A5079981812- Covalent Organic Framework Applications
- RNA Interference and Gene Delivery
- Advanced Polymer Synthesis and Characterization
- Antimicrobial agents and applications
- Antimicrobial Peptides and Activities
- Polydiacetylene-based materials and applications
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Dendrimers and Hyperbranched Polymers
- Mesoporous Materials and Catalysis
- Nanomaterials for catalytic reactions
- Membrane Separation and Gas Transport
- Catalytic Processes in Materials Science
- Nanoparticle-Based Drug Delivery
- Photopolymerization techniques and applications
- Advanced biosensing and bioanalysis techniques
- Polymer Surface Interaction Studies
- Surfactants and Colloidal Systems
- Supramolecular Chemistry and Complexes
- Membrane Separation Technologies
- Nanopore and Nanochannel Transport Studies
- TiO2 Photocatalysis and Solar Cells
- Iron oxide chemistry and applications
- Electrospun Nanofibers in Biomedical Applications
- Nuclear Structure and Function
Tongji University
2011-2021
Shanghai Tenth People's Hospital
2018
The facile loading of sensitive and fragile biomacromolecules, such as glucose oxidase, hemoglobin, ribonucleic acid (RNA), via synthetic vehicles directly in pure aqueous media is an important technical challenge. Inspired by the nucleus pore complex that connects cell cytoplasm across nuclear envelope, here we describe development a kind polymeric envelope-like vesicle (NEV) to address this problem. NEV tailored form polymer (70 nm, similar complex) within membrane based on nanophase...
TiO2 nanoparticle has been considered as a safe sunscreen agent to reduce the skin cancer risk when exposed sunlight. However, recently it was found that particles accelerate photodamage of due their photocatalytic degradation activity. To effectively eradicate this unwanted effect, we present new strategy toward preparation organic/inorganic hybrid polymer/TiO2 nanoparticles with highly effective UV-screening property but eliminated We prepared polymer micelles corona–shell–core structure...
An ideal gene carrier requires an excellent gating system to efficiently load, protect, deliver, and release environmentally sensitive nucleic acids on demand. Presented in this communication is a polymersome with "boarding gate" "debarkation the membrane complete above important missions. This dually gated self-assembled from block copolymer, poly(ethylene oxide)-block-poly[N-isopropylacrylamide-stat-7-(2-methacryloyloxyethoxy)-4-methylcoumarin-stat-2-(diethylamino)ethyl methacrylate]...
Antimicrobial resistance is an increasingly problematic issue in the world and there a present urgent need to develop new antimicrobial therapies without drug resistance. Antibacterial polymers are less susceptible but they prone inducing serious side effects due high positive charge. Herein we report peptide-grafted hyperbranched polymer which can self-assemble into unusual nanosheets with highly effective intrinsically antibacterial activity weak charges (+ 6.1 mV). The was synthesized by...
It is an important challenge for bone repair to effectively deliver growth factors and at the same time prevent cure inflammation without obvious pathogen resistance. We designed a kind of antibacterial peptide-mimetic alternating copolymers (PMACs) inhibit kill both Gram-positive Gram-negative bacteria. The minimum inhibition concentrations (MICs) PMACs against E. coli S. aureus are 8.0 μg/mL, which much lower than that peptides synthesized by other methods such as widely used ring-opening...
Hierarchical self-assembly offers great possibilities to mimic biological systems with finely arranged complex structures. Herein, we demonstrate the preparation and formation mechanism of an unusual giant polymer vesicle a latticelike membrane (GVLM). This GVLM is formed by fusion-induced particle assembly (FIPA) small vesicles that are self-assembled from poly(ethylene oxide)-block-poly[(2-(tetrahydrofuranyloxy)ethyl methacrylate)-stat-(6-(3,3-diphenylnaphthopyranyloxy)hexyl methacrylate)]...
Yolk-shell composites with an Fe3O4/silica hybrid shell and a polymer core are prepared via facile one-pot self-template process. Thicknesses of the inorganic interior space well controlled by tuning ternary phase separations.
The apparent size increase of poly(N-isopropyl acrylamide) (PNIPAM)-based polymeric micelles upon heating was usually ascribed to their volume growth or aggregation in aqueous solution. Herein we designed a photo-cross-linkable PNIPAM-based copolymer and proposed another thermo-responsive behaviour - fusion, which is disclosed by transmission electron microscopy (TEM) after situ fixing morphologies at desired temperatures.
The efficient removal of trace carcinogenic organic pollutants, such as polycyclic aromatic hydrocarbons (PAHs) and ionic dyes, from water is an important technical challenge. We report a highly effective recyclable multifunctional azobenzene (AZ)-based silica-supported polymeric adsorbent which can simultaneously remove both PAHs anionic dyes to below parts per billion (ppb) level based on multiple interactions the hydrophobic effect, π-π stacking electrostatic interactions, thus providing...
High-genus multicompartment vesicles (HGMVs) are self-assembled from block copolymers containing fluorescent and photo-responsive azobenzene groups.
Polymer vesicles have shown great potentials in biomedical applications.Traditional polymer a homogeneous hydrophobic membrane, whereas one emerging vesicle has an inhomogeneous which is composed of incompatible components that can undergo micro-phase separation.Recently, scientists been focusing on the functionalization membranes, endows membrane with various functionalities.In this feature article, concept was defined based previous studies field.The structure and its design principles...
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