A5023625601- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Tuberous Sclerosis Complex Research
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Histiocytic Disorders and Treatments
- Polyomavirus and related diseases
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Medical Imaging and Pathology Studies
- Facial Nerve Paralysis Treatment and Research
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Gut microbiota and health
- Neuroendocrine Tumor Research Advances
- Facial Rejuvenation and Surgery Techniques
- Neurogenesis and neuroplasticity mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Osteoarthritis Treatment and Mechanisms
- Tracheal and airway disorders
- Air Quality and Health Impacts
- CRISPR and Genetic Engineering
- Atmospheric aerosols and clouds
- Cancer-related molecular mechanisms research
Shandong First Medical University
2024-2025
Liaocheng People's Hospital
2015-2025
Shenzhen Children's Hospital
2020-2024
Sun Yat-sen University
2017-2022
The First Affiliated Hospital, Sun Yat-sen University
2017-2022
Changchun University of Science and Technology
2010-2022
Zero to Three
2022
Guangdong Provincial People's Hospital
2020-2022
Air Force Medical University
2019-2021
Liaocheng University
2018
Sea fog is a particular kind of atmospheric aerosol that often poses hidden risks to ship navigation, ocean exploration, human productivity, and life. In light the aforementioned issues, this research conducted thorough investigation polarization transmission properties in sea environment. We studied physical characteristics established polarized radiative transfer model based on RT3/PolRadtran (polarized transfer) environment theory Mie scattering. The effects wavelength, state,...
Polymicrobial pulmonary infections, common in immunocompromised patients, often manifest more severe symptoms than monomicrobial infections. Clinical diagnosis delays may lead to mortality, emphasizing the importance of fast and accurate for these patients. Metagenomic next-generation sequencing (mNGS), as an unbiased method capable detecting all microbes, is a valuable tool identify pathogens, particularly cases where infections are difficult using conventional methods. A 50-year-old male...
The aim of this study was to analyze the phenotypic spectrum, treatment, and prognosis 72 Chinese children with SCN2A variants.The variants were detected by next-generation sequencing. All patients followed up at a pediatric neurology clinic in our hospital or telephone.In variants, seizure onset age ranged from first day life 2 years 6 months. epilepsy phenotypes included febrile seizures (plus) (n = 2), benign (familial) infantile 9), familial neonatal-infantile 3), neonatal 1), West...
Severe retinal ischemia causes persistent visual impairments in eye diseases. Retinal pigment epithelium (RPE) cells are located near the choroidal capillaries, and easily affected by ischemic or hypoxia. Ginsenoside Rg-1 has shown significant neuroprotective effects. This study was performed to test cytoprotective effect of ginsenoside RPE against hypoxia cobalt chloride (CoCl2) assaults, understand underlying mechanisms. We found that pre-administration significantly inhibited CoCl2-...
Parkinson's disease (PD) is one of the most common neurodegenerative disorders aging, characterized by degeneration dopamine neurons (DA neurons) in substantial nigra, leading to advent both motor symptoms and non-motor symptoms. Current treatments include electrical stimulation affected brain areas replacement therapy. Even though categories are effective treating PD patients, progression cannot be stopped. The research advance into cell therapies provides exciting potential for treatment...
This study aimed to elucidate how miR-27a-3p modulates the Wnt/β-catenin signaling pathway promote colorectal cancer (CRC) progression. Our results showed that expression of was up-regulated in CRC and closely associated with histological differentiation, clinical stage, distant metastasis patients' survival. mimic suppressed apoptosis promoted proliferation, migration, invasion cells vitro vivo. Whereas inhibitor Furthermore, RXRα target gene CRC. negatively correlated tissues. The...
The aim of this study is to evaluate the diagnostic value genome sequencing in children with epilepsy, and provide sequencing-based insights into molecular genetic mechanisms epilepsy help establish accurate diagnoses, design appropriate treatments assist counselling. We performed on 320 Chinese interpreted single-nucleotide variants copy number all samples. complete pedigree clinical data probands were established followed up. phenotypes, treatments, prognoses genotypes patients analysed....
Anatomical knowledge of the zygomatic cutaneous ligament is crucial for rejuvenation anteromedial midface. However, there a lack satisfactory descriptions anatomy ligament, and exact range location are still controversial. The present study attempts to clarify provide vital information clinical operations.Facial dissection was performed on 36 cadaver hemifaces. investigated recorded relative Frankfort horizontal line several vertical reference lines. relationship with surrounding anatomical...
Approximately 75% of epilepsy cases emerge in childhood, and 10%–30% these pediatric are resistant to standard drug therapies; however, the underlying causes resistance remain poorly understood. Focal cortical dysplasia (FCD) is a primary contributor often associated with resistance. We performed single-nucleus RNA sequencing (snRNA-seq) patch-clamp recording fresh brain tissue samples that were obtained from FCD patients during surgery. Our study revealed significant transcriptomic changes...
High-dose methotrexate (HDMTX) chemotherapy is generally accepted as an effective method for the treatment and prevention of extramedullary leukemia in children. However, it unknown whether HDMTX kills intestinal bacteria on a large scale, thus causing dysbacteriosis, which may turn influence progress or prognosis leukemia. The aim this study was to examine changes flora children with acute lymphoblastic (ALL) treated chemotherapy. Bacterial DNA stool from 36 healthy ALL were tested at...
Tuberous sclerosis complex (TSC) is a multi-system genetic disorder. Most patients have germline mutations in TSC1 or TSC2 but, 10%–15% do not TSC1/TSC2 detected on routine clinical testing. We investigated the contribution of low-level mosaic unsolved sporadic and families with TSC. Thirty-one TSC negative testing eight suspected parental mosaicism were sequenced using deep panel sequencing followed by droplet digital polymerase chain reaction. Pathogenic variants found 22/31 (71%)...
// Xiaozhe Fu 1, 2, 4, * , Xianqin Hu 3, Ningqiu Li 2 Feifei Zheng Xingxing Dong Jing Duan Qiang Lin Jiagang Tu Lijuan Zhao Zhibin Huang 1 Jianguo Su 4 5 Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory Drug Development, Ministry Agriculture, Aquatic Animal Immune Technology, Guangdong Provinces, Guangzhou, Guangdong, 510380, China Department Medicine, Center Marine Biology, College Fisheries, Freshwater Aquaculture Collaborative Innovation Hubei...
Abstract Objective The temporomandibular joint (TMJ) displays a high remodelling capability in response to occlusion changes. purpose of the current study was investigate responses TMJ condyles growing mice installation unilateral anterior crossbite (UAC) prosthesis and replacement UAC prothesis with bilateral elevation (BAE) prosthesis. Materials Methods C57BL/6J were randomly assigned blank control experimental groups. In groups, created, while others, BAE created after creation or removal...
Tuberous sclerosis complex (TSC) is a rare disease with high risk of epilepsy and cognitive impairment in children. Ketogenic diet (KD) therapy has been consistently reported to be beneficial TSC patients. In this study, we aimed investigate the efficacy safety KD treatment drug-resistant children TSC.In multicenter 53 (33 males 20 females) or caused by were retrospectively recruited from 10 hospitals January 1, 2010, December 31, 2020. Intention-to-treat analysis was used evaluate seizure...
Objective: We aimed to explore the associated clinical phenotype and natural history of patients with SYNGAP1 gene variations during early childhood identify their genotype-phenotype correlations. Methods: This study used a cohort 13 epilepsy developmental disorder due mutations, namely, 7 from Shenzhen Children's Hospital between September 2014 January 2020 6 previously published studies. Their data were studied. Results: A total children variants (eight boys five girls) identified. The age...