiography. anatomy can be evaluated more precisely three-dimensional images from cardiac computed tomography (CT); however, there is lack data regarding which parameter choose CT-based during pre-procedural planning LAAO. We aimed assess accuracy measurements derived CT for selecting LAAO devices....
The distal radial approach (DRA) for coronary catheterization is increasingly being used worldwide yet the optimal medication regimen to prevent artery spasm (RAS), an important factor success of procedure, remains unclear. aim this study examine effectiveness preventing RAS via DRA.This was a prospective, comparative randomized including 400 patients who underwent DRA in single center by three experienced operators. Patients were either nitroglycerin (NTG) injection (N = 200) or NTG plus...
Background Continuing antiplatelet therapy (APT) has been generally recommended during noncardiac surgery, but it is uncertain if preoperative discontinuation of APT avoided or harmful in patients with second-generation drug-eluting coronary stents. Methods and Results Patients undergoing surgery after stent implantation were assessed a multicenter cohort Korea. Net adverse clinical events within 30 days postoperatively, defined as all-cause death, major cardiac events, bleeding, evaluated....
Background/Aims: Achieving rapid reduction of low-density lipoprotein cholesterol (LDL-C) levels below 55 mg/dL in patients with acute myocardial infarction (AMI) can be challenging statins alone. This single-center, retrospective study aimed to assess the impact single-dose injection evolocumab 140 mg on LDL-C during peri-percutaneous coronary intervention (PCI) period AMI.Methods: A total 95 AMI who underwent PCI were divided into (n = 50) and non-evolocumab 45) groups.Results: The...
The distal radial access (DRA), a potential alternative to the trans-radial approach (TRA), may offer advantages in terms of site complications due its smaller vessel diameter, especially for high bleeding risk (HBR) patients. This study aims investigate feasibility DRA HBR