A5010914670- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Innovation in Digital Healthcare Systems
- Hepatitis B Virus Studies
- Cancer-related gene regulation
- Hepatitis C virus research
- Internet of Things and Social Network Interactions
- Video Surveillance and Tracking Methods
- Viral-associated cancers and disorders
- IPv6, Mobility, Handover, Networks, Security
- Face recognition and analysis
- User Authentication and Security Systems
- Plant Disease Resistance and Genetics
- Photosynthetic Processes and Mechanisms
- Biometric Identification and Security
- Plant pathogens and resistance mechanisms
- HVDC Systems and Fault Protection
- Diverse Approaches in Healthcare and Education Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Plant Molecular Biology Research
- Antioxidant Activity and Oxidative Stress
- RNA and protein synthesis mechanisms
- Genetic and Environmental Crop Studies
Kookmin University
2024-2025
Electronics and Telecommunications Research Institute
2002-2024
Seoul National University
2019-2024
University of California, San Diego
2020-2024
Chungnam National University
2022-2024
Kangwon National University
2024
GTx (United States)
2024
Asan Medical Center
2024
University of Ulsan
2024
Ulsan College
2024
Significance N6 -methyladenosine (m 6 A) has recently been found to regulate numerous aspects of RNA biology. Similar methylation cytosine residues in DNA, eukaryotic is modified by enzymatic addition methyl groups at adenosines. m A modification affects a wide variety functions, including mRNA stability, translation, and the case viruses, viral replication production. Our investigation revealed that adenosine present known consensus motif within 5′ epsilon stem loop pregenomic 3′ ends all...
Background and Aims Epitranscriptomic modification of RNA has emerged as the most prevalent form regulation gene expression that affects development, differentiation, metabolism, viral infections, notably cancer. We have previously shown hepatitis B virus (HBV) transcripts are modified by N6 methyladenosine (m 6 A) addition. HBV also m A several host RNAs, including phosphatase tensin homolog (PTEN), a well‐known tumor suppressor. PTEN plays critical role in antiviral innate immunity...
N6-Methyladenosine (m6A), the methylation of adenosine base at nitrogen 6 position, is most common epitranscriptomic modification mRNA that affects a wide variety biological functions. We have previously reported hepatitis B viral RNAs are m6A-modified, displaying dual functional role in life cycle. Here, we show cellular m6A machinery regulates host innate immunity against and C infections by inducing transcripts. The depletion writer enzymes (METTL3 METTL14) leads to an increase RNA...
Interferon (IFN) stimulates a whole repertoire of cellular genes, collectively referred to as ISGs (Interferon-stimulated genes). ISG20, 3´-5´ exonuclease enzyme, has been previously shown bind and degrade hepatitis B Virus (HBV) transcripts. Here, we show that the N6-methyladenosine (m6A)-modified HBV transcripts are selectively recognized processed for degradation by ISG20. Moreover, this effect ISG20 is critically regulated m6A reader protein, YTHDF2 (YTH-domain family 2). Previously,...
Significance N6-methyladenosine (m 6 A) modification occurs in cellular RNAs and viral transcripts regulates the fate of RNAs. Hepatitis B virus (HBV) are m A-methylated consensus DRACH motif epsilon stem–loop, this differentially life cycle depending on A position at 5′- or 3′-epsilon stem–loop. Here, we report that HBV X (HBx) protein recruits machinery onto minichromosome host PTEN chromosomal locus to add cotranscriptionally. Induced mRNA by HBx decreases their stability. This study...
Hepatitis C virus (HCV) infections are associated with the risk of progression to fibrosis, cirrhosis, and hepatocellular carcinoma. The HCV RNA genome is translated by an internal ribosome entry site (IRES)-dependent mechanism. structure function IRES have been investigated both biological biophysical criteria. Recently, role N6-methyladenosine (m6A) in cellular viral transcripts has intensely investigated. m6A-methylated, this modification regulates life cycle. In study, we m6A...
YTHDC1 and fragile X mental retardation protein (FMRP) bind N6-methyladenosine (m6A)-modified RNAs facilitate their transport to the cytoplasm. Here, we investigated role of these proteins in hepatitis B virus (HBV) gene expression life cycle. We have previously reported that HBV transcripts are m6A methylated, this modification regulates viral is particularly interesting, as its DNA genome upon transcription gives rise a pregenomic RNA (pgRNA), which serves template for reverse produce...
