A5100766020- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Metabolism and Genetic Disorders
- Memory and Neural Mechanisms
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy Metal Exposure and Toxicity
- Lysosomal Storage Disorders Research
- Carbohydrate Chemistry and Synthesis
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Galectins and Cancer Biology
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Photoreceptor and optogenetics research
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Biochemical and Molecular Research
- Retinal Development and Disorders
- RNA regulation and disease
- Circular RNAs in diseases
Hefei Institutes of Physical Science
2019-2025
High Magnetic Field Laboratory
2019-2025
Chinese Academy of Sciences
2013-2025
University of Science and Technology of China
2017-2025
Nantong University
2025
Fudan University
2015-2024
State Key Laboratory of Medical Neurobiology
2015-2024
Affiliated Hospital of North Sichuan Medical College
2020-2024
Children's Hospital of Philadelphia
2015-2024
Zhongshan Hospital
2018-2024
Abstract The survival of a cell depends on its ability to meet energy requirements. We hypothesized that the mitochondrial reserve respiratory capacity (RRC) is critical component bioenergetics can be utilized during an increase in demand, thereby, enhancing viability. Our goal was identify elements regulate and contribute development RRC involvement survival. results show activation metabolic sensors, including pyruvate dehydrogenase AMP-dependent kinase, increases cardiac myocyte via...
Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams and output channels cerebral cortex
High-density, strand-specific cDNA sequencing (ssRNA–seq) was used to analyze the transcriptome of Salmonella enterica serovar Typhi (S. Typhi). By mapping sequence data entire S. genome, we analyzed in a manner and further defined transcribed regions encoded within prophages, pseudogenes, previously un-annotated, 3′- or 5′-untranslated (UTR). An additional 40 novel candidate non-coding RNAs were identified beyond those annotated. Proteomic analysis combined with confirm refine annotation...
Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates Tn antigen (GalNAcα1-Ser/Thr-R) form core 1 Galβ1–3GalNAcα1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis. Here we show ablation X-linked gene in mice causes embryonic lethality and expression. Loss associated with loss T-synthase but not other enzymes glycoprotein biosynthesis, demonstrating specific vivo T-synthase. We generated genetically mosaic...
Significance Autophagy maintains cellular homoeostasis by bulk or selective degradation of cytoplasmic components including organelles protein aggregates. Its role in axon regeneration remains speculative. Here, we found that boosting autophagy stabilized microtubules degrading a microtubule destabilizing protein, SCG10 (superior cervical ganglia 10), cultured CNS neurons and promoted growth. Furthermore, treatment with specific autophagy-inducing peptide, Tat-beclin1, attenuated retraction,...
Genetic variants at the solute carrier family 39 member 8 (SLC39A8) gene locus are associated with regulation of whole-blood manganese (Mn) and multiple physiological traits. SLC39A8 encodes ZIP8, a divalent metal ion transporter best known for zinc transport. Here, we hypothesized that ZIP8 regulates Mn homeostasis Mn-dependent enzymes to influence metabolism. We generated Slc39a8-inducible global-knockout (ZIP8-iKO) liver-specific-knockout (ZIP8-LSKO) mice observed markedly decreased...
The present study was conducted to test the hypothesis that low concentrations of coated ZnO, as a substitute for high concentration ZnO (2250 mg Zn/kg), could improve intestinal immunity function and regulate microbiota composition, thus alleviating incidence diarrhoea in weaned piglets. A total eighty-four cross-bred piglets, at an age 28 (SEM 1) d, were allocated randomly, on basis average initial body weight (7·72 0·65) kg), seven treatment groups follows: 250 Zn (ZnO)/kg group (low Zn;...
For animals to survive, they must reliably predict during foraging which substances are suitable for consumption. Despite extensive study, the neural circuit mechanisms underlying such adaptive behavior remain poorly understood. Here, using a tastant (sucrose/quinine)-reinforced “go/no-go” task in male and female mice, we examined anatomical functional connectivity of linking insular cortex (IC) central amygdala (CeA) role this establishment appropriate behavioral responses. Using anatomic...