A5088767279- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Hepatitis Viruses Studies and Epidemiology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Circular RNAs in diseases
- HIV/AIDS drug development and treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Alcohol Consumption and Health Effects
- Multiple and Secondary Primary Cancers
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Brain Tumor Detection and Classification
- Lung Cancer Treatments and Mutations
- Bone and Dental Protein Studies
Korea University
2014-2025
Korea University Medical Center
2014-2022
Ansan University
2014-2019
Christie's
2016
Jeil Pharmaceutical (South Korea)
2016
Ministry of Health and Welfare
2016
Creative Commons
2016
Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic disease, but the exact mechanism progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown. Here, we investigated role exosomes in NAFLD progression. Exosomes were isolated human hepatoma cell line treated with palmitic acid (PA) and their miRNA profiles examined by microarray. The hepatic stellate (HSC) (LX-2) was then exosome hepatocytes. Compared controls, PA-treated hepatocytes...
AIMTo investigate the factors affecting diagnostic delay and outcomes of in inflammatory bowel disease (IBD) METHODSWe retrospectively studied 165 patients with Crohn's (CD) 130 ulcerative colitis (UC) who were diagnosed had follow up durations > 6 mo at Korea University Ansan Hospital from
Transient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB CHC).From April 2006 June 2014, 916 (567 CHB 349 CHC) who underwent LB at 15 centres were analyzed. The Batts Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)-to-platelet ratio indexes (APRI) calculated. Area under receiver operating...
Summary Background Anti‐viral therapy is not indicated for patients with chronic hepatitis B (CHB) in the immune‐tolerant phase. Aims To investigate cumulative incidence of phase change and hepatocellular carcinoma (HCC) independent predictors CHB Methods In total, 946 phase, defined as e antigen positivity, HBV‐DNA >20 000 IU/mL alanine aminotransferase (ALT) ≤40 IU/L, between 1989 2017 were enrolled from eight institutes. Results The mean age study population (429 men 517 women) was...
Background The prognostic performance of the albumin‐bilirubin (ALBI) grade in hepatocellular carcinoma (HCC) as an objective method assessing liver function was investigated. Methods Data from 2099 patients with HCC Korea were collected and analyzed retrospectively. discriminative ALBI compared Child‐Pugh (C‐P) for different stages or treatments. Results median follow up duration 16.2 months (range: 1.0‐124.9). survival times 49.7 C‐P A (65.8%), 12.4 B (25.5%), 4.2 C (8.6%) ( P < 0.001)....
Sorafenib is the first approved systemic treatment for advanced hepatocellular carcinoma (HCC). However, its clinical utility limited, especially in Asian countries. Several reports have suggested survival benefits of hepatic arterial infusion chemotherapy (HAIC) HCC with main portal vein tumor thrombosis (PVTT). This study aimed to compare efficacy sorafenib-based therapy that HAIC-based PVTT.Advanced patients PVTT treated sorafenib or HAIC between 2008 and 2016 at Korea University Medical...
For the treatment of spontaneous bacterial peritonitis (SBP), cefotaxime, ceftriaxone, and ciprofloxacin were used as first-line agents. However, considering increasing rate antibiotic resistance, it is unclear which these drugs can be initially recommended. This study aimed to compare current efficacy 3 antibiotics, namely ciprofloxacin, for SBP in patients with cirrhosis ascites, when guided by therapeutic responses.This was a multicenter, prospective, randomized controlled trial. The...
Entecavir (ETV) may have limited antiviral efficacy in chronic hepatitis B (CHB) patients with a high baseline viral load, especially cases of partial virologic response (PVR). This study evaluated the outcomes prolonged ETV monotherapy, given lack clear evidence favoring continuation or combination therapy such scenarios. We included 188 treatment-naïve on 0.5 mg and compared responses between load (HVL, ≥7 log10 IU/mL) non-HVL groups for over up to 120 months this study. Compared group,...
α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that reportedly associated with tumorigenesis metastasis. This study was conducted evaluate clinical utility of using plasma GPC3 OPN as biomarkers for HCC.We measured levels in 120 HCC 40 chronic liver disease (CLD) patients via an enzyme-linked immunosorbent assay. The accuracy each...
Although the Barcelona Clinic Liver Cancer (BCLC) staging system is widely used for hepatocellular carcinoma (HCC) staging, most appropriate BCLC stage designation single large HCC (SLHCC, nodule > 5 cm) remains controversial. This study investigated prognosis of patients with SLHCC.Patients newly diagnosed HCCs (BCLC stages A or B) were classified according to tumor burden: group 1, a 2 and ≤ cm two three nodules 3 cm; 2, 3, nodules. Survival analysis was performed stage, treatment type,...
