As a convenient, effective and economical kidney replacement therapy for end-stage renal disease (ESRD), peritoneal dialysis is available in approximately 11% of ESRD patients worldwide. However, long-term treatment causes fibrosis. In recent years, the application potential molecular hydrogen biomedicine has been well recognized. Molecular selectively scavenges cytotoxic reactive oxygen species (ROS) acts as an antioxidant. this experiment, high glucose-induced fibrosis mouse model was...

Background:Acute kidney injury is a common clinical comorbidity and early diagnosis crucial for improving prognosis, but there still no ideal biomarker diagnosis. Material Methods:miRNA microarray was used detecting miRNA in subjected to renal ischemia-reperfusion 12 h after reperfusion. Real-time PCR performed validate the results of microarray. miRNAs ischemia group were twice as high sham group. Kidney-enriched miR-10a, miR-192, miR-194 detected rat plasma screen potential biomarkers...

Abstract Background Peritoneal dialysis (PD) remains limited due to failure caused by peritoneal fibrosis. Tamoxifen (TAM), an inhibitor of estrogen receptor 1 (ESR1), has been reported treat fibrosis, but the underlying mechanism unknown. In this study, we sought explore whether tamoxifen played anti-fibrotic role affecting transcription factor ESR1. Methods ESR1 expression was detected in human peritoneum. Mice were daily intraperitoneally injected with 4.25% glucose PD dialysate...

Objective: This study aimed to identify factors significantly associated with the occurrence of osteoporosis in elderly and very patients. Methods: Elderly hospitalized patients who were older than 60 years old, from Rehabilitation Hospital December 2019 2020 selected. Barthel index (BI), nutritional assessment, causes bone mineral density (BMD) reductions analysed. Results: A total 94 (83.56 ± 8.37 old) enrolled. With increasing age, BMD lumbar spine, femoral neck, shaft decreased,...

Abnormalities in the levels of calcium, phosphorus, and parathyroid hormone (PTH) serum are typical for patients with chronic kidney disease (CKD). They used routinely to predict onset CKD-mineral bone disorder (MBD). However, CKD-MBD associated metabolic pathway imbalance is not well understood. The objective study was identify endogenous signatures intact PTH using mass spectrometry-based metabolomics. This a cross-sectional study. Ultra performance liquid chromatography-Quadrupole...

Fasudil is a derivative of 5-isoquinoline sulfonamide, which Rho kinase inhibitor, wide range pharmacological effects. has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis mouse tissues ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used determine changes in cisplatin-induced and fasudil-induced attenuation injury. Metabolomic profiling revealed significant differences metabolites between...

To explore the possible impact factors on daytime sleepiness among peritoneal patients from a single center in China. A cross-sectional study was conducted 98 prevalent dialysis (PD) using both Pittsburgh Sleep Quality Index (PSQI) questionnaire of sleep quality and Epworth Sleepiness Scale (ESS) excessive (EDS). Biochemical differences between non-daytime population were evaluated, following univariate multivariable analysis to find risk disturbance. The prevalence "poor quality" (PSQI > 5)...

Abstract Depression is a major cause of illness and disability. We applied untargeted metabolomics using mass spectrometry to identify metabolic signatures associated with depression in serum explored the antidepressant effects lilies Rhizoma Anemarrhenae on an experimental model chronic unpredictable mild stress (CUMS). Meanwhile based UHPLC‐Q‐TOF‐MS was used study change metabolites CUMS rat evaluate (alone combination). Partial least squares‐discriminant analysis identified 30 as decisive...

Abstract The World Health Organization characterized coronavirus disease (COVID‐19) as a pandemic on March 11, 2020. Peritoneal dialysis patients have weakened immune system that is associated with high morbidity of infection. Thus, COVID‐19 prevention measures and management for peritoneal are urgent critical. Based published research previous clinical practices similar outbreaks, we aimed to make recommendations manage undergoing dialysis.

Abstract Pulmonary arterial hypertension (PAH) is one kind of chronic and uncurable diseases that can cause heart failure. Immune microenvironment plays a significant role in PAH. The aim this study was to assess the immune cell infiltration pathogenesis Differentially expressed genes based on microarray data were enriched several immune‐related pathways. To evaluate infiltration, sets GEO database, we used both ssGSEA CIBERSORT algorithm. Additionally, single‐cell RNA sequencing (scRNA‐seq)...

To analyze the association between vitamin D and performance of activity daily living in elderly.A total 94 patients over age 65 were eligible to participate if they had undergone a bone mineral density test stable health condition. Subjects further divided into two groups according (ADL): score 40 as high ADL group below low group.According univariate analysis, mean hip T score, serum creatinine/cystatin C ratio (CCR), significantly different (P=0.024, 0.008, 0.010). Multivariate ORs showed...

Background: As one of the most common forms cancer, non-small cell lung carcinoma (NSCLC), is characterized by oxygen deprivation (hypoxia). The transcription factor hypoxia-inducible (HIF)-1α a major mediator which responds hypoxia and regulates many contributing factors. various modes regulation are frequently focus research studies. With reference to previous published research, we hypothesized that promotes growth angiogenesis NSCLC via Akt-PDK1-HIF1α-YKL-40 pathway, verified it....

Abstract Type 1 cardiorenal syndrome (CRS1) is characterized by acute cardiac disease (e.g., heart failure [AHF]), leading to kidney injury. Sirtuin (SIRT1), an NAD + ‐dependent deacylase, has been found be associated with CRS1. To confirm whether a correlation exists between SIRT1 variants and the risk of CRS1, association prevalence CRS1 single‐nucleotide polymorphisms (SNPs) within gene was investigated in AHF patients. A total 316 Chinese participants (158 patients 158 age‐ sex‐matched...

Anemia is an almost universal complication of chronic kidney disease (CKD), and nearly all patients with end-stage renal (ESRD) approximately 70% those earlier stages CKD receive treatment for anemia.

Excessive daytime sleepiness (EDS) is associated with quality of life and all-cause mortality in the end-stage renal disease population. This study aims to identify biomarkers reveal underlying mechanisms EDS peritoneal dialysis (PD) patients. A total 48 nondiabetic continuous ambulatory patients were assigned group non-EDS according Epworth Sleepiness Scale (ESS). Ultra-high-performance liquid chromatography coupled quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) was used...

Renal fibrosis, which is characterized as progressive extracellular matrix accumulation, a common feature of different stages chronic kidney disease, and the degree fibrosis strongly associated with renal function. In clinical practice, precise understanding space distribution extremely important for diagnosis prognosis disease. Rapid advances in terahertz (THz) technology have been made, this has broad application bio-detection, it can interact measure collective vibrations rotations...

Peritoneal dialysis (PD) is a safe and home-based treatment for end-stage renal disease (ESRD) patients. The direct thermal damage of abdominal organs very rare.We report peritoneal patient presented pain feculent effluent 3 weeks after he instilled hot solution. In spite emergency exploratory laparotomy active treatment, the died septic shock. Biopsy revealed necrosis perforation intestines.Delayed bowel by fluid rare. Standardized performance first importance