A5011037553- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Dermatologic Treatments and Research
- Tissue Engineering and Regenerative Medicine
- Pressure Ulcer Prevention and Management
- Electrospun Nanofibers in Biomedical Applications
- Diabetic Foot Ulcer Assessment and Management
- Surgical Sutures and Adhesives
- Silk-based biomaterials and applications
- Cardiac Arrest and Resuscitation
- Reconstructive Surgery and Microvascular Techniques
- Injury Epidemiology and Prevention
- Periodontal Regeneration and Treatments
- Laser Applications in Dentistry and Medicine
- Disaster Response and Management
- Extracellular vesicles in disease
- Planarian Biology and Electrostimulation
- Sympathectomy and Hyperhidrosis Treatments
- Angiogenesis and VEGF in Cancer
- Hydrogels: synthesis, properties, applications
- Surgical site infection prevention
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Second Military Medical University
2015-2024
Academy of Medical Sciences
2024
Academia Sinica
2024
Tongji University
2024
Changhai Hospital
2013-2023
State Council of the People's Republic of China
2020
Maastricht University
2008
National Natural Science Foundation of China
2008
Wounds represent a grave affliction that profoundly impacts human well-being.Establishing barriers, preventing infections, and providing conducive microenvironment constitute the crux of wound therapy.Hydrogel, polymer with an intricate three-dimensional lattice, serves as potent tool in erecting physical barriers nurturing environment to healing.This enables effective control over exudation, hemostasis, accelerated closure, diminished scar formation.As result, hydrogels have gained...
Abstract Background Diabetic wounds are one of the most common and serious complications diabetes mellitus, characterized by dysfunction wound-healing-related cells in quantity quality. Our previous studies revealed that human amniotic epithelial (hAECs) could promote diabetic wound healing paracrine action. Interestingly, numerous demonstrated exosomes derived from stem critical vehicles for cell therapy. However, whether hAECs (hAECs-Exos) mediate effects on remains unclear. This study...
Hydrogels have long been used for encapsulating stem cell-derived conditioned mediums to achieve skin regeneration after wounding. However, inappropriate mechanical strength, low adhesion and elasticity limit their clinical application. To address these challenges, we engineered a hyaluronic acid-based hydrogel grafted with methacrylic anhydride N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butanamide (NB) groups encapsulate lyophilized amnion-derived medium (AM-CM). This...
Abstract Second-degree burns are the most common type of burn in clinical practice and hard to manage. Their treatment requires not only a consideration different outcomes that may arise from dressing changes or surgical therapies themselves but also an evaluation factors such as site, patient age area. Meanwhile, special attention should be given fact there is no unified standard specification for diagnosis, classification, procedure, infection diagnosis grading second-degree wounds. This...
Diabetic wounds, characterized by prolonged inflammation and impaired vascularization, are a serious complication of diabetes. This study aimed to design gelatin methacrylate (GelMA) hydrogel for the sustained release netrin-1 evaluate its potential as scaffold promote diabetic wound healing. The results showed that was highly expressed during proliferation phases normal whereas it synchronously exhibited aberrantly low expression in wounds. Neutralization inhibited healing, topical...
Interleukin-33 (IL-33) is associated with multiple diseases, including asthma, rheumatoid arthritis, tissue injuries and infections. Although IL-33 has been indicated to be involved in Staphylococcus aureus (S. aureus) wound infection, little known about how regulated as a mechanism increase host defense against skin bacterial To explore the underlying intricate we first evaluated expression of from S. aureus-infected human patients. Compared normal controls, was abundantly increased We next...
Human amniotic epithelial cells (hAECs) are nontumorigenic, highly abundant, and low immunogenic possess multipotent differentiation ability, which make them become ideal alternative stem cell source for regenerative medicine. Previous studies have demonstrated the therapeutic potential of hAECs in many tissue repairs. However, effect on diabetic wound healing is still unknown. In this study, we injected intradermally around full-thickness excisional skin wounds db/db mice found that...
Objective: To accelerate wound healing through promoting vascularization by using reactive oxygen species (ROS)-responsive nanoparticles loaded with stromal cell-derived factor-1α (SDF-1α). Methods: The ROS-reactive nanomaterial poly-(1,4-phenyleneacetone dimethylene thioketal) was synthesized, and its physical chemical properties were characterized. ROS-responsive containing SDF-1α prepared a multiple emulsion solvent evaporation method. loading capacity, stability, activity of the...
In this study, we used human amniotic membrane (AM) to prepare a dermal scaffold with intact basement (BM) and good biostability for quick expansion transplantation of epidermal keratinocytes (EKs). Fresh AM was treated by repeated freeze-thaw cycles DNase digestion. This new method able cleanse the cell components effectively retain BM structure continuous distributions laminin, collagen IV, VI, VII. Subsequently, acellular (AAM) cross-linked 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide...
Less apoptosis and excessive growth of fibroblasts contribute to the progression hypertrophic scar formation. Cuprous oxide nanoparticles (CONPs) could have not only inhibited tumor by inducing inhibiting proliferation cells, but also promoted wound healing. The objective this study was further explore therapeutic effects CONPs on formation in vivo vitro.In vivo, a rabbit ear model established New Zealand albino rabbits. Six full-thickness circular wounds (10 mm diameter) were made each ear....
White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This study aimed to determine the protective effects human amnion-derived mesenchymal stem cells (hAMSCs) against WSI-induced in rats. hAMSCs were injected into rats via tail vein 4 h after WSI. At 1, 3, 7, 14, 28 days cell injection, labeled with PKH26 lung, heart, liver, kidney tissues observed by...
Background Diabetic foot ulcers (DFUs) are one of the most popular and severe complications diabetes. The persistent non-healing DFUs may eventually contribute to such as amputation, which presents patients with significant physical psychological challenges. Fibroblasts critical cells in wound healing perform essential roles all phases healing. In diabetic patients, disruption fibroblast function exacerbates wound. This study aimed summarize hotspots evaluate global research trends on...
Umbilical cord-derived mesenchymal stem cells (UC-MSC) are promising candidates for wound healing. However, the low amplification efficiency of MSC in vitro and their survival rates after transplantation have limited medical application. In this study, we fabricated a micronized amniotic membrane (mAM) as microcarrier to amplify used mAM (mAM-MSC) complexes repair burn wounds. Results showed that could live proliferate on 3D culture system, exhibiting higher cell activity than 2D culture....