A5100406465- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis Viruses Studies and Epidemiology
- Biliary and Gastrointestinal Fistulas
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Protein Hydrolysis and Bioactive Peptides
- Systemic Lupus Erythematosus Research
- Alcohol Consumption and Health Effects
- Pancreatic and Hepatic Oncology Research
- HIV/AIDS drug development and treatment
- Viral gastroenteritis research and epidemiology
- Liver physiology and pathology
- Nutrition and Health in Aging
- Gastrointestinal Bleeding Diagnosis and Treatment
- Travel-related health issues
- Cancer, Lipids, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Wastewater Treatment and Nitrogen Removal
Seoul National University
2022-2024
Inha University Hospital
2014-2024
Inha University
2012-2022
Korean Cancer Study Group
2016-2021
Weatherford College
2021
Incheon Medical Center
2020
Korea University
2002-2019
Ministry of Health and Welfare
2019
Specim (Finland)
2016
Kyung Hee University
2005-2014
Eltrombopag is an oral thrombopoietin-receptor agonist. This study evaluated the efficacy of eltrombopag for increasing platelet counts and reducing need transfusions in patients with thrombocytopenia chronic liver disease who are undergoing elective invasive procedure.
Evidence collectionThe committee systematically collected and reviewed the international domestic literature published in PubMed, MEDLINE, KoreaMed, other databases.The was limited to research papers English Korean languages.The keywords used were 'nonalcoholic fatty liver disease,' liver,' steatohepatitis,' 'fatty 'hepatic steatosis,' 'steatohepatitis.'In addition, related specific clinical questions included. Levels of evidence grades recommendationsThe gathered for data collection...
Summary Background Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) account for an increasing proportion of in the Asia‐Pacific region. Many areas region are experiencing epidemics metabolic syndrome among rapidly ageing populations. Aims To estimate using modelling growth NAFLD populations, including cases with significant fibrosis that most likely to experience advanced related mortality. Methods A progression model was used summarise project populations...
Non-alcoholic steatohepatitis (NASH) is characterized by hepatocellular injury and initial fibrosis severity has been suggested as an important prognostic factor of NASH. Silymarin was reported to improve carbon tetrachloride-induced liver reduce the activation hepatic stellate cells (HSC). We investigated whether silymarin could suppress HSCs in NASH induced methionine- choline-deficient (MCD) diet fed insulin-resistant rats. feeding MCD obese diabetic Otsuka Long-Evans Tokushima Fatty...
<h3>Background</h3> Besifovir (LB80380) is an acyclic nucleotide phosphonate effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic (CHB) patients preliminary studies. <h3>Design</h3> We aimed to compare the safety antiviral activity of two doses besifovir (90 mg 150 daily) with entecavir 0.5 daily CHB patients. 114 were randomised receive 90 (n=36), (n=39) or (n=39). HBV liver biochemistry, including serum L-carnitine levels,...
Accurate assessment of hepatocellular carcinoma (HCC) risk in chronic hepatitis B (CHB) patients receiving entecavir (ETV)/tenofovir disoproxil fumarate (TDF) is likely to play a pivotal role post-treatment follow-up strategy. We aimed develop simple and reliable predictive model for HCC these patients.A database 1242 consecutive treatment-naive CHB who initially underwent ETV/TDF between February 2007 January 2017 at four referral hospitals South Korea was analyzed. The constructed on the...
Summary Background Anti‐viral therapy is not indicated for patients with chronic hepatitis B (CHB) in the immune‐tolerant phase. Aims To investigate cumulative incidence of phase change and hepatocellular carcinoma (HCC) independent predictors CHB Methods In total, 946 phase, defined as e antigen positivity, HBV‐DNA >20 000 IU/mL alanine aminotransferase (ALT) ≤40 IU/L, between 1989 2017 were enrolled from eight institutes. Results The mean age study population (429 men 517 women) was...
Abstract Purpose: Transcriptional profiling showed decreased expression of gastrokine 1 (GKN1) and the related trefoil factor interacting protein (TFIZ1/GKN2) in Helicobacter pylori infection. Decreased GKN1 GKN2 mRNA has been reported gastric adenocarcinoma. We have examined a large cancer series, correlated with tumor subtype, evaluated their utility as prognostic biomarkers. Experimental Design: GKN1, GKN2, factors TFF1 TFF3 were tissue microarrays from 155 distal adenocarcinomas....
