A5100391900- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Galectins and Cancer Biology
- Melanoma and MAPK Pathways
- Phagocytosis and Immune Regulation
- Marine Invertebrate Physiology and Ecology
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Nuclear Receptors and Signaling
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Breast Lesions and Carcinomas
- Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- interferon and immune responses
- Cancer therapeutics and mechanisms
- Hippo pathway signaling and YAP/TAZ
- Circular RNAs in diseases
University of Science and Technology of China
2016-2025
Chinese Academy of Sciences
2016-2025
Affiliated Hospital of Nantong University
2024
Nantong University
2021-2024
Second Affiliated Hospital of Dalian Medical University
2023
Dalian Medical University
2023
Chinese Medical Association
2021
High Magnetic Field Laboratory
2016-2020
Qingdao University
2020
Affiliated Hospital of Qingdao University
2020
With growing concerns of the safety nanotechnology, in vivo toxicity nanoparticles (NPs) at environmental relevant concentrations has drawn increasing attentions. We investigated possible molecular mechanisms titanium (Ti-NPs) induction predicted concentrations. In nematodes, small sizes (4 nm and 10 nm) TiO2-NPs induced more severe toxicities than large (60 90 on animals using lethality, growth, reproduction, locomotion behavior, intestinal autofluorescence, reactive oxygen species (ROS)...
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. For decades, unilateral 6‑hydroxydopamine (6‑OHDA) rat model has been employed to investigate pathogenesis and therapy PD. However, behavior associated pathological features long term have not previously described dynamically. In present study, was established by 6‑OHDA injection in striatum. The PD determined 2 weeks following surgery, according apomorphine (APO)‑induced rotations, cylinder, rotarod open field...
Gastric cancer (GC) is one of the most common cancers with high mortality globally. However, molecular mechanisms GC are unclear, and prognosis poor. Therefore, it important to explore underlying screen for novel prognostic markers treatment targets.The genetic clinical data patients in The Cancer Genome Atlas (TCGA) was analyzed by weighted gene co-expression network analysis (WGCNA). Modules significance preservation were distinguished, ontology pathway enrichment performed. Hub genes...
The diversity in microglial phenotypes and functions following traumatic brain injury (TBI) is poorly characterized. aim of this study was to explore precise targets for improving the prognosis TBI patients from a perspective.
KIF20A is well known as one of the key proteins in mitosis. Recently, a number studies illustrated that might function an oncogene some carcinomas. However, its expression levels and clinical value remained unclear gastric cancer (GC).In this study, we investigated samples from GC patients cell lines by quantitative real-time PCR Western blot. The proliferation was examined via viability colony formation assays. Immunohistochemistry assay based on tissue microarray consisting 146 cases...
The metagenesis of sessile polyps into pelagic medusae in cnidarians represents one the most ancient complex life cycles animals. Interestingly, scyphozoans and hydrozoans generate by apparently fundamentally different processes. It is therefore unclear whether medusa formation has evolved independently medusozoans. To this end, a thorough understanding correspondence polyp required.
Cell adhesion is regulated by molecularly defined protein interactions and mechanical forces, which can activate a dynamic restructuring of sites. Previous attempts to explore the response cell forces have been limited applying stimuli that involve cytoskeleton. In contrast, we here apply new, oscillatory type stimulus through push-pull azobenzenes. Push-pull azobenzenes perform high-frequency, molecular oscillation upon irradiation with visible light has frequently applied in polymer...
TRIM62 (tripartite motif containing 62) has been found to act as a tumor suppressor of several cancers. However, its precise biological role and related mechanism remain unknown in cervical cancer (CC).Quantitative Real-time PCR western blot were adopted detect the mRNA protein expression level both human CC cell lines tissues. Immunohistochemistry was used measure 30 normal 189 Univariate multivariate Cox regression analyses Kaplan-Meier survival performed investigate association between...
