A5028470655- Cardiac Arrhythmias and Treatments
- Cardiovascular Syncope and Autonomic Disorders
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Bioactive Compounds and Antitumor Agents
- Cancer Mechanisms and Therapy
- Clinical Nutrition and Gastroenterology
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Traditional Chinese Medicine Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Function and Risk Factors
- Ferroptosis and cancer prognosis
- Healthcare and Venom Research
- Adenosine and Purinergic Signaling
- Renal Transplantation Outcomes and Treatments
- Digestive system and related health
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Acupuncture Treatment Research Studies
- Calcium signaling and nucleotide metabolism
Daping Hospital
2025
Army Medical University
2025
Chongqing University
2025
Union Hospital
2025
Huazhong University of Science and Technology
2025
Changhai Hospital
2024
Second Military Medical University
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
Wuxi People's Hospital
2012-2023
Piperlongumine has anti-cancer activity in numerous cancer cell lines via various signaling pathways. But there been no study regarding the mechanisms of PL on lung yet. Thus, we evaluated effects and possible non-small (NSCLC) cells vivo vitro. Our findings showed that induced apoptotic death suppressed DNA binding NF-κB a concentration dependent manner (0-15 μM) NSCLC cells. Docking model pull down assay directly binds to site nuclear factor-κB (NF-κB) p50 subunit, surface plasmon...
Transforming growth factor-beta (TGF-β), a pluripotent cytokine expressed in the colon, has crucial but paradoxical role colorectal cancer (CRC). TGF-β is potent proliferation inhibitor of normal colon epithelial cells and acts as tumor suppressor. However, also promotes invasion metastasis during late-stage CRC, thereby acting an oncogene. Thus, understanding factors behind roles elucidating mechanisms by which TGF-β-induced inhibition impaired CRC are necessary. Here, we found that N-Myc...
// Jie Zheng 1 , Hye Lim Lee Young Wan Ham 2 Ho Sueb Song 3 Min Jong 4 Jin Tae Hong College of Pharmacy and Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, 361-763, South Korea Department Chemistry, Utah Valley Orem, UT 84508, USA Oriental Medicine, Kyungwon Sujeong-gu, Seongnam, Gyeonggii 461-701, Obstetrics Gynecology, Daejeon St. Mary's Hospital, The Catholic University Korea, Jung-gu, 301-723, Correspondence to: Hong, e-mail: jinthong@chungbuk.ac.kr Song,...
Abstract Acquired resistance to osimertinib (Osi) remains a major obstacle in the treatment of patients with EGFR‐mutant non‐small cell lung cancer (NSCLC). AXL elevation is known key mechanism Osi‐resistance, and therapeutic strategies remain scarce. Emerging evidence reveals that an increased intracellular glutathione (GSH) level induces Osi resistance. In this study, new identified by which GSH regulates expression via peroxidase 4 (GPX4) Osi‐resistant cells. A multifunctional covalent...
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy. Pyroptosis, an inflammatory programmed cell death process, holds substantial promise for tumor immunotherapy. In this study, we explored the use of pyroptosis overcome immunotherapy resistance CRC. Methods We used a pyroptosis-related gene panel construct efficacy evaluation model and validated its performance by...
Background Cervical lymph node metastasis is a major factor influencing recurrence after surgery for papillary thyroid cancer. Molecular markers that can predict the presence of and assess aggressiveness microcarcinoma (PTMC) remain poorly understood. The research question addressed whether specific genes, such as thrombospondin-4 (THBS4), could serve predictive biomarkers guiding surgical strategies, particularly in cases where current imaging modalities fail to detect LNM central region,...
Rationale: Signal transducer and activator of transcription-3 (STAT3) plays a pivotal role in cancer biology. Many small-molecule inhibitors that target STAT3 have been developed as potential anticancer drugs. While designing the SH2 domain remains leading focus for drug discovery, there has growing interest targeting DNA-binding (DBD) protein. Methods: We demonstrated antitumor activity novel, (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol (MMPP) directly binds to DBD STAT3,...
Signal transducer and activator of transcription 3 (STAT3) nuclear factor-κB (NF-κB) are two representative factors that play a critical role in inflammation-associated tumorigenesis through multi-level cooperation. Unlike other types tumors, breast carcinomas have shown significant dependency on the non-classical NF-κB pathway as well classical one. The α subunit inhibitor κB kinase (IKK) complex, IKKα, is involved both activation NF-κB. Although cross-talk between STAT3 has been suggested...
Nonoperative treatment of intussusception: historical perspective.D P Frush, J Y Zheng, V G McDermott and S Bisset, 3rdAudio Available | Share
Background: The incidence of silent cerebral embolisms (SCEs) has been documented after pulmonary vein isolation using different ablation technologies; however, it is unreported in patients undergoing with atrial fibrillation (AF) Robotic Magnetic Navigation (RMN). purpose this prospective study was to investigate the incidence, risk predictors and probable mechanisms SCEs AF potential impact RMN on SCE rates. Methods Results: We performed a 166 paroxysmal or persistent who underwent...
In the present study, we synthesized several non‐aldehyde analogues of (E)‐2,4‐bis(p‐hydroxyphenyl)‐2‐butenal which showed anti‐cancer effect. Interestingly, among 16 compounds, found that (E)‐2‐methoxy‐4‐(3‐(4‐methoxyphenyl)prop‐1‐en‐1‐yl)phenol (MMPP) most significant anti‐proliferative effect on PA‐1 and SK‐OV‐3 ovarian epithelial cancer cells. MMPP treatment (0‐15 µg/mL) induced apoptotic cell death, enhanced expression cleaved caspase‐3, caspase‐9 in a concentration dependent manner....
The purpose of this study was to prospectively evaluate the efficacy and safety remote magnetic navigation (RMN) in comparison with manual catheter (MCN) performing ventricular tachycardia ablation.An electronic search performed using PubMed (1948-2013) EMBASE (1974-2013) studies comparing RMN MCN which were published prior 31 December 2013. Outcomes interest as follows: acute success, recurrence rate, complications, total procedure fluoroscopic times. Standard mean difference (SMD) its 95 %...
// Jie Zheng 1,* , Mi Hee Park Dong Ju Son 1 Min Gi Choi Jeong Soon Kyung Tak Nam Hae Deun Kim Kevin Rodriguez 2 Benjamin Gann Young Wan Ham Sang Bae Han and Jin Tae Hong College of Pharmacy Medical Research Center, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, Republic Korea Department Chemistry, Utah Valley Orem, UT, USA * These authors have contributed equally to this work Correspondence to: Hong, email: Han, Keywords : colon cancer, apoptosis, STAT3, NF-κB, death...