Hepatitis B virus (HBV) contains a partially double-stranded DNA genome. During infection, its replication is mediated by reverse transcription (RT) of an RNA intermediate termed pregenomic (pgRNA) within core particles in the cytoplasm. An epsilon structural element located 5' end pgRNA primes RT activity. We have previously identified N6-methyladenosine (m6A)-modified DRACH motif at 1905 to 1909 nucleotides structure that affects myriad functions viral life cycle. In this study, we...
Pepper (Capsicum annuum) is an important vegetable crop that has been subjected to intensive breeding, resulting in limited genetic diversity, especially for sweet peppers. Previous studies have reported pepper draft genome assemblies using short read sequencing, but their capture of the extent large structural variants (SVs), such as presence-absence (PAVs), inversions, and copy-number (CNVs) complex falls short. In this study, we sequenced genomes representative hot accessions by long-read...
Abstract tRNA-derived RNA fragments (tRFs) have emerged as a new class of functional RNAs implicated in cancer, metabolic and neurological disorders, viral infection. Yet our understanding their biogenesis functions remains limited. In the present study, through analysis small profile we identified distinct set tRFs derived from pre-tRNA 3′ trailers hepatocellular carcinoma cell line Huh7. Among those tRFs, tRF_U3_1, which is 19-nucleotide-long chr10.tRNA2-Ser(TGA)-derived trailer, was...
Two new potent anti-Gram negative compounds, coralmycins A (1) and B (2), were isolated from cultures of the myxobacteria Corallococcus coralloides M23, together with another derivative (3) that was identified as very recently reported cystobactamid 919-2. Their structures including relative stereochemistry elucidated by interpretation spectroscopic, optical rotation, CD data. The 3 revised to "S*R*" NMR analysis. antibacterial activity 1 most against Gram-negative pathogens, Escherichia...
Abstract The recognition of pathogen-derived ligands by pattern receptors activates the innate immune response, but potential interaction quorum-sensing (QS) signaling molecules with host anti-viral defenses remains largely unknown. Here we show that Vibrio vulnificus QS molecule cyclo(Phe-Pro) (cFP) inhibits interferon (IFN)-β production interfering retinoic-acid-inducible gene-I (RIG-I) activation. Binding cFP to RIG-I 2CARD domain induces a conformational change in RIG-I, preventing...
Hepatitis C virus (HCV) infection is responsible for various chronic inflammatory liver diseases. Here, we have identified a naturally occurring compound with anti-HCV activity and elucidated its mode of antiviral action.
Capsaicinoids provide chili peppers (Capsicum spp.) with their characteristic pungency. Several structural and transcription factor genes are known to control capsaicinoid contents in pepper. However, many other also regulating remain unknown, making it difficult develop pepper cultivars different levels of capsaicinoids. Genomic selection (GS) uses genome-wide random markers (including undiscovered genes) for a trait improve efficiency. In this study, we predicted the breeding lines using...
Pepper (Capsicum spp.) holds significant value as both a vegetable and spice crop cultivated across the world, belonging to genus Capsicum of Solanaceae family. In addition its culinary applications, pepper finds extensive utility in pharmaceutical cosmetics sectors. Breeding plants with improved nutritional qualities will require comprehensive understanding biosynthetic pathway genes their regulatory functions. Advances molecular biology biotechnology have facilitated identification...
This study investigates the surface characteristics of printing papers using fractal geometry, focusing on roughness and friction as independent properties. The dimension (FD) was analyzed power spectral density method, which provided a more distinct characterization paper surfaces compared to variogram method. Surface were measured stylus-based contact profilometer, mean absolute deviation (MAD) parameters, such (RMAD) friction, calculated capture variability. results revealed that while...
Pepper (Capsicum spp.) fruit-related traits are critical determinants of quality. These controlled by quantitatively inherited genes for which marker-assisted selection (MAS) has proved insufficiently effective. Here, we evaluated the potential genomic selection, in genotype and phenotype data a training population used to predict phenotypes test with only data, predicting pepper. We measured four fruit (fruit length, width, weight, pericarp thickness) 350 accessions from pepper core...