A5101644978- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Drug Delivery Systems
- Hydrogels: synthesis, properties, applications
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Advancements in Transdermal Drug Delivery
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Drug Solubulity and Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Nanocluster Synthesis and Applications
- Molecular Sensors and Ion Detection
- Polymer Surface Interaction Studies
- Luminescence and Fluorescent Materials
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Phagocytosis and Immune Regulation
- Photoacoustic and Ultrasonic Imaging
- Heme Oxygenase-1 and Carbon Monoxide
State Key Laboratory of Genetic Engineering
2015-2024
Fudan University
2015-2024
Central South University
2019-2024
Yunnan University
2024
Yunnan Institute of Environmental Sciences
2024
Shihezi University
2023
Ningxia Medical University
2023
Yangpu Hospital of Tongji University
2022
Xiangya Hospital Central South University
2019-2021
PharmacoGenetics (China)
2019-2020
A novel AIE probe with ESIPT characteristics, myricetin, has been easily purified from vine tea for reversible, selective and sensitive targeting of O2˙- in turn-on mode. Its nanocrystals exhibit large Stokes shift, high photostability, excellent biocompatibility, low cytotoxicity endogenous detection imaging vitro vivo.
Cytosolic delivery of small interfering RNA (siRNA) remains challenging, and a profound understanding the cellular uptake intracellular processing siRNA systems could greatly improve development siRNA-based therapeutics. Here, we show that caveolae-mediated endocytosis (CvME) accounts for robust mannose-modified trimethyl chitosan-cysteine/tripolyphosphate nanoparticles (MTC/TPP NPs) to macrophages by circumventing lysosomes. We Golgi complex ER are key organelles required efficient in which...
Several novel functionalized graft copolymer nanoparticles consisting of chitosan (CS) and the monomer methyl methacrylate (MMA), N-dimethylaminoethyl hydrochloride (DMAEMC), N-trimethylaminoethyl chloride (TMAEMC), which show a higher solubility than in broader pH range, have been prepared by free radical polymerization. The were characterized terms particle size, zeta potential, TEM, FT-IR. These 150−280 nm size carried obvious positive surface charges. Protein-loaded prepared, their...
To improve the efficiency of insulin via oral administration, pH-sensitive carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles (CCGN) were prepared. CCGN characterized by 1H NMR, dynamic light scattering, zeta potential, and transmission electron microscopy, hypoglycemic effect loaded route was evaluated in normal diabetic rats. exhibited a homogeneous morphology spherical shape with core−shell structure. They aggregated simulated gastric fluid while separated intestinal...
The effectiveness of the commonly used therapy is low for treating triple-negative breast cancer (TNBC). Macrophages, accounting up to 50% TNBC tumor mass, are involved in innate and adaptive immunity, which can serve as an effective weapon against via combined immunotherapy. Here, we engineered mannose glycocholic acid-modified trimethyl chitosan (MTG) nanoparticles (NPs) encapsulating signal regulatory protein α (SIRPα) siRNA (siSIRPα, a macrophage checkpoint inhibitor) mucin 1 (MUC1) pDNA...