A5101491769- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Synthesis of Organic Compounds
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Hepatitis B Virus Studies
- Neurological Disease Mechanisms and Treatments
- Esophageal Cancer Research and Treatment
- Fluorine in Organic Chemistry
- Intracranial Aneurysms: Treatment and Complications
- Sleep and related disorders
- Circadian rhythm and melatonin
- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Ferroptosis and cancer prognosis
- Cystic Fibrosis Research Advances
- Catalytic Cross-Coupling Reactions
- Cardiovascular Health and Risk Factors
- Iterative Learning Control Systems
XinHua Hospital
2023-2024
Shanghai Jiao Tong University
2020-2024
Harbin Medical University
2024
First Affiliated Hospital of Henan University
2019-2024
Second Affiliated Hospital of Harbin Medical University
2024
Capital Medical University
2010-2023
Beijing Jishuitan Hospital
2023
Peking University
2023
Xidian University
2023
Beijing Tian Tan Hospital
2018-2022
Introduction Intervertebral disc degeneration (IVDD) is an important contributor of low back pain, which represents one the most disabling symptoms within adult population. Recently, increasing evidence suggests potential association between Type 2 diabetes mellitus (T2DM) and IVDD. However, causal relationship these two common diseases remains unclear. Methods We conducted a two-sample Mendelian randomization (MR) analysis to assess T2DM Sensitivity was performed test for heterogeneity...
The diversity in microglial phenotypes and functions following traumatic brain injury (TBI) is poorly characterized. aim of this study was to explore precise targets for improving the prognosis TBI patients from a perspective.
Gallbladder cancer (GBC) is a highly malignant and rapidly progressing tumor of the human biliary system, there an urgent need to develop new therapeutic targets modalities. Non-POU domain-containing octamer-binding protein (NONO) RNA-binding involved in regulation transcription, mRNA splicing, DNA repair. NONO expression elevated multiple tumors can act as oncogene promote progression. Here, we found that was expressed GBC promoted cells growth. The dysregulation RNA splicing molecular...
Abstract Background Donkey meat has low fat and high protein contents is rich in various unsaturated fatty acids trace elements that are beneficial to human digestion absorption. IMF (intramuscular fat), also known as marbling, an important indicator of the lean ratio, which directly affects tenderness juiciness meat. At present, underlying molecular variations affecting content among donkey breeds unclear. The Guangling indigenous species China. This study explored candidate regulatory...
Insomnia is a disease where individuals cannot maintain steady and stable sleep state or fail to fall asleep. Western medicine mainly uses sedatives hypnotic drugs treat insomnia, long-term use prone drug resistance other adverse reactions. Acupuncture has good curative effect unique advantages in the treatment of insomnia.To explore molecular mechanism acupuncture at Back-Shu point for insomnia.We first prepared rat model then carried out 7 consecutive days. After treatment, time general...
Diosmin is a flavone glycoside with confirmed therapeutic effectiveness on the chronic venous disorders. In this paper, classical mouse depression model induced by LPS was established to explore effect of depression. Firstly, we found that could inhibit inflammation and neuronal damage in prefrontal cortex (PFC) mice, thus alleviating LPS-induced depressive-like behaviors. Specifically, treatment significantly suppressed secretion pro-inflammatory cytokines (TNF-α, IL-6 IL-1β), reduced...
Abstract Background Globally, rates of ischemic stroke (IS) have been rising among young adults. This study was designed to identify risk factors associated with IS incidence in adults unaffected by hypertension or diabetes. Methods a retrospective case-control early-onset patients without diabetes and hypertension. Control were matched healthy individuals based upon sex, age (±2 years), BMI (±3 kg/m 2 ) at 1:3 ratio. Sociodemographic, clinical, factor-related data pertaining these...
To investigate the causal relationship between intestinal flora and benign biliary diseases by genome-wide Mendelian randomization.
To analyze plaque characteristics of non-culprit coronary lesions with cholesterol crystals in patients acute myocardial infarction(AMI) by using optical coherence tomography(OCT). We also investigated the potential association between rupture and healed at segment.
Background: An imbalance of innate and acquired immune responses is significantly involved in the pathophysiology coronary atherosclerosis occurrence ischemic heart disease (IHD). Regulatory T cells (Tregs) play an essential regulatory role atherosclerotic plaque formation maintenance; therefore, dysfunction Tregs triggers plaques accelerates their progression. However, due to inherent limitations observational research, clinical evidence limited concerning relationship between variation...
Abstract Background: Insomnia is one of the most common diseases in modern society, main characteristics patients were difficulty falling asleep at night and/or failure to maintain effective sleep after asleep. It can lead early awakening, short sleep, heavy sleeplessness, dreaming, poor quality, and working hours waking up, causes a series negative emotions, such as fatigue, inefficiency, cognitive decline, social interaction, tension, anxiety, which affect harmony stability. So has gained...
Energy metabolic processes play important roles for tumor malignancy, indicating that related protein-coding genes and regulatory upstream (such as long noncoding RNAs (lncRNAs)) may represent potential biomarkers prognostic prediction. This study will develop a new energy metabolism-related lncRNA-mRNA signature lower-grade glioma (LGG) patients. A GSE4290 dataset obtained from Gene Expression Omnibus was used screening the differentially expressed (DEGs) lncRNAs (DELs). The Cancer Genome...
Abstract In the presence of 1,8-diazabicycolo[5.4.0]undec-7-ene (DBU) and concentrated H2SO4, 2-naphthol reacted smoothly with α,β-unsaturated trifluoromethyl ketones in CH2Cl2 at room temperature, affording 3-trifluoromethyl-substituted benzo[f]chromene derivatives good to excellent yields a one-pot reaction. [Supplementary materials are available for this article. Go publisher's online edition Synthetic Communications® following free supplemental resource: Full experimental spectral details].
To analyze the clinical and laboratory characteristics, prognosis of adult acute myeloid leukemia (AML) patients with MLL gene rearrangements.
Abstract The reactions of trifluoro or bromodifluoro acetamides with aromatic aldehydes in the presence thionyl chloride and trifluoromethylsulfonic acid were investigated. Compared procedure reported previously, yields improved greatly reaction conditions much milder. Both intra‐ intermolecular weak interactions discussed detail based on X‐ray diffraction analysis 3aa 3ab .