A5103171722- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- Biomedical Ethics and Regulation
- CRISPR and Genetic Engineering
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Anesthesia and Neurotoxicity Research
- Nuclear Receptors and Signaling
- Axon Guidance and Neuronal Signaling
- Periodontal Regeneration and Treatments
- Retinal Development and Disorders
- Mitochondrial Function and Pathology
- Hemophilia Treatment and Research
- dental development and anomalies
- Muscle Physiology and Disorders
- Cancer-related Molecular Pathways
- Bone and Dental Protein Studies
- Autophagy in Disease and Therapy
- Toxoplasma gondii Research Studies
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
Liaocheng People's Hospital
2014-2024
Liaocheng University
2017-2024
Shandong University of Traditional Chinese Medicine
2019-2022
City University of Hong Kong, Shenzhen Research Institute
2021
Shandong University
2020-2021
Second Hospital of Shandong University
2017-2020
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020
Institute of Physiology and Basic Medicine
2020
Qingdao University
2018
Taishan Medical University
2013-2017
Bleomycin exhibits effective chemotherapeutic activity against multiple types of tumors, and also induces various side effects, such as pulmonary fibrosis neuronal defects, which limit the clinical application this drug. Macroautophagy/autophagy has been recently reported to be involved in functions bleomycin, yet mechanisms their crosstalk remain insufficiently understood. Here, we demonstrated that reactive oxygen species (ROS) produced during bleomycin activation hampered autophagy flux...
The aim of the present study was to isolate stem cells from human exfoliated deciduous teeth (SHEDs) and identify their phenotypes multi‑lineage differentiation potential. Three SHED cell strains were successfully isolated three different subjects using outgrowth method. Flow cytometric analysis indicated that SHEDs displayed high expression mesenchymal markers CD73 CD90 but low hematopoietic marker CD34. PCR illustrated expressed CD44, CD90, osteoblast Alpl, Runx2, CBFA1 collagen Ⅰ,...
Parkinson's disease (PD) is one of the most common neurodegenerative disorders aging, characterized by degeneration dopamine neurons (DA neurons) in substantial nigra, leading to advent both motor symptoms and non-motor symptoms. Current treatments include electrical stimulation affected brain areas replacement therapy. Even though categories are effective treating PD patients, progression cannot be stopped. The research advance into cell therapies provides exciting potential for treatment...
Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of cell procedures is an important task professional associations devoted therapy. The Chinese Branch the International Association Neurorestoratology (IANR) completed first set guidelines governing application neurorestoration in 2011. IANR and (CANR) collaborated propose current version "Clinical Therapy Guidelines Neurorestoration (IANR/CANR 2017)". council...
Human neural progenitor cells (hNPC) derived from the developing brain can be expanded in culture and subsequently differentiated into neurons glia. They provide an interesting source of tissue for both modeling development future cellular replacement therapies. It is becoming clear that hNPC are regionally temporally specified depending on which region they were isolated its developmental stage. We show here cortex (hNPC(CTX)) ventral midbrain (hNPC(VM)) have similar morphological...
Alzheimer’s disease (AD) is the most prevalent age-related neurodegenerative which mainly caused by aggregated protein plaques in degenerating neurons of brain. These are consisting amyloid β (Aβ) fibrils and neurofibrillary tangles (NFTs) phosphorylated tau protein. Even though transgenic murine models can recapitulate some AD phenotypes, they not human cell AD. Recent breakthrough somatic reprogramming made it available to use induced pluripotent stem cells (iPSCs) for patientspecific...
Research progress in animal models and stem cell therapy for Alzheimer's disease Fabin Han,1,2 Wei Wang1, Chao Chen1 1Centre Stem Cells Regenerative Medicine, 2Department of Neurology, Liaocheng People's Hospital/The Affiliated Hospital, Taishan Medical University, Shandong, Republic China Abstract: (AD) causes degeneration brain neurons leads to memory loss cognitive impairment. Since current therapeutic strategies cannot cure the disease, represents a powerful tool treatment AD. We first...
Abstract: Cell therapy has been shown to be a key clinical therapeutic option for central nervous system disease or damage, and >30 types of cells have identified through preclinical studies as having the capacity neurorestoration. To standardize procedures cell one strategies treating neurological disorders, first set guidelines governing application neurorestoration was completed in 2011 by Chinese Branch International Association Neurorestoratology. Given rapidly advancing state field,...
Abstract: Human umbilical cord blood-derived mononuclear cells (hUCB-MNCs) were reported to have neurorestorative capacity for neurological disorders such as stroke and traumatic brain injury. This study was performed explore if hUCB-MNC transplantation plays any therapeutic effects Parkinson's disease (PD) in a 6-OHDA-lesioned rat model of PD. hUCB-MNCs isolated from blood administered the striatum rats. The apomorphine-induced locomotive turning-overs measured evaluate improvement motor...
Induced pluripotent stem cells (iPSCs) have become the leading research object in clinical application of restorative medicine. They are easily generated from diverse cell sources and functionally indistinguishable embryonic without accompanying ethical issues. To date, use iPSC-derived neural their progeny treatment neurodegenerative injurious diseases has achieved good results, with great potential drug development. However, because some unique biological properties differences traditional...
In order to promote the clinical use of neural progenitor or precursor cells for treating neurological diseases and damage, we need standardize culture procedures these cells. The Chinese Association Neurorestoratology put forward standards training operators, standardized management materials equipment, isolation progenitor/precursor cells, in preservation, transport, related safe operation progenitors. These cultures quality control also include Good Manufacturing Practice environment,...
Objective Parkinson's disease (PD), which is one of the most common neurodegenerative disorders, characterized by loss dopamine (DA) neurons in substantia nigra midbrain. Experimental and clinical studies have shown that fetal neural stem cells (NSCs) therapeutic effects neurological disorders. The aim this study was to examine whether were differentiated from NSCs had a rat model PD. Methods isolated 14-week-old embryos induced differentiate into neurons, DA glial cells, these their...
Abstract: Receptor tyrosine kinases mediate the extracellular signals and transmit them into cytoplasm by activating intracellular proteins through phosphorylation. Both Ephs platelet-derived growth factor (PDGF) receptors (PDGFRs) have been implicated in neurogenesis, but functional interaction between these two pathways is poorly understood. Here, we demonstrated that EphA4 directly interacts with PDGFRβ mutually activates each other when expressed HEK293T cells. H9-derived neural stem...
// Fabin Han 1, 6, * , Chao Chen Wei Wang Hao Song 1 Sen Li Jing Duan Xianjie Lu Shichao Wu Nan Zhang Qingfa Yan Shuwei Liu 2 Chongluo Fu 3 Chengbiao 4 and Paul 5 Centre for Stem Cells Regenerative Medicine, The Institute Tissue Engineering & Liaocheng University/The People’s Hospital, Liaocheng, Shandong, China Department of Human Anatomy, Shandong University, Jinan, College Biological Science, Neurobiology, Xinxiang Medical College, Xinxiang, Henan, Neurosciences, University...
Neural stem and progenitor cells (NSPCs) are important pluripotent cells, which have potential applications for cell replacement therapy. Ephrin receptors (Ephs) angiogenic growth factor a major impact on the proliferation differentiation of NSPCs. Potential interactions between EphA4 vascular endothelial (VEGF) receptor (VEGFR) 2, their roles in NSPC vitro remain unknown. In present study, mouse embryonic NSPCs were treated with ephrin-A1 or VEGF165 alone as well combination treatment...