Huaier, as known Trametes robiniophila Murr, is a traditional Chinese medicine. Various studies have demonstrated that Huaier could inhibit cancer progression and improve the prognosis of patients. In present study, we comprehensively screened expression profiles lncRNAs, miRNAs, mRNAs in Huaier-treated breast cells. Using bioinformatic analysis, hub genes were identified functionally annotated. Weighted gene coexpression network analysis was applied to construct molecular influenced by...
Abstract Human astroviruses (HAstVs) have been recognized as one of the major causes acute gastroenteritis in children. To provide more insight into prevalence HAstV China, 664 fecal samples were collected from children affected with Beijing March 2005 to November 2007. The analyzed genetically. All eight serotypes (genotypes) HAstVs screened using RT‐PCR assays targeting ORF2 region study. detected 52 (7.8%) patients, HAstV‐1 (50/52) being dominant genotype during study period. Two minor...
Abstract Electron paramagnetic resonance (EPR)-based hybrid experimental and computational approaches were applied to determine the structure of a full-length E. coli integral membrane sulfurtransferase, dimeric YgaP its structural dynamic changes upon ligand binding. The solution NMR structures transmembrane domain (TMD) cytosolic catalytic rhodanese reported recently, but tertiary fold was not yet available. Here, systematic site-specific EPR analysis defined helix-loop-helix secondary...
Small cell lung cancer (SCLC) is a highly malignant with few targeted therapies. In the study, by mining Cancer Cell Line Encyclopedia (CCLE) database, we found that PI3K/AKT/mTOR pathway was aberrant in 92% of SCLC lines. Moreover, phosphorylation level 4E-BP1 significantly correlated sensitivity to RAD001 (mTOR inhibitor) and BEZ235 (PI3K/mTOR dual inhibitor). Combination synergistically inhibited growth cells, which accompanied enhanced induction cycle arrest apoptosis. Such combination...
Large-scale pre-training models have promoted the development of histopathology image analysis. However, existing self-supervised methods for images primarily focus on learning patch features, while there is a notable gap in availability specifically designed WSI-level feature learning. In this paper, we propose novel framework pan-cancer representation with position-aware masked autoencoder (PAMA). Meanwhile, cross-attention (PACA) module kernel reorientation (KRO) strategy and an anchor...
BACKGROUND Lung cancer is the leading cause of deaths in world. Its major histopathological subtype non-small cell lung (NSCLC). Xiaoai Jiedu recipe (XJR) a traditional Chinese medicine formula that can suppress growth and invasion tumor cells. Here, we assessed antitumor effect XJR on NSCLC explored underlying mechanisms. MATERIAL AND METHODS Three concentrations (low, middle, high) were used to treat A549 Cell Counting Kit-8 colony formation assay measure proliferation Apoptosis was...
The mutation status and prognostic value of PIK3CA in breast cancer were widely investigated, which showed significant difference among the patients from vast areas around world. In this study, frequency, distribution, bias, burden mutations their relationships with clinicopathologic variables significances investigated Central China.Somatic exon 9 20 gene analyzed using Sanger sequencing combining targeted next generation 494 China. correlations between clinicopathological characteristics...
Objective: Recent studies suggest that not only is constipation a clinical marker of premotor phase in Parkinson’s Disease (PD), but also correlated with the duration and severity. Some reports indicated inflammatory from gut dysbiosis might be involved pathogenesis PD, correlation between them remains poorly understood. This study aims to investigate how presence affects dopamine level nigrostriatal system whether gastrointestinal (GI) inflammation brain-gut axis. Methods: Clinical...
Multiple instance learning (MIL) based whole slide image (WSI) classification is often carried out on the representations of patches extracted from WSI with a pre-trained patch encoder. The performance relies both patch-level representation and MIL classifier training. Most methods utilize frozen model ImageNet or trained self-supervised histopathology dataset to extract then fix these in training classifiers for efficiency consideration. However, invariance cannot meet diversity requirement...