Background/Aims: Bacterial infection is accepted as a precipitating factor in cholesterol gallstone formation, and recent studies have revealed the presence of Helicobacter species hepatobiliary system.We utilized polymerase chain reaction (PCR) to establish bacterial DNA, including from species, gallstones, bile juice, gallbladder mucosa patients with gallstones.Methods: At cholecystectomy, 58 48 samples, 46 specimens were obtained subjected nested PCR using specific 16S rRNA primers H....
We compared the post-treatment overall survival (OS) and recurrence-free (RFS) between patients with Child-Turcotte-Pugh (CTP) class-A single small (≤3 cm) hepatocellular carcinoma (HCC) treated by surgical resection (SR) radiofrequency ablation (RFA).We retrospectively analyzed 391 HCC CTP who underwent SR (n=232) or RFA (n=159) as first-line therapy for HCC. Survival was according to tumor size (≤2 cm/2-3 presence of cirrhosis. Inverse probability treatment weighting (IPW) method used...
Microvascular invasion (MVI) is a well-known prognostic factor of postoperative recurrence and overall survival (OS) in patients with hepatocellular carcinoma (HCC). We compared the treatment outcomes transarterial chemoembolization (TACE) surgery/radiofrequency ablation (RFA) according to presence MVI early or late recurrent HCC that presented as Barcelona Clinical Liver Cancer (BCLC) stage 0 A after curative resection for HCC.A consecutive 68 BCLC at our institution between 1998 2012 were...
Abstract Background Gastrointestinal tumor bleeding remains a clinical challenge because it is difficult to treat with conventional endoscopic hemostatic options. Recently, an powder (UI-EWD) was developed and reported provide effective control of upper gastrointestinal bleeding. The aim current study evaluate the feasibility efficacy this novel in Methods A total 41 consecutive patients were included. UI-EWD applied all as auxiliary method salvage therapy or monotherapy during treatment....
BackgroundIt is unclear whether direct-acting antivirals (DAAs) treatment improves the disease burden in hepatitis C virus (HCV) infection. This study aimed to investigate effect of DAA on reduction patients with HCV infection using individual participant data.MethodsThis nationwide multicentre retrospective cohort recruited from 29 tertiary institutions South Korea. The data collection was done medical records each institution. included untreated and DAAs-treated excluded those a history...
Risk Factors for Long-term Outcomes after Initial Treatment in HepatolithiasisHepatobiliary complications, such as stone recurrence, recurrent cholangitis, liver abscess, secondary biliary cirrhosis, and cholangiocarcinoma may occur treatment hepatolithiasis.However, few previous studies have addressed the risk factors longterm outcomes initial treatment.Eighty-five patients with newly diagnosed hepatolithiasis, actively treated constituted cohort of this retrospective study.Patients were by...
Abstract Telomere length has been linked to the prevalence and progression of metabolic disease. However, clinical implications telomere in biopsy-proven non-alcoholic fatty liver disease (NAFLD) patients remain unclear. Therefore, this study aimed investigate association with histological severity NAFLD. The cross-sectional data derived from prospectively enrolled Boramae NAFLD registry (n = 91) were analyzed. tissues information obtained both non-NAFLD subjects. Binary logistic regression...
Abstract The microbial community composition and dominant denitrifying populations in high-nitrate-removing (CR-I) low-nitrate-removing (CR-II) activated sludge from continuous bioreactors were investigated with most probable number (MPN) enumeration, fluorescence situ hybridization (FISH) 16S rDNA characterization. MPNs of nitrate-reducing bacteria CR-I CR-II 2.82x10(7) 2.69x10(4) colony-forming units ml(-1), respectively. Eight two isolated CR-I, four three CR-II. Small subunit...
Aim We aimed to identify the incidence rate of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients treated with entecavir or tenofovir South Korea, and predictors HCC development these patients. Methods Between January 2007 December 2015, 582 CHB initially received ( n = 406, 69.8%) 176, 30.2%) for CHB. Results During a median follow‐up 57.1 months, developed 38 (6.5%) patients, regardless antiviral agent type. Entecavir‐ tenofovir‐treated had similar rates P 0.471). For 2‐,...