A5068150111- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Orthopaedic implants and arthroplasty
- Optical measurement and interference techniques
- biodegradable polymer synthesis and properties
- Immune Response and Inflammation
- Elbow and Forearm Trauma Treatment
- Hip and Femur Fractures
- Sarcoma Diagnosis and Treatment
- Dental materials and restorations
- Periodontal Regeneration and Treatments
- Orthopedic Surgery and Rehabilitation
- Non-Invasive Vital Sign Monitoring
- Management of metastatic bone disease
- ECG Monitoring and Analysis
- Osteoarthritis Treatment and Mechanisms
- Bone fractures and treatments
- Circular RNAs in diseases
- Pelvic and Acetabular Injuries
- MicroRNA in disease regulation
- Hemostasis and retained surgical items
- Airway Management and Intubation Techniques
- Advanced Vision and Imaging
- Heart Rate Variability and Autonomic Control
- Knee injuries and reconstruction techniques
Changhai Hospital
2013-2023
Second Military Medical University
2013-2023
Zhengzhou University
2021
Fudan University
2016-2021
Luohe Medical College
2021
Qingdao University
2020
University of Hong Kong
2018
University of Hong Kong - Shenzhen Hospital
2018
Repair of large bone defects represents a major challenge for orthopedic surgeons. The newly formed microvessels inside grafts play crucial role in successful tissue engineering. Previously, an active mesenchymal stem cell (MSC)-derived exosomes blood vessel development and progression was suggested the repair multiple tissues. However, reports on application MSC-derived are sparse. In this study, we encapsulated umbilical (uMSCEXOs) hyaluronic acid hydrogel (HA-Gel) combined them with...
The regeneration of functional tissue in osseous defects is a formidable challenge orthopedic surgery. In the present study, novel biomimetic composite scaffold, here called nano-hydroxyapatite (HA)/poly-ε-caprolactone (PCL) was fabricated using selective laser sintering technique. macrostructure, morphology, and mechanical strength scaffolds were characterized. Scanning electronic microscopy (SEM) showed that nano-HA/PCL exhibited predesigned, well-ordered macropores interconnected...
Immune reactions are a key factor in determining the destiny of bone substitute materials after implantation. Macrophages, most vital immune response affecting implants, critical formation, as well biomaterial-mediated repair. Therefore, it is to design with osteoimmunomodulatory properties reduce host-to-material inflammatory responses by inducing macrophage polarization. Our previous study showed that calcium silicate (CS) bioceramics could significantly promote osteogenesis. Herein, we...
Tissue engineering is a promising strategy for bone regeneration in repairing massive defects. The surface morphology of implanted materials plays key role healing; these incorporate osteoinductive factors to improve the efficiency regeneration.In current study, nanostructured hydroxyapatite (nHAp) micro-spheres were prepared via hydrothermal transformation method using calcium silicate (CS) microspheres as precursors; CS obtained by spray-drying method. nHAp constructed nano-whiskers...
It is an important challenge for bone repair to effectively deliver growth factors and at the same time prevent cure inflammation without obvious pathogen resistance. We designed a kind of antibacterial peptide-mimetic alternating copolymers (PMACs) inhibit kill both Gram-positive Gram-negative bacteria. The minimum inhibition concentrations (MICs) PMACs against E. coli S. aureus are 8.0 μg/mL, which much lower than that peptides synthesized by other methods such as widely used ring-opening...
Fabrication of membranes with excellent biocompatibility and bioactivity remains an important technical challenge in bone tissue engineering. In this paper, poly(l-lactic-co-glycolic acid) (PLGA)–SBA15 (Santa Barbara Amorphous 15) composite were prepared by using electrospinning technique; PLGA was used as a biocompatible biodegradable polymer SBA15 mesoporous silica. The PLGA–SBA15 membrane facilitates the cell attachment proliferation versus pure where human marrow-derived mesenchymal stem...
Abstract Iron overload is a common stress in the development of cells. Growing evidence has indicated that iron associated with osteoporosis. Therefore, enhancing understanding would benefit novel approaches to treatment The purpose present study was analyze effect on osteoblast cells, via MC3T3‐E1 cell line, and explore its possible underlying molecular mechanisms. Ferric ammonium citrate (FAC) utilized simulate conditions vitro. FAC‐induced strongly suppressed proliferation cells induced...
In this study, we used human amniotic membrane (AM) to prepare a dermal scaffold with intact basement (BM) and good biostability for quick expansion transplantation of epidermal keratinocytes (EKs). Fresh AM was treated by repeated freeze-thaw cycles DNase digestion. This new method able cleanse the cell components effectively retain BM structure continuous distributions laminin, collagen IV, VI, VII. Subsequently, acellular (AAM) cross-linked 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide...
Abstract Implant therapy after osteosarcoma surgery is a major clinical challenge currently, especially the requirements for mechanical properties, degradability of implants, and their inhibition residual tumor cells. Biodegradable magnesium (Mg) alloy as medical bone implant material has full advantages huge potential development space. Wherein, Mg–lithium (Li) based alloy, an ultra-light good properties implants under certain conditions, both Mg Li have inhibitory effects on Therefore,...
Gluteal muscle contracture is a clinical syndrome that involves and distortion of the gluteal muscles fascia fibers due to multiple causes. Physical examination demonstrates characteristic gait hip adduction internal thigh rotation. This study introduces new minimally invasive method for surgical release contracture. Patients with were assigned 4 categories: type A, occurred mainly in iliotibial tract; B, Iliotibial tract gluteus maximus; C1, movement contraction band was palpable snapping...
Infection and its complications are one of the greatest threats to health orthopedic patients. Mesoporous bioglass (MBG) scaffolds characterized by well-ordered, three-dimensional, nanometer-sized mesoporous structures, which facilitate adhesion hydroxyapatite loading drugs. MBG has been widely used as a new-generation biomaterial in bone tissue engineering. However, is very brittle lacks antibacterial activity. This limits applications treatment defects, especially large defects complicated...
To summarize the techniques and clinical effectiveness in treating scaphoid nonunion with nickel-titanium (Ni-Ti) arched shape-memory alloy connector combination autologous iliac bone grafts.This study retrospectively analyzed 18 cases treated connectors grafts. Based on nonunion, 2 were classified as type II (fibrous union), 4 III (mild sclerotic 6 IV (moderate resorption sclerosis), 5 V (severe 1 case VI (pseudarthrosis formation). At first 4, 8 12 weeks after surgery, wrist...
Acute lung injury (ALI) is a common clinical syndrome with high mortality. The chemokine ligand 25 (CCL25) involved in inflammation, leukocyte trafficking and immunoregulation. However, the role mechanism of CCL25 ALI are not fully understood yet. aim this study was to explore relationship between acute CCL25. In study, we first examined expression sepsis patients found that serum levels were relatively compared healthy individuals. Based on this, designed vitro vivo experiments verify...
Fasudil is a derivative of 5-isoquinoline sulfonamide, which Rho kinase inhibitor, wide range pharmacological effects. has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis mouse tissues ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used determine changes in cisplatin-induced and fasudil-induced attenuation injury. Metabolomic profiling revealed significant differences metabolites between...
Background: Defects of articular cartilage represent a common condition that usually progresses to osteoarthritis with pain and dysfunction the joint. Current treatment strategies have yielded limited success in these patients. Stem cells are emerging as promising option for regeneration. We aim summarize developmental history stem regeneration analyse relevant trends hotspots. Methods: screened all literature on from Web Science during 2010-2020 analysed research this field by VOSviewer...