The prognostic role of aberrant serum miRNA expression for predicting response to sorafenib treatment in advanced hepatocellular carcinoma (HCC) patients has not been well characterized.We aimed identify specific miRNAs that are associated with positive radiologic responses or improved survival sorafenib-treated HCC patients.miR-18a, miR-21, miR-139-5p, miR-221, miR-224, and miR-10b-3p, were selected analysis.Serum samples from 24 stage 25 liver cirrhosis (LC) analyzed.All the except miR-21...
Endoscopic variceal band ligation (EVL) is an effective procedure to control and prevent bleeding in patients with liver cirrhosis, but it can be complicated by from post-EVL ulcers. Several studies have reported that proton pump inhibitors (PPIs) decrease the size of However, evidence are limited as whether PPIs actually reduce risk after EVL. This study aimed analyze factors associated prophylactic EVL assess effect PPI therapy. Five hundred five cirrhotic high esophageal varices who...
A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients chronic hepatitis B (CHB). We investigated whether the achievement sc-LS antiviral therapy (AVT) reduced risk developing hepatocellular carcinoma (HCC) CHB-related advanced fibrosis or cirrhosis.In total, 209 cirrhosis, who received paired elastography examinations during AVT between 2007 and 2012, were enrolled. The cut-off LS value for ultrasonographic...
Background/Aims In patients with liver cirrhosis, drugs acting on the central nervous system can lead to hepatic encephalopathy and effects may be prolonged. Recently, misuse of propofol has been reported associated risk death have become an issue. Propofol is commonly used during sedative endoscopy; therefore, its safety in high-risk groups must further investigated. We performed a pilot study efficacy endoscopy Korean cirrhosis. Methods Upper gastrointestinal was under sedation along...
For the prevention of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites, norfloxacin 400 mg per day is recommended as a standard regimen. This study aims to investigate whether ciprofloxacin once weekly administration not inferior daily for SBP.This an investigator-initiated open-label randomized controlled trial conducted at seven tertiary hospitals South Korea. Liver cirrhosis ascites were screened, and enrolled this if ascitic protein ≤1.5 g/dL or presence history...
Clear indicators for stopping antiviral therapy in chronic hepatitis B (CHB) patients are not yet available. Since the level of surface antigen (HBsAg) is correlated with covalently closed circular DNA, HBsAg titer might be a good indicator off-treatment response. This study aimed to determine relationship between and entecavir (ETV) analyzed 44 consecutive CHB (age, 44.6±11.4 years, mean±SD; men, 63.6%; positive envelope (HBeAg) at baseline, 56.8%; HBV DNA level, 6.8±1.3 log10 IU/mL)...
Entecavir 0.5 mg (ETV) is widely used among treatment-naïve chronic hepatitis B (CHB) patients. However, 10%-30% of patients show partial virologic response (PVR) to the drug. If virus (HBV) continues replicate, underlying liver disease may progress. Herein, we compared efficacy switching tenofovir disoproxil fumarate (TDF) with that continuing ETV in CHB PVR ETV. This was an open-label randomized controlled trial including who had been receiving for >12 months, but still detectable HBV DNA...
Necrotizing pancreatitis is one of the rare complications transcatheter arterial chemoembolization (TACE). after TACE may result from development ischemia caused by regurgitation embolic materials into vessels supplying pancreas. We report a case post-TACE necrotizing with abscess formation in patient hepatocellular carcinoma. The had suffered hepatic artery injury due to repetitive TACE; during his 25th procedure he submitted selective catheterization feeding vessel dorsal pancreatic...
Entecavir (ETV) induces biochemical and histologic improvement of the liver in patients with chronic hepatitis B. This study aimed to confirm that 2 years ETV treatment improves function non-invasive fibrosis markers B virus (HBV)-associated cirrhosis.A total 472 naïve HBV-associated cirrhosis was treated for at least years, between March 2007 December 2012. Model end-stage disease Child-Pugh (CP) score were used evaluate function. Aspartate transaminase platelet ratio index, FIB-4 index...
The goal of the study was to compare efficacy and safety sorafenib with those systemic cytotoxic chemotherapy.Sorafenib treatment has shown improve survival in patients advanced hepatocellular carcinoma (HCC) when compared placebo. However, whether controls advanced-stage HCC better than chemotherapy not been elucidated.We retrospectively reviewed medical records 220 measurable who had received previously between January 2007 April 2012. Among these patients, 78 treated sorafenib. Another 14...
Background/Aims: In addition to the globally endorsed Barcelona Clinic Liver Cancer (BCLC) staging system, other algorithms or systems have been developed, including Hong Kong (HKLC) system.This study aimed validate HKLC system relative BCLC for predicting survival hepatocellular carcinoma (HCC) patients in Korea.Methods: From 2004 2013, 2,571 newly diagnosed with HCC were consecutively enrolled at three Korea University medical centers.Results: Both differentiated well (p<0.001).However,...