A5018710980- Temporomandibular Joint Disorders
- Mechanisms of cancer metastasis
- Osteoarthritis Treatment and Mechanisms
- Blood properties and coagulation
- Growth Hormone and Insulin-like Growth Factors
- Periodontal Regeneration and Treatments
- TGF-β signaling in diseases
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Cell Adhesion Molecules Research
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Clinical practice guidelines implementation
- Lung Cancer Research Studies
- Digestive system and related health
- Cancer Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Chromatin Remodeling and Cancer
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
Air Force Medical University
1998-2023
Xijing Hospital
2013-2023
Suzhou Traditional Chinese Medicine Hospital
2023
Transforming growth factor-beta (TGF-β), a pluripotent cytokine expressed in the colon, has crucial but paradoxical role colorectal cancer (CRC). TGF-β is potent proliferation inhibitor of normal colon epithelial cells and acts as tumor suppressor. However, also promotes invasion metastasis during late-stage CRC, thereby acting an oncogene. Thus, understanding factors behind roles elucidating mechanisms by which TGF-β-induced inhibition impaired CRC are necessary. Here, we found that N-Myc...
Objective To investigate the pathological effects on temporomandibular joint cartilage of an experimentally created unilateral anterior crossbite prosthesis. Methods Six‐week‐old female Sprague–Dawley rats were divided into experimental and control groups further three subgroups for time points ( n = 9). In groups, was by bonding two metal tubes left maxillary mandibular incisors. 2, 4, or 8 weeks after operation, histomorphological changes expression PCNA , COL II aggrecan, MMP ‐3, ‐9, ‐13,...
Osteoarthritis (OA) of the temporomandibular joint (TMJ) is associated with dental biomechanics. A major change during OA progression ossification osteochondral interface. This study investigated formation, radiological detectability, and mechanical property interface at an early stage, pathogenesis significance which in clinical interest remains elusive for TMJ. Unilateral anterior crossbite (UAC) was performed on 6-wk-old rats as we previously reported. TMJs were harvested 4, 12, 20 wk....
In a previous study, we elucidated the specific microRNA (miRNA) profile of hepatic differentiation. this aimed to clarify instructive role six overexpressed miRNAs (miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p) during differentiation human umbilical cord lining-derived mesenchymal stem cells (hMSCs) test whether overexpression any these is sufficient induce hMSCs into hepatocyte-like cells. Before differentiation, were infected with lentivirus containing miRNA inhibitor...
针对《2020年宫颈癌临床实践指南》涉及的病理更新内容进行解读，内容包括基于人乳头状瘤病毒（human papillomavirus，HPV）病因学的宫颈腺癌组织学新分类，HPV相关性宫颈腺癌浸润方式分类（Silva分类），对复发、进展或转移性宫颈癌患者进行NTRK基因融合检测推荐以及对宫颈癌肿瘤分期的病理评估等，旨在帮助国内病理同行加深对该指南病理更新内容的认识和理解。.
A chondrocyte-to-osteoblast lineage continuum exists in the growth plate. Adipogenic differentiation of chondrocytes vivo should be investigated. Here, unilateral anterior crossbite (UAC), which can induce osteoarthritic lesions temporomandibular joint (TMJ), was applied to 6-wk-old C57BL/6 mice. Matrix loss TMJ cartilage obvious, as demonstrated by safranin O staining, and condylar elastic modulus values, detected using atomic force microscopy (AFM), were reduced, indicating softening that...
Efferocytosis suppresses antitumour immune responses by inducing the release and secretion of cytokines. Long non-coding ribonucleic acids (lncRNAs) have various functions in different forms programmed cell death regulation. This study aims to explore potential role efferocytosis-related lncRNAs as biomarkers pancreatic adenocarcinoma (PAAD).Transcriptome profiles, simple nucleotide variations clinical data patients with PAAD were extracted from The Cancer Genome Atlas (TCGA) database....
鼻窦未分化癌是一种在组织学及免疫组织化学染色证实缺乏腺性、鳞状或其他明显细胞谱系特征的恶性上皮性肿瘤。近年来，分化差的鼻窦癌相关分子发病机制引人关注，依据不同的遗传学特征将未分化癌进行重新命名，如中线癌（也称NUT癌）、SMARCB1（INI1）缺失性癌等。鼻窦SMARCA4缺失性癌是未分化癌的一种新认识的组织学类型，具有因SMARCA4基因突变导致其蛋白表达缺失的这一独特的遗传学特征，属于高度侵袭性肿瘤。本文报道1例鼻窦SMARCA4缺失性癌，结合组织学、免疫表型和分子检测结果，讨论其临床病理特征及鉴别诊断，以期加深对鼻窦SMARCA4缺失性癌的认识，避免误诊。.
Objective: To explore the application of multidisciplinary treatment (MDT) and comprehensive management model in diagnosis early-stage lung cancer, analyze its clinical value feasibility significance promotion. Methods: A retrospective study 470 patients Xijing Hospital who underwent surgery after MDT from January 8, 2018 to December 31, 2019. There were 172 males 298 females, aged 23 79 (54.46±11.08) years. Basic information as well postoperative pathology analyzed, which 441 cases...
滤泡样结构多见于卵巢幼年型粒层细胞瘤、高血钙型小细胞癌和Sertoli-Leydig细胞瘤，是诊断上述肿瘤的一项重要形态学线索，但是该结构还可见于其他类型的卵巢原发性和转移性肿瘤甚至瘤样病变中，可能会给诊断具有此类特殊结构的卵巢肿瘤带来困难。鉴于此，本文结合2020年第5版WHO女性生殖系统肿瘤分类和既往文献报道，对具有滤泡样结构的卵巢肿瘤进行系统的总结，旨在为国内病理同行诊断具有此类结构的卵巢肿瘤提供思路。.