A5036816797- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Gastric Cancer Management and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Cancer Mechanisms and Therapy
- Renal cell carcinoma treatment
- HIV/AIDS drug development and treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Amoebic Infections and Treatments
- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- Inflammatory Bowel Disease
Soonchunhyang University Hospital
2016-2025
Soonchunhyang University
2016-2025
CHA Bundang Medical Center
2021-2024
CHA University
2021-2024
Kyung Hee University
2006-2024
Korea University of Technology and Education
2023-2024
Digestive Health Research Institute
2010-2023
Bucheon University
2015-2023
Kyungpook National University
2016-2022
Yeungnam University
2022
Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has been suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous BM-MSC in the treatment alcoholic cirrhosis were investigated. Seventy-two patients with baseline biopsy-proven who had alcohol-abstinent more than 6 months underwent a multicenter, randomized, open-label, phase 2 trial. Patients randomly assigned to three groups: one control group two groups that either one-time or two-time...
Significance N6 -methyladenosine (m 6 A) has recently been found to regulate numerous aspects of RNA biology. Similar methylation cytosine residues in DNA, eukaryotic is modified by enzymatic addition methyl groups at adenosines. m A modification affects a wide variety functions, including mRNA stability, translation, and the case viruses, viral replication production. Our investigation revealed that adenosine present known consensus motif within 5′ epsilon stem loop pregenomic 3′ ends all...
Laparoscopic and robotic techniques have both been well adopted as safe options in selected patients undergoing hepatectomy. However, it is unknown whether either approach superior, especially for major hepatectomy such right or extended (RH/ERH).To compare the outcomes of vs laparoscopic RH/ERH.In this case-control study, propensity score matching analysis was performed to minimize selection bias. Patients RH/EHR at 29 international centers from 2008 2020 were included.Robotic RH/ERH.Data...
Alpha-fetoprotein (AFP), Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for the diagnosis hepatocellular carcinoma (HCC). This study compared diagnostic values AFP, AFP-L3, PIVKA-II individually in combination to find best biomarker panel. Seventy-nine patients with newly diagnosed HCC 77 non-HCC control liver cirrhosis were enrolled. measured same serum samples using microchip...
Table 1.Grading evidence and recommendations Evidence Notes High quality Further research is very unlikely to change our confidence in the estimate of effect A Moderate likely have an important impact on may B Low estimate.Any uncertain C Recommendation Strong Factors influencing strength recommendation included evidence, presumed patient-important outcomes, cost 1 Weak Variability preferences values, or more uncertainty.Recommendation made with less certainty, higher resource consumption 2
Background/Aims: Direct-acting antivirals (DAAs) effectively eradicate hepatitis C virus (HCV).This study investigated whether metabolic dysfunction influences the likelihood of fibrosis regression after DAA treatment in patients with chronic (CHC).Methods: This multicenter, retrospective included 8,819 diagnosed CHC who were treated DAAs and achieved a sustained virological response (SVR) between January 2014 December 2022.Fibrosis was defined as 20% reduction noninvasive surrogates for...
The reported durability of virologic response after successful lamivudine monotherapy is variable, and the question remains as to whether responses can be maintained over an extended follow-up period. aim this study was investigate posttreatment durability, optimal duration additional treatment HBeAg clearance or seroconversion, determinants for sustained (SVR) following in patients with HBeAg-positive chronic hepatitis B (CHB). From January 1999 August 2004, 178 Korean CHB were treated...
Difficult diagnoses and a lack of effective therapy complicate biliary tract malignancies. Interleukin-6 (IL-6) is human bile duct epithelium growth factor correlated with tumor burden. We evaluated the usefulness serum IL-6 in diagnosis primary BDC measured changes levels following photodynamic (PDT).We prospectively patients (N = 26: 14 treated PDT, 12 drainage alone), hepatocelluar carcinoma (HCC, N 26), healthy adults 23). Serum were by an enzyme-linked immunosorbent assay. Patients...
Background/aims The accuracy of noninvasive markers to discriminate nonalcoholic steatohepatitis (NASH) is unsatisfactory. We investigated whether transient elastography (TE) could patients with NASH from those fatty liver disease (NAFLD). Methods suspected NAFLD who underwent biopsy and concomitant TE were recruited five tertiary centers between November 2011 December 2013. Results study population (n = 183) exhibited a mean age 40.6 years male predominance 111, 60.7%). Of the participants,...
We investigated the effects of sorafenib monotherapy on advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) in a clinical setting.In total, 143 consecutive patients with unresectable HCC were treated sorafenib. Among these patients, 30 PVTT (Vp3 or 4) monotherapy.All had performance status 1 to 2 (Eastern Cooperative Oncology Group 1/2, 20/10) Child-Pugh class A B (A/B, 17/13). Eleven modified Union for International Cancer Control stage IVA tumors, whereas 19 IVB...
Transient elastography (TE) has become an alternative to liver biopsy (LB). This study investigated the diagnostic performance of stiffness (LS) measurement using TE in Korean patients with chronic hepatitis B and C (CHB CHC).From April 2006 June 2014, 916 (567 CHB 349 CHC) who underwent LB at 15 centres were analyzed. The Batts Ludwig scoring system was used for histologic assessment. Aspartate aminotransferase (AST)-to-platelet ratio indexes (APRI) calculated. Area under receiver operating...
To investigate the predictive factors for complete response (CR) and recurrence after CR in patients with hepatocellular carcinoma (HCC) treated transarterial chemoembolization (TACE).Among 691 newly diagnosed HCC patients, 287 were TACE as a first therapy. We analyzed CR, overall survival (OS).Eighty-one (28.2%) achieved TACE, was detected 35 (43.2%). In multivariate analyses, tumor size (≤5 cm) single nodularity hazard ratios (HRs) of 0.35 (p=0.002) 0.41 (p<0.001), respectively. Elevated...
Colonic mucosal defects might be a route for bacterial invasion into the portal system, with subsequent hematogenous spread to liver. We retrospectively investigated results of colonoscopy and clinical characteristics patients pyogenic liver abscess colonic origin.A total 230 consecutive were reviewed between 2003 2010. The categorized three groups (pancreatobiliary [n = 135], cryptogenic 81], others 14]). Of 81 patients, 37 (45.7%) underwent colonoscopy. lesions considered causes abscess.In...
Background & Aim To investigate the prevalence, mortalities, and patient characteristics of Acute-on-chronic liver failure (ACLF) according to AARC (Asian Pacific Association for Study Liver ACLF Research Consortium) European CLIF-C (Chronic Failure definitions. Methods We collected retrospective data 1470 hospitalized patients with chronic disease (CLD) acute deterioration between January 2013 December from 21 university hospitals in Korea. Results Of assessed, prevalence based on...
Rhus verniciflua is commonly known as a lacquer tree in Korea. The bark of R. has been used an immunostimulator traditional medicine, but also causes allergic dermatitis due to urushiol derivatives. For the development active natural resources with less toxicity, antibacterial activity various parts such bark, lignum, leaves and fruit, together chemical composition, were investigated. Among verniciflua, lignum showed most potent against fish pathogenic bacteria Edwardsiella tarda, Vibrio...
Hepatitis C virus (HCV) alters mitochondrial dynamics associated with persistent viral infection and suppression of innate immunity. Mitochondrial dysfunction is also a pathologic feature direct-acting antiviral (DAA) treatment. Despite the high efficacy DAAs, their use in treating patients chronic hepatitis interferon-sparing regimens occasionally produces undesirable side effects such as fatigue, migraine, other conditions, which may be linked to dysfunction. Here, we show that clinically...