A5005984358- Hepatitis C virus research
- Hepatitis B Virus Studies
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- HIV/AIDS drug development and treatment
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Hematopoietic Stem Cell Transplantation
- Tuberculosis Research and Epidemiology
- Acute Myeloid Leukemia Research
- Galectins and Cancer Biology
- Erythrocyte Function and Pathophysiology
- Toxin Mechanisms and Immunotoxins
- Platelet Disorders and Treatments
- Multiple Myeloma Research and Treatments
- Mitochondrial Function and Pathology
- Cancer-related Molecular Pathways
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Synthesis and biological activity
- Nuclear Structure and Function
- Cancer-related molecular mechanisms research
- High Altitude and Hypoxia
Dongguk University
2012-2024
Institut Pasteur Korea
2020
Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant genetic disease that caused by silent mutation of the LMNA gene encoding lamins A and C (lamin A/C). The G608G generates more accessible splicing donor site than does WT produces an alternatively spliced product called progerin, which also expressed in normal aged cells. In this study, we determined progerin binds directly to lamin A/C induces profound nuclear aberrations. Given observation, performed random screening...
Booster of pluripotency: RSC133, a new synthetic derivative indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming human somatic cells into pluripotent state aids growth maintenance stem (hPSCs). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
Hypoxia-inducible factor (HIF)-1α is a crucial transcription associated with cancer metabolism and regarded as potent anticancer therapeutic strategy within the hypoxic microenvironment of cancer. In this study, stilbenoid derivatives were designed, synthesized, assessed for their capacity to inhibit HIF-1α-associated evaluated inhibition cell viability HIF activation. Through structure-activity relationship studies, compound 28e was identified most derivative. Specifically, under condition,...
A series of (E)-phenoxyacrylic amide derivatives were synthesized and evaluated as hypoxia inducible factor (HIF) 1α inhibitors. The present structure–activity relationship study on this identified the morpholinoethyl containing ester 4p a potent inhibitor HIF-1α under hypoxic conditions (IC50 = 0.12 μM in cell-based HRE reporter assay) HCT116 cells. representative compound suppressed hypoxia-induced accumulation targeted gene expression dose-dependent manner. effect inhibition by was...
We report that phytosphingosine, a sphingolipid found in many organisms and implicated cellular signaling, promotes megakaryocytic differentiation of myeloid leukemia cells. Specifically, phytosphingosine induced several hallmark changes associated with megakaryopoiesis from K562 HEL cells including cell cycle arrest, size increase polyploidization. also confirmed type specific markers megakaryocytes, CD41a CD42b are by phytosphingosine. Phospholipids highly similar structures were unable to...
A series of indole acrylamide derivatives were synthesized and evaluated for their inhibitory effects on hepatitis C virus (HCV) replication. Previously, we have identified ( E )‐ N ‐(4‐ tert ‐butylphenyl)‐3‐(5‐cyano‐1 H ‐indol‐3‐yl)‐2‐methylacrylamide 6c ) as one the promising leads anti‐HCV chemotherapy. Based structural features acrylamide, explored extended structure–activity relationship study using analogs with substituted indoles, various amides, N‐substitution at ring. Among newly...
Previously, we discovered a series of indole derivatives as new class hepatitis C virus (HCV) replication inhibitors by using target-free chemical genetic strategy.Through structure-activity relationship study, the compound 12e was identified most potent inhibitor this (EC 50 = 1.1 μmol/l) with minimal cytotoxicity (CC 61.8μmol/l).In order to gain insight into its detailed antiviral mechanism action, performed PCR array analyses and found that able activate transcription number...
Pluripotenz-Booster: RSC133, ein neues synthetisches Derivat von Indolacrylsäure/Indolpropionsäure, zeigt zweifache Aktivität, indem es Histondeacetylase und DNA-Methyltransferase inhibiert. Außerdem verbessert wirksam die Reprogrammierung menschlichen somatischen Zellen in einen pluripotenten Zustand unterstützt Wachstum Erhaltung humanen Stammzellen (hPSCs).
We have previously reported the effects of 2-(trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a synthetic phospholipid, on megakaryocytic differentiation myeloid leukemia cells. Here, we demonstrate that (R)-TEMOSPho enhances megakaryopoiesis and plateletogenesis from primary hematopoietic stem cells (HSCs) induced by thrombopoietin (TPO). Specifically, at sub-saturation levels TPO, addition maturation megakaryocytes (MKs) murine HSCs derived fetal...