A5103269620- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Virus-based gene therapy research
- Cancer Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Clinical Nutrition and Gastroenterology
- Neuroblastoma Research and Treatments
- Cannabis and Cannabinoid Research
- Early Childhood Education and Development
- Memory and Neural Mechanisms
- Regulation of Appetite and Obesity
- Neurogenesis and neuroplasticity mechanisms
- Organ and Tissue Transplantation Research
- Biological and pharmacological studies of plants
- Allergic Rhinitis and Sensitization
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Genetics and Neurodevelopmental Disorders
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Respiratory and Cough-Related Research
Air Force Medical University
2015-2025
Xijing Hospital
2017-2025
Peking University First Hospital
2024
Peking University
2024
Cold Spring Harbor Laboratory
2014-2021
When facing stress, most individuals are resilient whereas others prone to developing mood disorders. The brain mechanisms underlying such divergent behavioral responses remain unclear. Here we used the learned helplessness procedure in mice examine role of medial prefrontal cortex (mPFC), a region highly implicated both clinical and animal models depression, adaptive maladaptive stress. We found that uncontrollable inescapable stress induced state-dependent changes excitatory synapses onto...
Cognitive dysfunction represents a prominent symptom in numerous prevalent mental illnesses, with systemic inflammation induced by cytokines recognized as critical factor contributing to cognitive impairments. However, significant proportion of individuals exposed do not develop dysfunction; instead, they exhibit adaptive responses this adverse condition. This study aims investigate the neural activity patterns within hippocampus and potential mechanisms that mediate resilience, particularly...
Objective: This study aimed to explore whether saliva pepsin concentration (SPC) could be regarded as a risk factor for the occurrence and unfavorable control of asthma in children with allergic rhinitis.Methods: A prospective was conducted on group 20 consecutive newly diagnosed rhinitis (referred group).All these underwent fractional exhaled nitric oxide (FeNO) measurement, lung function tests, assessment using 7-item Childhood Asthma Control Test (C-ACT) score.Simultaneously, consisting...
<div>Abstract<p><b>Purpose:</b> Ad5.SSTR/TK.RGD is an infectivity-enhanced adenovirus expressing a therapeutic thymidine kinase suicide gene and somatostatin receptor (SSTR) that allows for noninvasive transfer imaging. The purpose of this study was to identify the maximum tolerated dose (MTD), toxicities, clinical efficacy, biologic effects in patients with recurrent gynecologic cancer.</p><p><b>Experimental Design:</b> Eligible were treated...
<div>Abstract<p><b>Purpose:</b> Ad5.SSTR/TK.RGD is an infectivity-enhanced adenovirus expressing a therapeutic thymidine kinase suicide gene and somatostatin receptor (SSTR) that allows for noninvasive transfer imaging. The purpose of this study was to identify the maximum tolerated dose (MTD), toxicities, clinical efficacy, biologic effects in patients with recurrent gynecologic cancer.</p><p><b>Experimental Design:</b> Eligible were treated...
Abstract Sex differences in pain sensitivity have contributed to the fact that medications for curing chronic are unsatisfactory. However, underlying mechanism remains be elucidated. Brain‐derived estrogen participates modulation of sex and related emotion. G protein‐coupled receptor 30 (GPR30), identified as a novel with different distribution than traditional receptors, has been proved play vital role regulating affected by estrogen. contribution its sexually dimorphic pain‐related...