A5054125570- Lubricants and Their Additives
- Tribology and Wear Analysis
- Adhesion, Friction, and Surface Interactions
- Mechanical Behavior of Composites
- Bone Tissue Engineering Materials
- Metal and Thin Film Mechanics
- Cancer, Hypoxia, and Metabolism
- Dental Implant Techniques and Outcomes
- Astro and Planetary Science
- Extracellular vesicles in disease
- Spacecraft Dynamics and Control
- MicroRNA in disease regulation
- Advanced Sensor and Energy Harvesting Materials
- Pulsars and Gravitational Waves Research
- Geophysics and Gravity Measurements
- Stellar, planetary, and galactic studies
- Numerical methods in engineering
- Space Satellite Systems and Control
- Circular RNAs in diseases
- Periodontal Regeneration and Treatments
- Diamond and Carbon-based Materials Research
- Spacecraft Design and Technology
- Bioactive natural compounds
- Advanced materials and composites
- Elasticity and Material Modeling
Shenyang Agricultural University
2024-2025
Southwest Jiaotong University
2017-2024
Changhai Hospital
2012-2024
Second Military Medical University
2012-2024
Shenyang Institute of Engineering
2024
Chinese Academy of Sciences
2006-2023
Institute of Biophysics
2021-2023
Huazhong University of Science and Technology
2023
Changsha University of Science and Technology
2022
University of Chinese Academy of Sciences
2007-2022
Exosomes, as important players in intercellular communication due to their ability transfer certain molecules target cells, are believed take similar effects promoting bone regeneration with derived stem cells. Studies have suggested that umbilical cord mesenchymal cells (uMSCs) could promote angiogenesis. This study investigated whether exosomes from uMSCs (uMSC-Exos) enhance fracture healing primary factors by angiogenesis.uMSCs were obtained isolate uMSC-Exos ultrafiltration, human...
Repair of large bone defects represents a major challenge for orthopedic surgeons. The newly formed microvessels inside grafts play crucial role in successful tissue engineering. Previously, an active mesenchymal stem cell (MSC)-derived exosomes blood vessel development and progression was suggested the repair multiple tissues. However, reports on application MSC-derived are sparse. In this study, we encapsulated umbilical (uMSCEXOs) hyaluronic acid hydrogel (HA-Gel) combined them with...
Tracking the target: To identify a protein that binds directly to HIF-1α inhibitor LW6, series of new chemical probes were synthesized with clickable tag and/or photoactivatable moiety. LW6 was found be localized mitochondria (see picture) and MDH2 identified as target LW6. These results indicate inhibitory activity is consequence suppression. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may re-organized...
Tumour-associated macrophages (TAMs) are thought to contribute oral squamous cell carcinoma (OSCC) initiation and progression. However, the underlying mechanism through which TAMs foster OSCC progression is still unclear. This study intended determine whether there exclusively exosomal miRNAs-derived that functionally necessary for The phenotype of TAM recruitment in tissue samples was assessed, subsequently identifying influence M2 exosomes derived from on proliferation tumorigenesis vitro...
Abstract Background Plant cell walls have evolved precise plasticity in response to environmental stimuli. The plant heterotrimeric G protein complexes could sense and transmit extracellular signals intracellular signaling systems, activate a series of downstream responses. dep1 ( Dense Erect Panicles 1 ), the gain-of-function mutation DEP1 encoding γ subunit, confers rice multiple improved agronomic traits. However, effects on wall biosynthesis wall-related traits remain largely unknown....
Tissue engineering is a promising strategy for bone regeneration in repairing massive defects. The surface morphology of implanted materials plays key role healing; these incorporate osteoinductive factors to improve the efficiency regeneration.In current study, nanostructured hydroxyapatite (nHAp) micro-spheres were prepared via hydrothermal transformation method using calcium silicate (CS) microspheres as precursors; CS obtained by spray-drying method. nHAp constructed nano-whiskers...
Fabrication of membranes with excellent biocompatibility and bioactivity remains an important technical challenge in bone tissue engineering. In this paper, poly(l-lactic-co-glycolic acid) (PLGA)–SBA15 (Santa Barbara Amorphous 15) composite were prepared by using electrospinning technique; PLGA was used as a biocompatible biodegradable polymer SBA15 mesoporous silica. The PLGA–SBA15 membrane facilitates the cell attachment proliferation versus pure where human marrow-derived mesenchymal stem...
Abstract Long‐term service lifetime estimation of soft adhesives is critical for their reliability and durability but often expensive time‐consuming. The applicability the time–temperature superposition principle (TTSP) to predict shear fatigue life adhesive was investigated by systematic experiments. Through analysis energy dissipation mechanism, it found that viscoelastic stage played a dominant role in process lap configuration. master curve at reference temperature could be successfully...
Salt stress limits plant growth and agricultural productivity plants have evolved suitable mechanisms to adapt salinity environments. It is important characterize genes involved in salt tolerance, which will advance our understanding of mediating tolerance help researchers design ways improve crop performances under high Here, we reported a CYP450 family member, CYP75B4, improves rice seedlings by inducing flavonoid tricin cell wall lignin accumulation. The CYP75B4 highly expressed tissues...
Abstract Iron overload is a common stress in the development of cells. Growing evidence has indicated that iron associated with osteoporosis. Therefore, enhancing understanding would benefit novel approaches to treatment The purpose present study was analyze effect on osteoblast cells, via MC3T3‐E1 cell line, and explore its possible underlying molecular mechanisms. Ferric ammonium citrate (FAC) utilized simulate conditions vitro. FAC‐induced strongly suppressed proliferation cells induced...
Photosystem I (PSI) is a very large membrane protein complex (∼1000 kDa) harboring P700*, the strongest reductant known in biological systems, which responsible for driving NAD(P)+ and ultimately CO2 reduction. Although PSI one of most important components photosynthesis machinery, it has remained difficult to enhance functions through genetic engineering due its enormous complexity. Inspired by PSI's ability undergo multiple-step photo-induced electron hopping from P700* iron–sulfur [Fe4S4]...
The treatment of open tibial shaft fractures is challenging. External fixation (EF) comparatively safe in treating these injuries, meanwhile it has the advantages easy application, minimal additional disruption, and convenient subsequent soft tissue repair. Nevertheless, its application accompanied by a series problems alignment bone healing. Therefore, limited internal (LIF), such as cortical screws, been used based on external fixator for better therapeutic effect. aim this study to...
The first total synthesis of the naturally occurring benzofurans, moracins O and P was achieved using a Sonogashira cross coupling reaction followed by in situ cyclization, absolute configuration natural moracin established.
Abstract Medical implants are widely used in clinical practice, such as cardiovascular stenting, maxillofacial surgery, and orthopedics. However, most of the traditional implant operations open invasive, resulting massive dissection soft tissue interruption blood supply. The accurate navigation for is considered one effective ways to reduce damage, which urgently desired clinic. Herein, a biocompatible NIR‐II J‐aggregates labelled mesoporous imaging‐guided osteosynthesis with minimal...